Ukukhathala kungenye yezibonakaliso ezivame kakhulu ze- Multiple Sclerosis (MS) , futhi kungase kube nzima kakhulu futhi kube nzima-ngezinye izikhathi ngisho nangaphezulu kunezimpawu zangokomzimba ze-MS, njengokungathi ubuthakathaka obuthakathaka noma izinkinga zokulinganisela.
Ngaphezu kokukhubaza, ukukhathala okuhlobene ne-MS kuyisimo esiqine kakhulu ukuphatha. Nakuba i-Provigil (i-modafinil) ne-Symmetrel (i-amantadine) ivame ukushiwo ukukhathala kwe-MS, abukho ubufakazi obuningi besayensi bokusekela ukusetshenziswa kwabo.
Futhi, le mithi inemiphumela emibi engathandeki. Isibonelo, i-Provigil (i-modafinil) ingabangela ubuthongo, okungabangela ukhathala komuntu. Cabanga ukuthi uphakamise ubusuku bonke-lokhu kuzoqhubeka ukuqhubeka, hhayi usizo, ukukhathala kwakho.
Ngakho-ke iningi lezazi ze-MS (nabantu abahlala ne-MS) bafuna ngokuphuthumayo isisombululo sokulwa nokukhathala kwe-MS. Nakuba imikhuba yokuzivocavoca efana nokuzivocavoca ibonise isithembiso, abaningi bafuna "iphilisi yokulwa nokukhathala."
Coenzyme Q10
I-Coenzyme Q10 , eyaziwa nangokuthi i-CoQ10, i-antioxidant etholakala cishe kuwo wonke amaseli emzimbeni wakho. Njengoba i-antioxidant, iyanqanda ama-radicals amahhala, angalimaza amangqamuzana emzimbeni wakho. Ngokulwa nama-radicals amahhala, i-coenzyme Q10 ikholelwa ukuthi igcina amangqamuzana aphilile, athuthukisa ukusebenza kwawo kanye nesimo se-metabolism.
I-Coenzyme Q10 nayo ikholelwa ukuthi inezindawo zokulwa nokuvuvukala. Lokhu kusho ukuthi kunganciphisa isimiso somzimba sokuzivikela somuntu, esingazi ukuthi sisebenza ngokweqile kumuntu onama-MS.
Eqinisweni, ucwaningo luye lwabonisa ukuthi ukwesekwa nge coenzyme Q10 kunciphisa izimpawu ezithile zokuvuvukala, njenge- tumor necrosis factor (TNF) , egazini legazi.
Ngakho-ke, ingabe isithasiselo esifana ne-coenzyme Q10 sinciphisa ukukhathala kwakho okuhlobene ne-MS noma okuthandayo? Kungase kudingeke uzame, ngokusho kwesinye isifundo. Uma sekushiwo, qiniseka ukuthi uxoxisana noma yimuphi umfakisicelo omusha noma imithi nodokotela wakho kuqala ukuqinisekisa ukuthi iphephile futhi kufanelekile kuwe.
Ukwelapha ukukhathala kwe-MS ne-Coenzyme Q10
Esifundweni sika-2016 ku- Neuroscience yezokwelapha, abahlanganyeli abangu-45 abane-multiple sclerosis babenomsebenzi wokuthola ama-500mg we-coenzyme Q10 noma iphilisi ye-placebo nsuku zonke amasonto angu-12. Ucwaningo lwaluphuphutheke kabili, okusho ukuthi abahlanganyeli noma abaphenyi ababazi ukuthi ngubani othole i-coenzyme Q10 ngokungawutholi iphilisi ye-placebo.
Ekuqaleni kwesifundo, isikali esivame ukusetshenziselwa ukulinganisa ukukhathala ku-MS (esibizwa ngokuthi ukukhathala kwesisindo) sanikwa bonke abahlanganyeli. Yabe isetshenziswa futhi ekugcineni kwesifundo (emavikini angu-12).
