I-Compazine, i-Thorazine, ne-Reglan yokuhlasela kwe-Migraine nge-Nausea
Abantu abangaphezu kwesigamu bahlakulela isisulu sokunambitheka nokuhlanza ngesikhathi sokuhlasela kwe-migraine. Njengoba i-neurotransmitter dopamine ibilokhu ithathwa njengomkhulumeli omkhulu we-nausea ngesikhathi i-migraine, imithi evimbela i-dopamine receptors (ebizwa ngokuthi abaphikisi be-dopamine) iphumelela ekunciphiseni ukuhlanzeka nokuhlanza. Ngokuthakazelisayo, lezi zidakamizwa zinciphisa ubuhlungu be-migraine, ngakho-ke zivame ukusetshenziselwa ukwelashwa okuwukuphela kokwelashwa okukhulu kwe-migraines.
I-Compazine ku-Migraine Treatment
Ama-Antipsychotics afana neCompazine (prochlorperazine) avame ukusetshenziswa ukuphathwa kwe-migraines ezinzima nge-nausea ehambisanayo.
Ngaphandle kokwelapha isicuphoso esinzima nokuhlanza, i-Compazine isetshenziselwa ukwelashwa kwe-schizophrenia kanye nokwelapha okwesikhashana kokukhathazeka okungapheli okungokwengqondo kwengqondo. I-Compazine iyatholakala njengamaphilisi, ama-capsules akhishwe-asekelwe, ifomu eliketshezi lomlomo, ama-suppository nama-vials - anikezwa nge-intravenously (nge-vein) noma nge-intramuscularly (ngaphakathi emisipha). Ngenxa yobunzima bemithi yomlomo ne-nausea ehambisana ne-migraine kanye nokuhlanza, i-Compazine inikezwa nge-intravenously noma intramuscularly ukuze uthole imithi yokuphumula - ngokuvamile endaweni yokuphuthumayo, isikhungo sokunakekelwa okuphuthumayo, noma emtholampilo.
Imiphumela emibi ye-Compazine ihlanganisa ukulala, isiyezi, umbono ongenangqondo, ukusabela kwesikhumba, ukucindezelwa kwegazi okuphansi kanye ne-amenorrhea. Imiphumela ye-Extrapyramidal ingase ibe khona njengama-spasms we-muscle, ukuphumula, i- parkinsonism , noma i-tardive dyskinesia.
Ukusabela okungavamile kodwa okungasongela impilo kuCompazine (nezinye izifo ezithathelwanayo nge-antipsychotics) yi-Neuroleptic Malignant syndrome, okubangela izimpawu ezihlukahlukene ezibandakanya imfiva, ukuqina kwemisipha nokudideka.
I-Thorazine ku-Migraine Treatment
I-Thorazine (i-chlorpromazine) yinye i-antipsychotic ngezinye izikhathi esetshenziselwa ukuphatha imithi eqhamukayo kanye ne-nausea ehambisanayo nokuhlanza.
NjengeCompazine, ivame ukunikezwa ngokungahambi kahle noma ngokungahambisani nesimo sokuxhaswa kwe-migraine ne-nausea. Ngokwezinzuzo zayo, ngokusho kuka-2013 ku- Journal of Emergency Medicine , iTrarazine yathuthukisa ubuhlungu bekhanda, ubuhlungu obufisayo, nokuzwela ukukhanya nokuzwakala kubantu abane-migraine uma kuqhathaniswa nabantu abathatha indawo ye-placebo. Kodwa kulolu cwaningo, abantu abaningi babhekana nokulala nokuzondwa lapho bema lapho bethatha iTrazine, uma kuqhathaniswa nabantu abathola i-placebo.
Reglan ku-Migraine Treatment
I-Reglan (i-metoclopramide) ibuye ivimbele i-dopamine receptors. Kodwa ngokungafani nezinye antipsychotics, isetshenziselwa ukwandisa umkhuhlane wezinyosi kubantu abanenkinga yokususa isisu sabo, njengabantu abanesifo sikashukela. Ngokufana neCompazine, i-Reglan nayo isetshenziselwa ukwelapha isisu sokuhlanzeka nokuhlanza, ikakhulukazi ekamelweni eliphuthumayo noma esimweni sokunakekelwa okuphuthumayo, futhi siyasebenza ngempela. Eqinisweni, isifundo sokuhlaziywa kuka-2013 Cochrane sitholile ukuthi ukuhlanganiswa kukaRemlan kanye ne-aspirin kuthuthukise ukuhlanzeka okuhambisana nokufudumala kwe-migraine nokuhlanza ngemiphumela emibi uma kuqhathaniswa ne- triptan Imitrex (sumatriptan).
Nakuba u-Reglan ejwayele ukuba nemiphumela emibi kakhulu kunezinye izidakamizwa, ezivamile zihlanganisa:
- ukuphumula
- ukhathala
- isiyezi
- ikhanda
- ukudideka
- izinkinga zokulala
Njengo-Compazine, imiphumela emibi kakhulu njengezimpawu ze-extrapyramidal ne-Neuroleptic Malignant Syndrome ingenzeka (kakhulu engavamile). Futhi, i-Reglan ingandisa ingozi yomuntu yokucindezeleka nokuzibulala.
Ngaphansi
Ngokuzihlambalaza nokuhlanza okuhambisana ne-migraine, imithi evimbela i-dopamine receptors ebuchosheni (i-dopamine antagonists) isetshenziswa kakhulu, ikakhulukazi i-Compazine, i-Thorazine noma i-Reglan. Nakuba isebenza kahle, le mithi ibeka ingozi. Qinisekisa ukwazisa udokotela ukukuphatha zonke izinkinga zempilo kanye nemithi, kuhlanganise namavithamini, izithako ezithengiswayo, kanye nemithi yokwelashwa engaphezulu.
Imithombo:
I-Bigal ME, i-Bordini CA & i-Speciali JG. I-chlorpromazine engathandeki emnyangweni ophuthumayo ukwelashwa kwe-migraines: isilingo esilawulwa ngokungahleliwe. J Emerg Med . 2002 Aug; 23 (2): 141-8.
I-Flake ZA, i-Linn BS ne-Hornecker JR. Ukukhethwa okuwusizo kwe-antiemetics esimweni sokuthungula. Am Fam Physician 2015 Mar 1; 91 (5): 29306.
ULáinez M JA, García-Casado A & Gascón. Ukuphathwa kahle kwezinhlanzi ezinkulu nokuhlanza ku-migraine: ngcono imiphumela yeziguli. Iziguli zohlobo lwe-Relat Iziphumo . 2013; 4: 61-73.
Ukuphathwa kwe-US nokuDrug. Umhlahlandlela wemithi: Compazine. Kufinyelelwe ngo-February 4th 2016.
Ukuphathwa kwe-US nokuDrug. Umhlahlandlela wemithi: Reglan (umjovo we-metoclopramide). Kufinyelelwe ngoFebhuwari 5, 2016.
QAPHELA: Ulwazi olukulesi sayithi lunguzinhloso zemfundo kuphela. Akufanele isetshenziswe njengengxenye yokunakekelwa ngumuntu udokotela olayisenisi. Sicela ubheke udokotela wakho ukuze ahlolwe futhi aphathwe noma yiziphi izimpawu noma isimo sezokwelapha .