Izimpawu, Ukuxilongwa, Nokuphathwa Kwe-Vasculitis Ehlobene Ne-Lupus
Yini ngempela i-vasculitis futhi kungani kubalulekile kubantu abane-lupus? Yiziphi izimpawu ongazilindela futhi zingaphathwa kanjani?
I-Vasculitis Ehlobene ne-Lupus - Incazelo
I-Lupus (i-systemic lupus erythematosus) yisimo lapho ama-antibodies ahlasela khona amathishu akho. Lezi zinambuzane zingahlasela cishe noma yiziphi izicubu zomzimba, kuhlanganise nemithwalo yegazi.
I-Vasculitis ilula ukuyiqonda ngokuqeda leli gama libe yi-"vascu" lisho okuhlobene nemithambo yegazi, futhi "itis" okusho imithwalo yegazi. Ngakho-ke, i-vasculitis ukuvuvukala kwemithambo yegazi eyenzeka ngenxa yamagciwane okuvikela amasosha omzimba.
I-Vasculitis ingathinta noma yiluphi uhlobo lwezitsha zegazi; imishanguzo ephethe igazi esuka enhliziyweni kuya ezinhlobonhlobo, imithanjeni ebuyisela i-deoxygenated igazi kusukela ezicukwaneni kuya enhliziyweni, kanye nama-capillaire amancane angashadile, amancane kakhulu emithanjeni yegazi lapho ukushintshaniswa kwe-oxygen ne-carbon dioxide, kanye izakhi, zenzeka.
Abantu abangamaphesenti angu-11 kuya ku-36 abantu abane-lupus bazokwakha ama-vasculitis kwezinye izicubu nakwezinye iziqu.
Kungani Vasculitis Inkinga?
I-Vasculitis ingaba yisimo esibi kakhulu ngezindlela ezimbalwa ezahlukene. Ukuvuvukala kwesitsha segazi kungabangela ukuba kube lula futhi kuholele ukugeleza kwegazi kuzicubu i-blood vessel ekhonzayo.
Ngezinye izikhathi izitsha zegazi zingagcina ngokuphelele.
Ngezinye izikhathi, ukuvuvukala kungabangela ukuthi imithwalo yegazi ilula futhi ifinyelele. Izifo ezinomphumela eziphuthumayo zingase ziqhume, zidale ukulimala kwangaphakathi kanye nokulimala kwezicubu.
Izimbangela ze-Vasculitis
I-Lupus yimbangela eyodwa ye-vasculitis, ene-autoantibodies emithonjeni yegazi ephazamisa i-lupus.
I-Vasculitis ingase isenzeke ngenxa yokuphendula okweqile emasongweni ezitsheni noma ngenxa yokutheleleka kwezindonga zamathambo wegazi.
Izimpawu ze-Vasculitis Ngenxa ye-Lupus
Izimpawu ezivamile ze-vasculitis kufanele zijwayele abantu abahlushwa ukuvuvukala: umkhuhlane, ukuvuvukala, i-malaise, nokukhathala. Kodwa izibonakaliso ezithile nezimpawu ezithile zivame ukuxhomekeka ukuthi kuphi nokuthi yiluphi uhlaka oluthinta imithwalo yegazi olusebenzayo nokuqina kwesibindi. I-Vasculitis ithinta ezinye izitsha zegazi emzimbeni kakhulu kunabanye. Isibonelo, izinso zivame ukuthinteka ku-lupus, kodwa i-vasculitis yemithambo yegazi ezintsheni ayivamile.
