I-Irritable Bowel Syndrome kanye neSistimu Yezinzwa
Ukungasebenzi kahle ekuxhumaneni phakathi kobuchopho nokugulisa kungase kubangele ukugulisa isifo sofuba (IBS).
Ezinye izinkinga zempilo zihle kakhulu ukuziqonda. Uma unomphimbo obuhlungu , udokotela wakho uzothatha isampula lesishubhu emqaleni wakho futhi ahlole ukuhlola ukuthi une-strep infection. Imvukuzane ekhangayo ekhanda lakho ingahlolwa ukuze ubone ukuthi ingumdlavuza.
Ngeshwa, i-IBS ayikude. Ngokungafani nezifo ezibonakalayo, ukuqonda okungahambi kahle ku-IBS, abacwaningi bathole ukuthi badinga ukubuka ngaphesheya kwegulane nakwezinhlelo zokuxhumana eziyinkimbinkimbi ezixhuma emathunjini ebuchosheni.
Ukuze uqonde ngempela umsebenzi owenziwa kule ndawo, kuzodingeka ube nezinga le-neuroscience. Ngisho ngaphandle kwezinga elinjalo, kuyasiza ukuba nokuqonda okuyisisekelo kokuxhumeka okuyinkimbinkimbi phakathi kobuchopho namagundane nokuthi lokhu kuhlobene kanjani ne-IBS.
Biology Basics
Bona ukuthi noma yikuphi kulezi zingxoxo ezilandelayo zithinta insimbi evela esikhathini sakho esichitha esikoleni esiphakeme se-biology esikoleni esiphakeme. Ukuxhumana phakathi kwazo zonke izingxenye zomzimba wethu kwenzeka ngokusebenzisa ukudluliswa kolwazi kusuka emanzini kuya nasiswini. Nansi incazelo elula yemigwaqo ehlukahlukene lapho lokhu kuxhumana kwenzeka khona:
- Isistimu Yezinzwa Eziphakathi (CNS): ubuchopho kanye nentambo yomgogodla
- Isistimu ye-nervipheral ye-peripheral (PNS): imigudu yezinzwa ezidlulela ngaphesheya kobuchopho nomgogodla.
Uhlelo lwesimiso sezinzwa luphinde luhlukaniswe izingxenye ezimbili:
- Isistimu yokwesaba okweSomatic: ephethe ukulawula ngokuzithandela kwemizimba kanye nokusabela ekuzweleni kwangaphandle.
- Isistimu ye-neon autonomic : ephethe izimpendulo zezimoto nezinzwa zezitho zangaphakathi (i- viscera ).
Uhlelo lwe-Inic yeNervous
Uhlelo lwe-enteric lwezinzwa (ENS) luyingxenye yesimiso sezinzwa ezizimele ezibhekene nenqubo yokugaya. I-ENS ilawula i- motility (ukunyakaza kwemisipha), ukufihla kokugeleza kwamanzi nokugeleza kwegazi. I-ENS ilawula umthwalo omkhulu ngokwayo ukuthi ngezinye izikhathi inikezwa igama elithi "ubuchopho obuncane." Ngenxa yalokhu kuchazwa, kulula ukubona ukuthi ukuqonda indlela uhlelo lwe-enteric olusebenza ngayo kubalulekile ekuqondeni ukuthi yini engase ihambe kahle umzimba nge-IBS.
Phezulu ku-Starecase Down
Ukuxhumana yindlela emgwaqeni lapho kufika ebuchosheni (isimiso sezinzwa zomphakathi) kanye nesistimu yokugaya umzimba (isimiso sezinzwa se-enteric). Izindlela eziyinkimbinkimbi zixhumanisa ubuchopho namathumbu ngolwazi olugeleza ngokuphindaphindiwe njalo. Lokhu kuxhumano okuseduze kubonakala ngokucacile ekuphenduleni kwethu ekucindezelekeni (ukusongelwa okubonakalayo), okusikisela ukuthi le nethiwekhi yenethiwekhi eyinkimbinkimbi ibaluleke kakhulu ekusindeni kwethu njengezinhlobo zezilwane.
Abacwaningi bathola ubufakazi bokuthi ukungasebenzi kahle kulezi zindlela ezihamba phambili nezansi kungase kube nomthelela ekuhluphekeni kwesisu , ukuqotshwa kanye / noma isifo sohudo eziyimpawu ze-IBS. Amazinyo emanzini abhekana nokuzwela ngokweqile angabangela ushintsho ebuchosheni.
