Imizimba yethu inama-hormone elawula zonke izici zesimetabolism, futhi lokhu kuhlanganisa nokudla nesisindo somzimba. Kuye kwatholakala ama-hormone amaningi athinta ukudla nokuthuthukiswa noma ukuvimbela ukukhuluphala . Kukhona ama-hormone amane amakhulu kakhulu: i- ghrelin , i-leptin, i-insulini, ne-peptide YY (i-PYY). Lesi sihloko sigxile ku-leptin.
Kuyini i-Leptin?
Ngokusho nje, i-leptin iyi-hormone esusa ukudla.
Kuye kwabizwa ngokuthi "isici satiety" ngalesi sizathu. Leptin ikhiqizwa ama-adipose (fat) amaseli. Ngakho izinga lokukhiqizwa kwalo lilingana namafutha omzimba. Lapho amazinga omzimba ekhuphuka, ngakho-ke amazinga we-leptin, asebenza ngakho ekunciphiseni ukudla futhi akhulise izinga eliyisisekelo semethamo. Uma amafutha omzimba ewela, kanjalo namazinga we-leptin, nokunciphisa ukudla kukhishwa, ukufakazela emzimbeni ukuthi sekuyisikhathi sokudla futhi. Ekuqaleni, lokhu kwasebenza ngenhloso yokuvimbela indlala.
I-Leptin ngezinye izikhathi ibhekwa njengomlingani we-ghrelin ngoba i- ghrelin (enye i-hormone elawula ukudla, eyenziwa yisisu kanye ne-duodenum) ivuselela inxanxathela njengoba amazinga ayo ephakama. Ngenxa yokuthi i-leptin inganciphisa ukudla ukudla ngokunciphisa ukudla, ingenza ukulahlekelwa isisindo; ukuphikisana nalokhu, ngoba i-ghrelin ingandisa ukondla kokudla ngokuvuselela ukudla, ingabangela ukuzuza kwesisindo nokukhuluphala.
Ngo-1994, igciwane elikhiqiza i-leptin, eyaziwa ngokuthi i-obes ( ob ) yesigameko somuntu, litholwe nguZhang kanye nozakwethu emagundwini.
I-Leptin ibike ukuthi inezinhlelo eziningi zezinto eziphilayo, kuhlanganise nezimpendulo zokuzivikela zomzimba nezokuvuvukala, indima ekusungulweni kokukhulelwa komuntu, indima ekwakheni amathambo, kanye nendima ekuphulukisweni kwesilonda, phakathi kwabanye futhi ngaphezu kwendima yayo ekulawuleni isisindo.
Yini Ethinta Izinga Leptin?
Abacwaningi bathole ukuziphatha okuningi kanye nezici ezingakhuphula noma ukunciphisa amazinga we-leptin emzimbeni.
Ubukhulu kanye nokudla kokudla kubonakala kuthatha indima ekukhululweni kwe-leptin kusuka kumcubu we-adipose. Ngaphezu kwalokho, ukwakheka kokudla kubalulekile. Kwezinye izifundo, isibonelo, ukudla okunamafutha aphansi kubonakala sengathi kubangelwa amazinga aphakeme okusakaza i-leptin kunokudla okunamafutha aphezulu. Kukhona nobufakazi bokuthi iziguli ezikhuluphele ziye zaba yi-leptin-resistant, noma ziphikisana nemiphumela ye-leptin, ngakho-ke indlela evamile yokulawulwa kwezinto eziphilayo ezitshela umzimba uma sekuyisikhathi sokuyeka ukuphazamiseka.
Ukulala kancane kungathinta namazinga we-leptin, okuholela emazingeni aphansi nesifiso esikhulu (ukusebenza emakhonsathini ne-ghrelin, njengoba kuphawuliwe ngenhla). Ukuthola amahora ayisikhombisa ayisishiyagalolunye wokulala okungaphazanyiswa ubusuku bonke kubonakala sengathi kusiza ukugcina amazinga we-leptin lapho kufanele abe khona ekuphenduleni ukudla.
Njengoba kungase kucatshangwe, ngenxa yokuthi ikhono layo lokukhipha isisindo, ukuhlola okubheke ngezindlela ezehlukene zokusebenzisa i-leptin nemisebenzi yayo yokwelashwa kwe-pharmacologic sekuye kwaqhubeka isikhathi esithile futhi kuyingxenye yokuqhubeka okufuna ukubhekana nemithi yokwelapha okunomsoco ophumelelayo.
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