Ezinye izimpawu ezihlobene nezitho ezihlukahlukene emzimbeni zihlanganisa:
I-Skin - Vasculitis ehlanganisa imithwalo yegazi yesikhumba ingabangela:
- Amachashazi abomvu noma aphuzi, ngokuvamile eningi emilenzeni (Lokhu kwenzeka lapho imithwalo encane yegazi ethinteka yi-vasculitis iba buthakathaka futhi iphule)
- Amabala amakhulu abukeka njengemivimbo emikhulu
- I-Hives (engavamile)
- I-itchy lumpy rash (engavamile)
- Izimpumputhe ezibuhlungu noma zethenda (Lokhu kungase kwenzeke lapho imilayezo yegazi ekhulu kakhulu isula bese ivuvukala ngaphansi kwesikhumba)
Amalunga - Ukubandakanywa kwemithambo yegazi yamalunga (vasculitis) kuvamile futhi kungafaka:
- Ubuhlungu nokukhungula ngenxa yokuvuvukala
- Ukuvuvukala nokushisa ukuzwa
I-Brain - Vasculitis ethinta isimiso sezinzwa esiyinhloko ithinta cishe amaphesenti angu-10 abantu abane-lupus futhi mhlawumbe i-complication ejulile kakhulu ehlobene ne-lupus. Isistimu ye-central central isifo se-lupus ingahlobene ne-vasculitis noma ingaba umphumela oqondile we- autoantibodies ngokumelene nezinye izicubu ebuchosheni. I-Vasculitis ebuchosheni ingabangela izimpawu ezihlukahlukene ezihlanganisa:
- Izinsizwa
- Ukuphazamiseka kokuziphatha
- Ukudideka
- Ukuzizwa
- Izibhamu
Inhliziyo - Izimpawu ezihlobene ne-vasculitis enhliziyweni kusuka ku-lupus zivamile, kodwa zingabangela ukukhululeka esifubeni, ikakhulukazi lokho okuqhubekayo ngokuzikhandla nokukhululeka ngokuphumula.
Amapulazi - I-Vasculitis yamaphaphu angabangela ukutholakala komkhuhlane, ukukhwehlela, nesifuba se-x-ray okufana ne-pneumonia. Kungase futhi kubangele ukukhwabanisa kwamapayipi (fibrosis) nokuphefumula okungapheli.
I-Eye - Vasculitis emehlo ahlobene ne-lupus ngokuvamile ihlotshaniswa nemithambo encane yegazi ku-retina. Lokhu akubangeli ngaso sonke isikhathi izimpawu, kepha uma kwenzeka kungabandakanya:
- Umbono ogqamile oza ngokuzumayo futhi uqhubeka
- Ukulahleka kombono
Izinkinga ze-Lupus Vasculitis
Uma izitsha ezincane zegazi zithinteka yi-vasculitis nge-lupus, izimpawu ezivame kakhulu zihlanganisa izindawo ezibomvu noma ezibomvu esikhumbeni esikukhulunywe ngenhla. Izinkinga ezinkulu azivamile futhi zingabandakanya:
- I-mesenteric vasculitis - Uma i-mesentery ("ingubo" yezicubu ezixhumeneyo ezungeze izitho zangasese) ithintekile, umonakalo emathunjini kungenzeka ukuthi ungacatshangwa ngokuthi "isifo sokugoma emathunjini."
- Ukwehla kwesisu - Ukubandakanywa kwemithambo yegazi emikhulu emaphashini kungabangela ukubola kwegazi emathangeni amaphaphu.
- I-multiplex i-multiplex - I-mononeuritis multiplex ukuvuvukala kwemizwa emibili noma ngaphezulu evame ukubangela ubuhlungu obujulile, buhlungu, nezimpawu ezihlobene nezinzwa ezithintekile, ezifana nokudonsa inyawo.
Ukuxilongwa kwe-Lupus ehlobene ne-Vasculitis
Ukuxilongwa kwe-vasculitis ehlobene ne-lupus kungaba inselele, futhi izimpawu ezifanayo zingenzeka ngenxa ye-vasculitis noma ezinye izinqubo (imiphumela eqondile ye-autoantibodies kuma-tishu) atholakala nge-lupus.
