Ukutadisha izilinganiso kubonisa ukuthi kungenzeka ukuthi i-calcitonin ingaba ukwelashwa kwe-osteoarthritis.
I-osteoarthritis ithinta abantu abayizigidi ezingu-21 e-United States, okungamaphesenti angaba ngu-10 abantu baseMelika. Ukwelashwa kwe-osteoarthritis kuye kugxila ebuhlungu bokulawula obuhlobene nokulahlekelwa kwe-articular cartilage, i-subchondral sclerosis, nokwakhiwa kwama- osteophytes . Kube khona izidakamizwa noma ukwelashwa okwakwazi ukukhomba inqubo yokubhujiswa okuhlangene nakuba.
Isidakamizwa esetshenziswa kakhulu ukuphatha isifo se-Paget se-bone kanye ne- osteoporosis singase sikwazi ukuphuza noma ukulwa nomonakalo we-cartilage. Yilokho abacwaningi abasifunayo. Isidakamizwa i-calcitonin futhi i-hormone yama-amino acid eyenziwa yi- thyroid . I-Calcitonin inqunywe njenge-spray yangasese noma umjovo.
I-Calcitonin Ukufundwa Kwama-Female Rats
Abacwaningi bazama ukunquma ukuthi i-calcitonin ingaba yisidakamizwa esiyisifo esetshenziswa ukuphatha i-osteoarthritis. Ukucwaninga kwakamuva kwamagundane abesifazane kwenza abacwaningi baphetha ngokuthi i-calcitonin ingavikela abesifazane base-postmenopausal ebuhlungu obuqhubekayo nokukhubazeka okuboshwe ekubhujisweni okuhlangene.
Ucwaningo lwalugxile kumagundane e-ovariectomized, abacwaningi abathi bahambisana nokunqamuka komuntu. Ukulahlekelwa kwe-estrogen kuye kwahlotshaniswa nokubola kwe-cartilage. Esicwaningweni kwakukhona amaqembu ama-5 okucwaninga kwamagundane. Kwakukhona amagundane ayenayo:
- i-ovariectomy
- i-ovariectomy kanye ne-60-day release ye-estrogen pellet efakiwe
- i-ovariectomy plus 2 mg / kg ye-salmon calcitonin ne-5CNAC (i-agent yokuletha)
- i-ovariectomy plus i-5CNAC
- inqubo ye-sham
Ama-sampuli egazini athathwe ngezikhathi ezithile kusuka kwamagundane nesisindo somzimba saqoshwa. Emasontweni angu-9, amagundane ayexhumene futhi ahlaziywa. Wonke amagundane e-ovariectomized wabonisa ubufakazi bokuphulukiswa kwe-articular cartilage esheshayo.
Ukwelashwa kwe-Estrogen kuthintana nesilinganiso sokwanda kwehlazo. I-Calcitonin yasebenza kangcono nakakhulu.
Iziphetho Mayelana neCalcitonin
Abacwaningi baphetha ngokuthi i-estrogen ne-calcitonin ivikelekile ekubhekaneni nezinyathelo zomzimba we-knetilage. I-Calcitonin isebenze kangcono ngokuvimbela ngokuphelele ukukhushulwa. Ukwelashwa kwe-Calcitonin kungabhekana kokubili ukusheshisa kokuqothulwa kwe-cartilage nokwandisa ezindaweni ezibonakalayo. Izilingo ezizayo zizofuna ubufakazi obengeziwe.
Abanye abacwaningi, ekucabangeni umthelela walezi zifundo ezitholakala kwi-osteoarthritis yabantu, bazibuza ukuthi umphumela we-calcitonin nge-cartilage wawuzoba yini ukuvimbela kunokuthi ukwelashwa, kunenzuzo enkulu kunazo zonke ezenzeka e-osteoarthritis yokuqala. Kumele kuqashelwe ukuthi ngezinye izikhathi izilwane zezilwane zihluleka ukunikeza imiphumela ethembisayo kubantu, kodwa ngalesi sikhathi isifundo se calcitonin sinikeza ithemba lokuthi kungenzeka kube khona ukhetho olusha emgwaqweni.
Umthombo:
Umphumela we-Oral Calcitonin nge-Cartilage Inguquko kanye ne-Surface Erosion ku-Rat Ovariectomized. I-arthritis ne-Rheumatism. Agasti 2007.