Indlela impendulo yokucindezeleka ithinta ngayo izimpawu zakho
Kungenzeka ukuthi wazibonela kuqala ubuhlobo phakathi kwe-IBS nokucindezeleka. Lokhu kunokuningi okukwenzayo imizimba yethu isabela ekushintsheni kwangaphakathi noma kwangaphandle. Le mpendulo yokucindezeleka, eyaziwa ngokuthi impendulo yokulwa-noma-indiza, ibonakala ithuthukile ukuze isenze siphendule ezimweni ezisongela ukuphila ngendlela engayenza amathuba okuphila.
Impendulo yokucindezeleka yinkambinkimbi enzima. Kuhilela izinhlelo zethu ze-nervous and endocrine futhi kuvuselela izinguquko ezinhlobonhlobo zomzimba, kuhlanganise nokucindezelwa kwegazi, izinga lokushaya kwenhliziyo, ukuphazamiseka kwemisipha kanye nokusebenza kwamathumbu. Kuyinto izinguquko ekusebenziseni isilonda esihlanganisa ukuphendula kokucindezeleka kanye ne-IBS ndawonye.
I-Brain-Gut Connection
Lapho sibhekene nokucindezeleka okubonakalayo (kwangaphandle noma kwangaphakathi), izingxenye ezehlukene zobuchopho ziqala ukuxhumana, kufaka phakathi i-cortex enenzwa, i-thalamus, nobuchopho. Le nqubo ibangela ukuthi impendulo ihambe ngezindlela ezimbili zomzimba ezinkulu. Owokuqala yi-hypothalamic-pituitary-adrenal axis, okuholela ekukhuleni kwamakhemikhali e-hormone, ikakhulukazi i-hormone cortisol. Indlela yesibili uhlelo lwesimiso sokuzimela , olukhishwa i-adrenaline (i-epinephrine) ne-noradrenaline (i-norepinephrine) eyenza isimo se-cardiovascular, muscular and digestive sishintshe.
Lezi zindlela ezimbili zithinta ngqo inethiwekhi yezinzwa ezitholakala emathunjini, eyaziwa ngokuthi uhlelo lwe-enteric senzwa. Le nqubo, eqala ngokucindezeleka okubonakalayo, elandelwa impendulo yobuchopho, futhi eholela ekuvuseleleni emigwaqeni emibili ukuya emanzini, ibonisa ukubaluleka kokubheka ukucindezeleka kokuzama ukuzama ukuqonda ukungasebenzi okubonakalisa njengezimpawu ze-IBS.
Izinguquko Zomzimba Ekuphenduleni Kokucindezeleka
Ukuphendula ngokucindezeleka kubangela izinguquko ezilandelayo zomzimba:
- Ukushaya kwenhliziyo kwanda
- Ukuphefumula okwandisiwe
- Ukwanda kwe-muscle okwandayo
- Ukuvimbela amasosha omzimba
- Ukudambisa ekuphumeni kwesisu
- Ukwandisa ngesivinini sezinhlangothi zokulala
- Ukuphumula kwemisipha yesinye
Ucwaningo
Emzamweni wokuthola ukwelashwa okuphumelelayo kwezimpawu ze-IBS, abacwaningi bebephenyisisa izinto ezihlukahlukene ezikhishwe ngesikhathi sokucindezeleka. Into eyodwa ebonakala ibaluleke kakhulu ekuphenduleni ukucindezeleka i-corticotropin-release-factor (CRF). I-CRF ngumndeni wama-peptide (ama-molecule ahlanganisa ama-amino acids) atholakalayo kokubili ebuchosheni nasemathunjini. Ebuchosheni, ama-CRF receptors atholakala ezindaweni ezihlobene nokugaya, imizwelo kanye nesistimu yezinzwa ezizimele. Emgodini, isenzo se-CRF ngaphakathi kwekhaloni ukwenzela ukwandisa ukucinwa kwamanzi namanzi, kuthinta ijubane lezinhlangothi zokuqhaqhazela (i- motility ), futhi kubonakala sengathi lihlobene nokuhlangenwe nakho kobuhlungu besisu . Kuthemba ukuthi ukuqonda okungcono indima ye-CRF kuyoholela ekuthuthukiseni imithi eqondisa izimpawu ze-IBS.
Imithombo:
Benson, H. I-Relaxation Response (2000). I-New York: HarperTorch.
Monnikes, H., et.al. "Ukubangela ukucindezeleka ezinkingeni zomzimba ezisebenzayo. Ubufakazi bokushintsha kokucindezeleka ekukhuliseni kwamathumbu kanye nokuzwela." Izifo ezibizwa nge- Digestive Diseases 2001 19: 201-211.
I-Mayer, EA, et.al. "Ukucindezeleka Nendlela Yomzimba" I- American Journal of Physiology- Imizimba Yezinyosi Nezinyosi 2001 4: G519-G524.
I-Tache, Y. "Ukucindezeleka ne-Irritable Bowel Syndrome: Ukususa i-Code" I-International Foundation ye-Functional Disorders Fact Sheet. 2007.