I-Fibrate, eyaziwa nangokuthi i-fibric acid derivatives, yilasilasi lezidakamizwa ezinciphisa i-lipid ezikwazi ukuphazamisa zonke izici zephrofayili yakho ye-lipid.
Indlela i-fibrates ephansi ye-cholesterol eyinkimbinkimbi ngayo. I-Fibrate yenza kusebenze iphrotheni ebizwa ngokuthi i-peroxisome proliferator-activated alpha receptor (PPAR-alpha). Le phrotheni ingenza kusebenze enye i-enzyme, i-lipoprotein lipase, eyanciphisa inani le- apolipoprotein C-III emzimbeni.
Ekugcineni, lokhu kuholela ekunciphiseni ukwakheka kwe- VLDL kanye ne-triglycerides futhi kwandisa ukwehla kwe-lipids. Ama-Fibrate nawo akhula emazingeni e- HDL ngokukhulisa inani le- apolipoprotein AI ne-A-II eyenziwa emzimbeni.
Kukhona okwamanje izidakamizwa ezimbili ze-fibrate ezivunyelwe ukusetshenziswa yi-Food and Drug Administration (FDA) e-United States:
- I-Gemfibrozil (i-Lopid)
- Fenofibrate (Tricor)
Ama-fibrate ayaziwa kakhulu ngokunciphisa i-triglycerides nokwandisa i-HDL cholesterol. Noma kunjalo, zingathinta zonke izici zephrofayela yakho ye-lipid. Ngokuvamile, i-fibrates inga:
- Yehlisa amazinga wakho we-LDL ye-cholesterol ngamaphesenti angu-5 kuya kumaphesenti angu-20.
- Ukwandisa i-cholesterol yakho ye-HDL noma yikuphi phakathi kwamaphesenti angu-10 kuya kuma-35 amaphesenti.
- Nciphise amazinga akho e-triglyceride ngamaphesenti angu-20 kuya kuma-50%.
Ukuze uphuthukise ngempumelelo iphrofayela yakho ye-lipid, i-fibrate ingathathwa yedwa noma ihlanganiswe namanye ama-agent aphansi aphansi, njenge-statins noma i-omega-3 fatty acids.
Indlela Okufanele Uyenze Ngayo Imfucuza
Kumele uthathe i-fibrate yakho njengoba nje enqunywe ngumhlinzeki wakho wezempilo futhi kufanele uqiniseke ukuthi awuphuthelwa noma yimaphi amanani. Zonke imithi ye-fibrate iyatholakala kwifomu yethebhulethi futhi ithathwa ngomlomo. Nakuba ungathatha kokubili izinhlobo ze-fibrate noma ngaphandle kokudla; Kodwa-ke, ucwaningo luye lwabonisa ukuthi ukuthatha i-fibrate, i-gemfibrozil, ngokudla kusiza ukwandisa ukungena kwayo.
Kumele futhi uqiniseke ukuthi ungaphuthelwa noma yikuphi kokuqokwa kwakho nomhlinzeki wakho wezempilo, ngoba uzodinga ukuqapha ukuthi imithi iyasebenza yini noma cha. Umhlinzeki wakho wezempilo uzodinga ukwenza izinguquko ekwelapheni kwakho kwehlisa i-lipid, kuye ngokuthi usabela kanjani kumuthi. Ngenkathi uthatha ama-fibrate - nanoma imuphi omunye ukwelashwa kwehlisa i-lipid - kufanele futhi ulandele eduze kokudla ukuze unciphise i-cholesterol yakho ne-triglycerides.
Zikhona Nemibizo Yomuntu Okumele Uyifunayo?
Nakuba i-fibrate ibekezelela kakhulu abantu abayithatha, ungase uhlangabezane neminye imiphumela emibi ngokuyithatha, Imiphumela emibi kakhulu evezwe ifaka phakathi nokubhekana nezinkinga zomzimba, njengezinambuzane, isifo sohudo, nobuhlungu besisu. Lezi zithinta ngokuvamile ziba mncane futhi, ezimweni eziningi, hamba ngemva kokuqala i-fibrate yakho.
Kwezinye izimo, i-fibrate ingakwandisa ama-enzyme yesibindi sakho, ngakho-ke ngaphezu kwe-lipids yakho, umhlinzeki wakho wezempilo uzophinde aqaphele ama-enzyme enyama yakho ngezikhathi ezithile. Uma une-gallbladder disease, kufanele uvumele umhlinzeki wakho wezempilo ukuba azi, ngoba kukhona ingozi encane yokuthuthukisa ama-gallstones ngenkathi ethatha i-fibrate. Ama-Fibrate angabangela futhi isimo esibizwa ngokuthi i-rhabdomyolysis.
Nakuba kungavamile, ingozi yokuthuthukisa lesi simo ngenkathi ithatha ama-fibrate ukwanda uma uthatha imithi ethile kanye ne-fibrate yakho noma unempilo ethile.
Ama-Fibrate angakwandisa amathuba okuthola igazi lapho uthatha igazi elincane, njengeCoumadin ( warfarin ). Ngenxa yalokhu, umhlinzeki wakho wezempilo uyokwazi ukulungisa umthamo wakho ngenkathi ethatha ama-fibrate.
Imiphumela emibi etholakala yi-fibrate ngokuvamile iyomnene, kodwa kufanele ihanjiswe kumhlinzeki wakho wezokunakekelwa kwempilo uma ihlupha noma iqhubeka isikhathi esithile. Kufanele uvumele umhlinzeki wakho wezempilo ukuba azi noma yimiphi imithi oyithathayo - kuhlanganise nanoma yimiphi imikhiqizo ye-herbal noma ngaphezulu-noma izimo zezokwelapha onokukwazi ukukuqapha eduze ngesikhathi sokwelapha.
Imithombo:
> Dipiro JT, Talbert RL. I-Pharmacotherapy: Indlela Yokuthola Pathophysiological, 9th 2014.
UMalloy MJ, Kane JP. Amagciwane asetshenziswe ku-Dyslipidemia. Ku: Katzung BG, Trevor AJ.eds. I-Basic & Clinical Pharmacology, 13e . ENew York, NY: McGraw-Hill; 2015.