Ukuhlolwa kwegazi kungahle kubheke izibonakaliso ezingezona ezithile zokuvuvukala. Izivivinyo ezihlanganisa inani eliphelele legazi, umsebenzi wezinso, nokuhlolwa komsebenzi wesibindi nakho kwenziwa. Izingcaphuno zenhliziyo nobuchopho (njenge- echocardiogram noma i-MRI angiography) zingabonisa ukuthi kune-aneurysms ehlobene ne-lupus. Lezi zifundo zelabhu nezithombe zokuhlola zihlolwa ngokubambisana nomlando oqaphele nokuhlolwa ngokomzimba ukuze kutholakale ukuxilongwa kwe-vasculitis.
Ngezinye izikhathi i-biopsy yenzeka ukucacisa ukuthi ukulimala kwezicubu kuhlobene yini ne-vasculitis.
Izinketho zokwelapha ze-Vasculitis ezihlobene ne-Lupus
Izinhlobo eziningi ze-vasculitis zelashwa uma zitholakala ngaphambi kokulimala komzimba okukhulu. I-Corticosteroids nezinye izidakamizwa zokuzivikela zivame ukusetshenziselwa ukunciphisa ukuvuvukala kwemithambo yegazi. Ngezinye izikhathi, uma imithi ye-steroid ingasebenzi, imithi efana nalabo asetshenziselwa abantu abane-leukemia kanye ne-lymphomas (isibonelo, rituximab ) ingaba usizo.
Ukuze unqume ukuthi umuntu une-vasculitis, uchwepheshe wezokwelapha uzobukeza umlando wezokwelapha, ahlole ukuhlolwa ngokomzimba futhi acele ezinye izivivinyo ze-lab ezikhethekile, kungakhathaliseki uhlobo lwe-vasculitis, kuhlanganise nokubala okuphelele kwegazi, ukuhlolwa kwe-urinalysis, nokuhlolwa komsebenzi wesibindi.
Ukubikezela ku-Lupus Associated Vasculitis
Esikhathini esiningi, ukwenza ukuthi ukuxilongwa nokuqala ukwelashwa kunganciphisa ukuvuvukala emithanjeni yegazi ehambisana ne-vasculitis. Ngezinye izikhathi, lesi simo singase sibangele izinkinga ezinkulu, njengalezo ezihlobene nokubunjwa kwezifo ezinamandla. Ngenkathi ukwelashwa kungasebenza, i-vasculitis yisimo esingapheli lapho ukulawula, kunokuba ukwelaphe, kuyindlela yokuphatha.
Ngaphansi kwe-Vasupitis ehlobene ne-Lupus
I-Vasculitis ehlobene ne-lupus ingaholela ezinhlobonhlobo eziningi zezibonakaliso, futhi ibangele izinkinga ezinkulu ezihlobene nesitsha segazi esincane kanye ne-aneurysms. Ukuxilongwa kungaba nzima futhi kuvamise kwenziwe ngokusekelwe kokuhlanganiswa kokuthola.
Nakuba i-vasculitis ingase ibe yingozi kakhulu, imithi ye-immunosuppressive inganciphisa ukuvuvukala futhi ingasiza ekuvimbeleni ezinye zezinkinga ezingenzeka.
Kusukela ukunakekelwa kwezempilo kwangaphambili kungenza umehluko nge-lupus ehlobene ne-vasculitis, ukuba nobuhlobo obuhle nodokotela wakho nokuba ngummeli wakho ekunakekeleni kwakho kungenza umehluko. Hlola lawa macebiso ekusebenzeni okusemandleni akho nge-lupus nsuku zonke .
> Imithombo
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- > Kasper, uDennis L .., u-Anthony S. Fauci, noStephen L .. Hauser. Izimiso zikaHarrison zeMithi yangaphakathi. I-New York: Imfundo ye-Mc Graw-Hill, 2015. Phrinta.
- > Shinjo, S., no-E. Bonfa. I-Vasculitis encane kwi-Systemic Lupus Erythematosus: Inhlangano ne-Anti-Ribosomal P Protein Antibody noRaynaud Phenomenon. I-Rheumatology yezokwelapha . 2011. 30 (2): 173-7.