Ukukhathala Okukhathala Kwesisindo (FSS) siqukethe izitatimende eziyisishiyagalolunye ezitholakala esikalini esingamaphuzu ayisikhombisa, ngencazelo eyodwa "ayivumelani neze" futhi okuyisikhombisa kusho "ukuvuma ngokuqinile." Amaphuzu ajwayelekile yilawa manani ayisishiyagalolunye, anezibalo eziphakeme ezibonisa ukukhathala okukhulu.
Isitatimende sesibonelo esivela esikalini "ukukhathala kuphazamisa umsebenzi wami, umndeni, noma impilo yomphakathi." Uma uvumelene kakhulu nalesi sitatimende, uzobe ushaya amaphuzu angu-7 (amaphuzu aphezulu).
Imiphumela yocwaningo yathola ukuthi abahlanganyeli abathatha i-coenzyme Q10 banomtholampilo ophawulekayo kumaphuzu abo we-FSS-lokhu kusho ukukhathala kancane-uma kuqhathaniswa nabahlanganyeli abathatha ipilisi ye-placebo.
Ukwelapha Izimpawu Ezicindezelayo ku-MS Nge Coenzyme Q10
Esikhathini esifundweni esifanayo, bonke abahlanganyeli babuye bahlolwa ngezimpawu zokucindezeleka besebenzisa i-Beck Depression Inventory (BDI).
I-BDI iqukethe imibuzo engamashumi amabili nanye yezinqumo ezikhethiwe ezithathwa yilowo nalowo esikalini kusuka ku-zero kuya ku-ezintathu, kanti ezintathu zimelela izimpawu ezinzima kakhulu. Izibonelo zempawu zokucindezeleka ezibuyekezwe kuloluhlolo zifaka:
- imizwa yokudabuka, ukuphelelwa ithemba, ukudumazeka, ukuzwa icala, kanye / noma ukucasula
- izimpawu zomzimba ezifana nokulahlekelwa isisindo, ukukhathala, ukulahlekelwa isithakazelo kwezocansi, nokulahlekelwa ukudla
- imicabango yokuzibulala
Ekupheleni kwesifundo, abahlanganyeli abathatha i-coenzyme Q10 babe nokuthuthuka okuphawulekayo ezimpawu zabo zokucindezeleka, uma kuqhathaniswa nabahlanganyeli abathatha ipilisi ye-placebo.
Okushiwo Imiphumela Yokufunda
Imiphumela iphakamisa ukuthi i-coenzyme Q10 iyasiza ekunciphiseni kokubili ukukhathala kanye nezimpawu zokucindezeleka kwabahlanganyeli abane-MS. Lena umbono othakazelisayo, ikakhulukazi kusukela i-coenzyme Q10 itholakala ngaphezu kwe-counter.
Ibuye iphrofayili yempembelelo ephansi, nemiphumela emibi ejwayelekile ehlanganisa:
- isisu sithukuthele
- isiyaluyalu
- isifo sohudo
- ukushayeka
- ikhanda
I-Coenzyme Q10 nayo iyatholakala eziningana zefomula kubandakanya ama-capsules alula futhi aqinile, amaphilisi, ngisho ne-spray yomlomo.
Konke lokhu kuthiwa, isifundo sasincane (abahlanganyeli abangu-45 nje kuphela) futhi sahlala amasonto angu-12. Izifundo ezinkulu nezinesikhathi eside ezihlola imiphumela ye coenzyme Q10 kubantu abane MS kumele kwenziwe.
Kubalulekile futhi ukuqonda ukuthi iCoenzyme Q10 ayivunyelwe yi-US Food and Drug Administration (FDA) yokuphatha noma yisiphi isimo sezokwelapha, kuhlanganise nokukhathala ku-MS.
Funa Isiqondiso Esivela Kudokotela Wakho
Ngisho noma i-coenzyme Q10 ingeza futhi itholakale ngaphandle kwemithi kadokotela, kufanele ithathwe kuphela ngaphansi kokuqondiswa kukadokotela, ikakhulukazi ngoba kungenzeka ukuthi akulungile wonke umuntu.
