Ucwaningo lubonise ukuthi kukhona ukuxhumana phakathi kwesifo se- nicotine nesifo sofuba (IBD) . Kodwa-ke, yini ephazamisayo ukuthi ukubhema kubonakala kunemiphumela ehlukile ezinhlotsheni ezimbili eziyinhloko ze-IBD- ulcerative colitis nesifo sikaCrohn.
I-Connection Between Ulcerative Colitis Nokubhema
I-colitis ye-ulcerative ibizwa ngokuyinhloko njengesifo sabangabhemi.
Ababhemayo besikhathi eside basengozini enkulu yokuthuthukisa i-ulcerative colitis, kanti ababhemayo bamanje banengozi encane. Ukuthambekela kubonisa ukuthi ukubhema ugwayi kungavimbela ukuqala kokulonda kwe-ulcerative.
Abacwaningi bathole ukuthi yi-nicotine emigqonyeni kagwayi ephethe ithonya elihle emalinini we-ulcerative colitis. I-Nicotine yinto eyenzeka ngokwemvelo egwayi enomphumela oyinkimbinkimbi ezingxenyeni eziningi nezinhlelo emzimbeni. I-Nicotine nayo iyilutha kakhulu, futhi abantu abaningi ababhema ugwayi banzima ukushiya naphezu kwezinkinga ezinkulu zempilo.
Kuthiwa ukuthi i-nicotine egwayi iyathinta imisipha ebushelelezi ngaphakathi kolononi. Lo mphumela ungashintsha umthamo we-gut (izinga lapho impahla yokudla ihamba khona ngepheshana le-GI).
I-Nicotine ne-Crohn's Ills
Ukubhema ugwayi empeleni kunomthelela omubi kwisifo sikaCrohn. Abantu ababhema, noma ababhemayo esikhathini esidlule, banengozi enkulu yokuthuthukisa isifo sikaCrohn kunabangabhemi.
Iziguli ze-Crohn ezibhemayo zinezibalo eziphindaphindiwe zokuphindaphinda futhi ziphinde zihlinzekwe futhi zingadinga ukwelashwa okunamandla okukhukhumeza umzimba. Abantu abanesifo sikaCrohn bakhuthazwa kakhulu odokotela babo ukuba bayeke ukubhema ukuze bavimbele ukuhlaselwa kwesifo.
Umsizi wesibili
Ukubhema kwentuthuko kubantwana kunomphumela ekwenzeni i-IBD.
Izingane ezivezwe ngotshani wesibhamu zinciphise ingozi ye-ulcerative colitis kanye nengozi eyengeziwe yokuthuthukisa isifo sikaCrohn.
Ingabe Abangabokuqala Ukubhema Nge-Ulcerative Colitis Kuphinde Bakhanyise?
Ucwaningo oluthile lubonisile ukuthi ababhemayo bebadala abenza ukubola kwesilonda bese bebuyela emuva ekubhemeni babe nezimpawu ezimbalwa. Noma kunjalo, ukubhema ngokwayo kuthwala ezinye izingozi zempilo ezimbi. Odokotela bengenakululeka ukuthi isiguli siqale ukubhema, njengoba izingozi zokubhema zidlula noma yikuphi ukuzuzisa okungenzeka .
Kuthiwani Ngezimpawu Zama-Nicotine?
Manje ukuthi ama-nicotine (okubizwa nangokuthi i-nicotine transdermal) ayatholakala ekuqedeni ukubhema, kungenzeka ukutadisha imiphumela ye-nicotine yedwa ngaphandle kokuveza umzimba kwezinye izingozi zezempilo zokubhema. Umphumela womuthi uvame ukucwaningwa ngabacwaningi ngendlela yokuhlolwa eyaziwa ngokuthi isifundo esilawulwa ngokulawula indawo ye-placebo. Kulolu hlobo lokutadisha, ezinye iziguli zinikezwa izidakamizwa ezintsha kanti abanye banikezwa ukulungiswa kwama-dummy (placebo). Azikho iziguli noma odokotela abazitadishayo abazi ukuthi ngubani othola umuthi wangempela futhi othola i-placebo kuze kube yilapho isifundo sigcwalisiwe.
