Isifo sikashukela kanye ne-Dementia
Ukuxhumana kucacile; abantu abane- type 2 yesifo sikashukela banengozi enkulu kakhulu yokuthuthukisa isifo se-Alzheimer kanye nezinye izinhlobo ze-dementia. Eqinisweni, kunesibopho esinjalo phakathi kwezifo ezimbili ezibizwa nge-Alzheimer's "Type 3 Diabetes " ngabanye.
Kodwa-ke, ucwaningo lwamuva lubonisa ukuthi kungase kube khona into esingayenza ngale ngozi.
Kwaphela iminyaka eminingana, abacwaningi bebelokhu behlola ukuthi kungenzeka ukuthi izidakamizwa ze-insulin zingasiza ekuphatheni isifo se-Alzheimer . Isibonelo, isifundo esisodwa sithole ukuhlangana phakathi kokwelapha nge-insulin yezifo zokwelapha kanye nesifo esinciphise somqondo wesifo sikashukela kubantu abanesifo sikashukela.
Isifundo
Esinye sezifundo zakamuva ekugqaseni kwesifo sikashukela kanye nesifo sengqondo somqondo sigxile ekutheni kunciphise ingozi yokuthuthukisa u-dementia, ngokuphambene nokwelashwa kwalesi simo ngemuva kokuba kuqale.
Abacwaningi eJalimane babuyekeze ukwaziswa kwomshuwalense wezempilo ezigulini ezingu-145,928 ezingaphezu kweminyaka engama-60 ngonyaka ka 2004- 2010. Bahlukanisa abantu ngamaqembu ahlukene:
- Ukungabi nesifo sikashukela
- Isifo sikashukela ngaphandle kokwelashwa yi-pioglitazone yezidakamizwa
- Ukuxilongwa kwesifo sikashukela esiphathwa yi-pioglitazone yezidakamizwa ezingxenyeni ezingaphansi kwezingu-8 zekhalenda
- Ukuxilongwa kwesifo sikashukela esiphathwa yi-pioglitazone yezidakamizwa ezingxenyeni ezingaphezu kwezingu-8 zekhalenda
Bese baqhathanisa izinga lokuthuthukiswa komqondo komqondo kulawo maqembu.
Imiphumela
Ngemuva kokuba idatha iqoqwe, imiphumela elandelayo itholakale:
1) Njengoba kulindelwe ngokusekelwe ocwaningweni olwedlule, ingozi ephezulu yokudangala komqondo kubantu abanesifo sikashukela yaqinisekiswa, kanti ingozi engama-23% yanda kakhulu uma kuqhathaniswa nalabo abangenayo isifo sikashukela.
2) Abantu abanesifo sikashukela ababephathwa nge-pioglitazone ezingxenyeni ezingaphezu kwezingu-8 zekhalenda babenciphise kakhulu ingozi yokuthuthukisa ukugula komqondo.
3) Eqinisweni, ingozi yabo yokudemeka kwengqondo yayingaphansi kwalabo abangenayo isifo sikashukela - ngu 47%. Ngamanye amazwi, abantu abane-long-term treatment of pioglitazone cishe babe yingxenye yengozi yokudangala komqondo uma kuqhathaniswa nabantu abangenayo isifo sikashukela.
4) Labo abanenkathi yokuphuza isikhathi esifushane ye-pioglitazone (engaphansi kwezingxenye eziyisishiyagalolunye zekhalenda) babonise ingozi efana nengculazi uma kuqhathaniswa nabantu abangenayo isifo sikashukela.
5) I-Metformin, esinye isidakamizwa esinikezwe ukwelashwa kwesifo sikashukela, sitholakale nokunciphisa ubungozi bokudemuka kwengqondo, kepha ngezinga eliphansi.
Lo mphumela othakazelisayo ukhombisa ukuthi ukusebenzisa i-pioglitazone kunganciphisa ingozi elandelayo yokudemokhrasi kubantu abanesifo sikashukela. Ucwaningo olwenzelwe ngokukhethekile ukuqinisekisa ukuthi imithi empeleni inika lesi sihlomulo manje siyadingeka. Ngenhlanhla, izifundo ezifana nalezi zivuselela ucwaningo olwedlulele mayelana nobuhlobo obuphakathi kwesifo sikashukela nokuwohloka komqondo.
Okuningi mayelana ne-Pioglitazone
I-pioglitazone (igama legama elithi Actos) liyimithi ekilasini lama- thiazolidinediones . Kunqunywe ukuphatha isifo sikashukela ngokuthuthukisa ukuzwela kwi-insulin.
Nakuba imiphumela yalolu cwaningo ibakhuthaza kakhulu, kube khona ukukhathazeka okukhonjiswe ekusetshenzisweni kwalesi sidakamizwa kubandakanya ukwehluleka kwenhliziyo , ukukhathazeka kwesibindi, umdlavuza wesisu kanye nencuba eyengeziwe yamathambo aphukile.
Ucwaningo oluqhubekayo
Ucwaningo oluningi luqhutshwa ekusetshenzisweni kwalo muthi ukwelashwa nokuvimbela ukucindezeleka komqondo. Vakashela i-US Clinical Trials ukubuka ukuhlolwa okuqhubekayo kwemitholampilo okuqhutshwa kuhilela i-pioglitazone.
Imithombo:
Ama-Annal of Neurology. 2015 Meyi 14. Imiphumela yomuthi we-pioglitazone ngezifo zengqondo. http://www.ncbi.nlm.nih.gov/pubmed/25974006
Deutsches Zentrum for Neurodegenerative Erkrankungen eV Isikhungo saseJalimane sezinkinga ze-Neurodegenerative ngaphakathi kwe-Association Helm Helmtz. Imithi yesifo sikashukela iyanciphisa ingozi yomqondo. Ifinyelele ngoJuni 25, 2015.https: //www.dzne.de/en/about-us/public-relations/meldungen/2015/press-release-no-8.html
Izikhungo zezempilo zikazwelonke. Ilabhulali Kazwelonke Yezokwelapha yase-US. I-Medline Plus. I-Pioglitazone. Februwari 15, 2014. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a699016.html