I-Tumor Necrosis Factor ibangela ukuvuvukala
I-tumor necrosis factor (TNF) yinto eyenziwa ngamaseli omzimba wakho omzimba onemiphumela eminingi ekukhuthazeni inqubo yokuvuvukala . Ikhiqizwa ngokuyinhloko yi-macrophages, uhlobo lwe-white cell cell, kodwa lungakhiwa namanye amaseli.
I-Tumor Necrosis Factor ku-Immune Response
I-TNF iyinhlangano engokwemvelo yempendulo yomzimba yomzimba ngama cell tumor, amabhaktheriya, kanye namagciwane.
Idlala ingxenye kokubili ekusebenzeni okunzima nokuvuvukala kwesistimu. Amaseli awakhipha lapho ebona into ethile (i-antigen) ayifinyelele kuyo.
I-TNF iyi- cytokine , iphrotheni yokubonisa. Ama-Cytokines ayimithi yamakhemikhali ehambisa imiyalezo phakathi kwamaseli emzimbeni. Bamba iqhaza ezinhlelweni eziningi eziphilayo, kuhlanganise:
- Ukwanda kweselula
- I-apoptosis, inqubo evamile yokufa kweseli
- Lipid (fat) umzimba
- Ukuhlanganisa, noma ukwakheka kwezindwangu zegazi
I-Tumor Necrosis Factor in Izifo
I-TNF ingase ikhiqizwe ngokweqile noma ngokungalungile ezinkampanini ezahlukene zesifo. Lokhu kungabangela ukuvuvukala okuqhubekayo nezinye izimpawu ezibhubhisayo. Lezi zifo zifaka:
- Izifo ezizenzekelayo ngokuzenzakalela njenge-arthritis ye-rheumatoid
- Ukuphikiswa kwe-insulin
- I-Cancer
I-Tumor Necrosis Factor ne-Rheumatoid Arthritis
I-tumor necrosis i-factor-alpha ingenye ye-cytokines ebaluleke kakhulu ehilelekile ku-arthritis ye-rheumatoid ngokusebenzisa ukungena kwayo ekuphenduleni kokuphendula okuvuthayo.
Ngokujwayelekile, umzimba uvimbela i-TNF ngokweqile ngokwemvelo. Kodwa ngesifo se-rheumatic, ihlala isebenza futhi idala ukuvuvukala okuningi. Izidakamizwa ze-TNF zokuvimbela zakhiwe ukulawula le mpendulo yokuvuvukala.
I-TNF Inhibitor Izidakamizwa
Abantu abanezifo zezempilo ezifana nesifo samathambo , i- psoriatic arthritis , nesifo sikaCrohn singase siphathwe ngezidakamizwa ze-TNF inhibitor.
Lezi zidakamizwa zibophezela ku-tumor necrosis factor-alpha, zenza ukuthi zingasebenzi. Lokhu kuphazamisa umsebenzi wokuvuvukala futhi kuphazamise isimiso sakho somzimba omzimba. Kubantu abane-arthritis ye-rheumatoid, lokhu kunganciphisa umonakalo owodwa. Isidakamizwa sokuqala samukelwa ngo-1998 nokunye okwakhiwe. Basesiklasini sezidakamizwa ze- biologic , eziyimithi eqondisa ama-molecule emasethini omzimba omzimba.
Imithi ye-TNF inhibitor ihlanganisa:
- Enbrel (etanercept)
- I-Remicade (i-infliximab)
- Huma (adalimumab)
- I-Simponi (i-golimumab)
- I-Cimzia (i-certolizumab pegol)
Ukusebenzisa i-TNF Inhibitors
I-TNF blockers ayithathwa ngomlomo. Esikhundleni salokho, kufanele uwajobe ngaphansi kwesikhumba sakho noma emthanjeni wakho, ngokuvamile ethangeni lakho noma esiswini. Ngokusho kwemibiko yesiguli, izinguquko ezimpawu zakho ziqala ukwenzeka emva kokulinganiselwa kokubili noma ezintathu.
Uma udokotela wakho ebeka i-blocker ye-TNF engenaject, uzofundiswa ukuthi ungayilungisa kanjani ukuze ungayi kuhhovisi ledokotela isikhathi ngasinye.
Uma udokotela wakho ebeka i-infliximab noma i-golimumab, kuzodingeka uye esikhungweni se-infusion noma ehhovisi likadokotela kuze kube amahora amathathu ukuze uthole ukwelashwa kwakho. Lezi zidakamizwa azitholakali.
Imiphumela emibi ye-Tumor Necrosis Factor Inhibitors
I-TNF blockers ingabangela imiphumela emibi.
Okuvame kakhulu ukuphendula kwesayithi lomjovo, okuvamise ukuqhuma kwendawo ehambisana nokuzwa okuvuthayo noma ukushaya.
Ingozi ekhuphukile yazo zonke izinhlobo zokutheleleka yiyona nethonya elibaluleke kunazo zonke lezigameko ze-TNF ngoba zivimbela isimiso sakho somzimba omzimba. Qinisekisa ukuthi udokotela wakho uhlolisisa ngesifo sofuba nesifo sofuba ngaphambi kokuqala ukwelashwa.
> Imithombo:
> Ulwazi nge-Tumor Necrosis Factor (TNF) Abavimbela (Kuthengiswa njenge-Remicade, Enbrel, Huma, Cimzia, nase-Simponi). Ukuphathwa kwe-US nokuDrug.
> TNF Inhibitors. I-American College of Rheumatology.
> I-TNF ye-Tumor Necrosis Factor kubantu. Isikhungo Sikazwelonke se-Biotechnology Information.