Kuzifundo ezimbili ezilawulwa yi-placebo ezimbili eziyimpumputhe, izintambo ze-nicotine zitholakala zibe ngcono kune-placebo ekunciphiseni ukukhululwa kwe-colitis.
Ngeshwa, imiphumela emibi eqenjini le-nicotine yayivamile futhi ihlanganisa ne-nausea, ikhanda elikhanyayo, nekhanda. Abahlanganyeli bokufunda ababengakaze baphuze bathole imiphumela emibi ikakhulukazi ephazamisayo.
Kwesinye isifundo, abantu abane-ulcerative colitis engakwesokunxele abangasabe besabela ekwelashweni nge-mesalamine yomlomo banikezwa i-nicotine esetshenzisiwe kanye ne-mesalamine enemas. Le nhlanganisela entsha yayiphumelele ekunciphiseni ukuxolelwa kwabafundi abangu-12 kwabafundi abangu-15.
I-Nicotine ayibonakali inenzuzo njengokwelashwa kwesondlo; kungase kungasiza iziguli zihlale ekuxoxweni. Kunalokho, kubonakala sengathi kunomthelela omuhle ezifweni ezisebenzayo (ama- flare-ups ).
Ukuvimbela imiphumela emibi evela kulesi sikhwama, abacwaningi bahlakulela izindlela zokukhulula i-nicotine ngqo ekoloni. Esicwaningweni esisodwa, i-capsule ye-nicotine yadalwa ukuze isebenze ngokuqondile emgqeni esikhathini esingamahora angu-6.
Lokho Konke Kukusho Kubantu Abanobuchopho Bokulondeka?
Umphumela we-nicotine ngokulonda kwe-ulcerative isacacile, kodwa unikeza isiqondiso esithembisayo sokuthuthukiswa kwezidakamizwa ezintsha. Njengoba indima ye-nicotine ekoloni iqondakala kangcono, iziguli ezine-ulcerative colitis zingase zizuze ngelinye ilanga izinqubo ezintsha ezisekelwe kulo mphumela.
Imithombo:
I-Green JT, u-Evans BK, uRhodes J, et al. "Ukwakhiwa komlomo nge-nicotine ukukhululwa nokuxoshwa ekoloni: ukuthuthukiswa kwayo kanye ne-pharmacokinetics." Br J Clin Pharmacol Okthoba 1999; 48: 485-493. 28 Meyi 2009.
Mahid SS, Minor KS, Stromberg AJ, Galandiuk S. "Ukubhema okusebenzayo nokungabonakali ebuntwaneni kuhlobene nokuthuthukiswa kwesifo sofuba esiswini." I- Inflamm Bowel Dis Apr 2007 13; 431-438. 28 Meyi 2009.
Pullan RD, Rhodes J, Ganesh S, et al. "I-nicotine yokudlulisela isifo se-ulcerative colitis." N Engl J Med Mar 1994; 330: 811-815. 28 Meyi 2009.
Sandborn WJ, Tremaine WJ, Offord KP, et al. I-nicotine eguquguqukayo yokwelashwa kwesilonda esibucayi ngokulinganayo kuya ngokulinganayo. "Isivivinyo esilawulwa ngokungahleliwe, esiphambene naso-blindbo,". U- Ann Intern Med Mar 1997; 126: 364-371. 28 Meyi 2009.
Sandler RS, Sandler DP, McDonnell CW, Wurzelmann JI. "Ukuchayeka kwengane ekubhemeni kwentuthu kagesi kanye nengozi ye-ulcerative colitis." Am J Epidemiol Mar 1992; 135: 603-608. 28 Meyi 2009.