I-Ranexa (i-ranolazine) iyisidakamizwa esisha, esinezindlela eziyingqayizivele zesenzo, esetshenziselwa ukwelashwa kwe- angina . U-Ranexa uboniswe ngokuthuthukisa kakhulu isibalo sesikhathi iziguli ezine-angina ezizinzile zikwazi ukuzivocavoca ngaphambi kokuthuthukisa izimpawu futhi zamukelwa yi-FDA ngo-2008 njenge-ejenti yokuqala ye-angina.
Ekuqaleni kwakucatshangwa ukuthi uRanexa wenza ukuba imisipha yenhliziyo isuke ekusebenziseni amafutha e-acids ku-glucose ukukhiqizwa kwamandla, okwakunganciphisa inani le-oksijeni isidumbu senhliziyo esidingekayo ukusebenza.
Nokho, maduzane, ubufakazi obonakalayo obonisa ukuthi umphumela oyinhloko kaRanexa ukuvimbela empeleni lokho okubizwa ngokuthi "isiteshi se-sodium sekwephuzile" ezinomzimba we- ischemia , noma ukungabi khona kwe-oksijeni ehlobene ne- atherosclerosis , emithanjeni ye-coronary . Ukuvimba lesi siteshi se-sodium kuthuthukisa imetabolism amangqamuzana ehliziyo ischemic, ukunciphisa umonakalo emzimbeni wenhliziyo, futhi nokunciphisa izimpawu ze-angina.
Yini Angina?
U-Angina ubuhlungu noma abuhlungu esifubeni esibangelwa isisu senhliziyo esenqatshelwe igazi elicebile oksijini. Abanye bachaza umuzwa njengengcindezi noma ukucindezela, futhi ukungakhululeki kungabonakala emahlombe, izingalo, intamo, umhlathi noma emuva emuva kwesifuba. Ubuhlungu buka-Angina bungase buzwe sengathi buhlanjululwa.
U-Angina uyisigqila kunesifo futhi. Ngokujwayelekile, likhombisa isifo se-coronary (CHD) ngenxa yokunciphisa eyodwa noma ngaphezulu kwemithambo ye-coronary, eyaziwa ngokuthi i-ischemia.
I-Ranexa isetshenziselwa ukwelapha angina okungapheli, kodwa kunezinye izinhlobo eziningi ze-angina, kuhlanganise nama-angina ezincane, ama-angina aphelile, ama-angina azinzile, ama-angina angaguquki futhi ama-angina ahlukile.
Imiphumela ye Side Ranexa
Imiphumela emibi kakhulu ebikwe uRanexa yilezi zikhanda, ukuqothulwa, kanye nesicashu.
Okunye eminye imiphumela emibi kakhulu ingafaka:
- isiyezi noma inzwa yokuphenya
- ikhanda
- umlomo owomile
- ubuthakathaka
- ukukhala ezindlebeni
Ngaphezu kwalokho, ngenkathi uthatha u-Ranexa, kubalulekile ukulalela noma yikuphi kwalokhu okulandelayo imiphumela emibi futhi ufune isiqondiso esivela kudokotela wakho uma kwenzeka:
- uzizwa sengathi ungadlula
- ukuvuvukala ezandleni, ezinqoleni noma ezinyaweni
- ukuphuza, ukushesha, noma ukushaya izinhliziyo
- ukuthuthumela
- igazi emcinini
- ukuvuthwa kaningi kangako noma cha nhlobo
- ukuphelelwa umoya
- ukuvuthwa, ukulimaza, ukugubha, ukuphazamiseka, ubuhlungu, noma ubunzima bezinsipho
Ekuqaleni, ukukhathazeka okuyinhloko ngoRanexa kwakuwukuthi kungenza isikhathi eside se "QT interval" ku-ECG (isilinganiso somsebenzi kagesi ngaphakathi kwenhliziyo). Ezinye izidakamizwa ezinomphumela zingandisa ingozi yokuthuthukisa izifo zenhliziyo eziyingozi . Kodwa-ke, ukuhlolwa okucophelile kubonise ukuthi le ngozi ingabi ncane noma ayitholakali noRanexa. Eqinisweni, uRanexa manje uboniswe empeleni ukunciphisa ingozi yokuthuthukisa ama-arthritis and fibrillation .
Ngaphezu kwalokho, abantu abane-cirrhosis (scarring) yesibindi akufanele bathathe uRanexa, futhi futhi akufanele futhi abantu bathathe i-wort St. John kanye neminye imithi ye:
- ukukhulelwa kwezifungus
- ukutheleleka
- ukucindezeleka
- I-HIV
- Isifo sofuba (i-TB)
- ukuhlukunyezwa
Imithombo:
Chaitman, BR. I-Ranolazine yokwelapha i-angina engapheli kanye nokusetshenziswa okungenzeka kwezinye izimo zenhliziyo. Ukujikeleza kuka-2006; 113: 2462.
UMorrow DA, uScirica BM, Karwatowska-Prokopczuk E, et al. Imiphumela ye-ranolazine ezigamekweni ezivame ukushaya inhliziyo ezigulini ezinezinkinga ezingezona eze-ST-elevation acon coronary syndromes. I-MERLIN-TIMI isivivinyo sama-rand. I-JAMA 2007; 297: 1775-1783.
UBelardinelli L, Shryock JC, uFraser H. Indlela yokwenza i-ranolazine isenzo sokunciphisa ukukhubazeka kwesifo se-diastolic. I-Eur Heart J Suppl (Febhuwari 2006) 8 (isibalo A): A10-A13. doi: 10.1093 / eurheartj / sui091.