Ngokwesibonelo, kwabanye abantu, i-coenzyme Q10 inganciphisa ushukela wegazi. Lokhu kungase kube inkinga kubantu abanesifo sikashukela abaphuza imishanguzo yezinga elincane le-ushukela egazini.
Kungase futhi kuhlanganyele neminye imithi efana nemithi ye-blood pressure noma imithi yokwehlisa igazi. Ngakho-ke ngisho noma udokotela wakho ekunika ukulunga ukuze uzame coenzyme Q10, ungadinga ukuqapha okukhethekile.
Futhi, umthamo osetshenziswe kulesi sifundo uphakeme kakhulu ku-500mg ngosuku. Amabhodlela amaningi amaningi athi angathathi ngaphezu kuka 200mg ngosuku. Uma uzozama lokhu okungeziwe, qinisa umthamo oqondile nodokotela wakho. Isibonelo, ukuthatha umthamo ophansi kakhulu kungaba yindlela yokwelapheka (ngamanye amagama, unganikezeli ithuba lokukusiza).
A Peek In the Future of Coenzyme Q10 in Multiple Sclerosis
I-Coenzyme Q10 ayizange ihlolwe kakhulu ku-multiple sclerosis, kodwa lokhu kungase kuguquke.
Eqinisweni, ucwaningo oluxhaswe yiNational Institute of Neurological Disorders kanye neStroke luhlola imiphumela yomuthi okuthiwa i-Idebenon-izidakamizwa ezenziwe ngabantu ezifana ne-coenzyme Q10. Ucwaningo luhlola ukuphepha nokusebenza kwe-Idebenone ekwelapheni abantu abane -MS ehamba phambili .
Ucwaningo luqhathanisa ngokulinganisa izinga lokuqhubekela phambili kwe-brain atrophy (ukwehla kobuchopho ekulahlekelweni kwamangqamuzana emisipha) kubantu abathatha i-Idebenone ngokumelene nabantu abathatha i-placebo.
Lolu cwaningo luhlolo lwesigaba se-I / II, ngakho-ke kakhulu, kodwa lujabulisayo-ikakhulukazi njengoba okwamanje alukho imithi elamukelwe yi-FDA yokwelapha i-MS ehamba phambili.
Izwi elivela
Ngenkathi uphenyo olwengeziwe lwesayensi luzodingeka lwenziwe ngokuphepha nokuhlomula ukuthatha i-coenzyme Q10 ekuphatheni izimpawu ze-MS njengokukhathala, noma ngisho nesifo ngokwayo, lokhu kufundelwa ngo-2016 kuNuroscience Neuroscience kuyisiqalo esihle.
> Imithombo:
> Mezawa M et al. Ifomu elincishisiwe le-coenzyme Q10 lithuthukisa ukulawulwa kwe-glycemic kweziguli ezine-type 2 yesifo sikashukela: isifundo sokuhlola umshayeli ovulekile. Biofactors . 2012 Nov-Dec; 38 (6): 416-21.
> Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 njengokwelashwa kokukhathala nokucindezeleka ezigulini eziningi ze-sclerosis I-Nutr Neurosci . 2016; 19 (3): 138-43.
> Sanoobar M et al. I-Coenzyme Q10 ukwengezela iqinisa amamaki okuvuvukala kweziguli ezine-sclerosis amaningi: i-blind blind double, i-placebo, elawulwa icala elingakahleleki emtholampilo. I-Nutr Neurosci. 2015 Meyi; 18 (4): 169-76.
> I-University of Maryland Medical Centre. (Januwari 2015). Coenzyme Q10.
> US National Institutes of Health. (Okthoba 2016). I-Blumb Double Blind Placebo-Controlled Phase I / II Trial Clinical of Idebenone ezigulini ezinezimboni ezihamba phambili ezihamba phambili (IPPoMS).