Imicabango, imizwa, nokuvuselela izingxenye zobuchopho ezihlobene nokukhathazeka noma ukuvusa kungakhuthaza izimpendulo zamanzi ezikhukhumezayo. Ukulimala kungatholakala futhi ezindleleni eziningi ezahlukene ezixhuma ubuchopho nokugwinya. Ngokwesibonelo, kunobunye ubufakazi bokuthi ukusebenza okungavamile ngezindlela ezimbili ezihlukene ohlelweni lwezinzwa ze-autonomic kuhlotshaniswa nesifo sohudo ngokumelene nesifo sokuqothulwa. Ngokuvamile, kubonakala sengathi ukungasebenzi kahle ohlelweni lokuxoxisana kwamagciwane ukuphazamisa ikhono lomzimba lokugcina i-homeostasis, isimo lapho zonke izinhlelo zisebenza kahle.
Umsebenzi We-Serotonin
I-biology engaphezulu: Izindlela lapho isisetshenziswa esisodwa sezinzwa zixhumana khona ngokulandelayo kungukusebenzisa amakhemikhali abizwa ngokuthi ama-neurotransmitters . I-neurotransmitter eyigugu kakhulu yokusebenza kokugaya isisotonin (5-HT). Kulinganiselwa ukuthi amaphesenti angaba ngu-95 we-serotonin emzimbeni womuntu atholakale kumgudu wokugaya. I-Serotonin ibhekwa njengengxenye ebalulekile yohlelo lokuxhumana phakathi kobuchopho kanye namanzi. I-Serotonin ibonakala ibamba iqhaza ku- motility , ukuzwela , nokufihla kwamanzi. Ukuhamba komzwelo, ukuzwela ubuhlungu kanye nomthamo wetshezi esitokisini - ungabona ukuthi kungani i-serotonin ibilokhu igxile kubacwaningi be-IBS.
Ukungafani kuye kwatholakala emazingeni e-serotonin phakathi kweziguli eziphethwe yisifo sohudo kulabo abanokuqothulwa. Iziguli ezinesifo sohudo zazinamazinga aphakeme kunamazinga avamile e-serotonin egazini labo ngemva kokudla, kanti iziguli ezahlukunyezwa zinezinga eliphansi kunezinga elivamile le-serotonin. Lo umehluko uhambisana nemizamo yokuthuthukisa imithi ekhuphuka noma eyanciphisa amazinga e-serotonin ngokukhomba izindawo ezithile zokuthola ( 5-HT3 no-5-HT4) ukuphatha i-IBS. Kukhona imithi emibili enjalo, kodwa kokubili kunemikhawulo eqinile ekusebenziseni kwabo ukuvimbela imiphumela emibi kakhulu emibi:
- I-Lotronex : i-blocker ye-5-HT3 yokwelashwa kwesifo sohudo
- I-Zelnorm: L i-5-HT4 evuselela ukwelashwa
Isiqondiso samuva socwaningo lwe-IBS sigxile ekilasini lama-protini okuthiwa i-serotonin reuptake transporters (SERTs). Ama-SERT anesibopho sokususa i-serotonin ngemuva kokukhishwa. Kunesinye isibonakaliso sokuthi kukhona umehluko kumsebenzi we-SERT uma i-IBS noma ukuvuvukala kukhona. Esinye isikole sokucabanga ukuthi ukudlula kwe-serotonin kuphazamisa inqubo ye-homeostasis, ngaleyo ndlela kuvimbela uhlelo lokugaya ukusebenza ngendlela evamile.
Ulwazi nguMandla
Ungahumusha kanjani ulwazi lwakho olusha ekusizeni ukuphatha kangcono IBS yakho? Ngokusobala, awunawo amandla okuthinta ngokuqondile amazinga wakho we-serotonin. Kodwa-ke, kunezindawo ezimbili lapho izenzo zakho zinomthelela oqondile ohlelweni lokuxhumana phakathi kobuchopho kanye nesisu.
Ngokusebenzisa umzimba wokuzilibazisa , ungasebenzisa ngenkuthalo ukususa impendulo yokucindezeleka, lapho izinguquko zokugaya zivela khona ekuphenduleni imicabango nemizwa. Ungase ucabange nge-reflex ye-gastrocolic lapho iziphazamiso ze- colon zivuselelwa ngokudla ukudla okukhulu noma ukudla okunamafutha uma unquma ukuthi yikuphi ukudla okumele udle. Ukuze uthole isifo sohudo, kungaba ngcono ukudla ukudla okuncane, kuyilapho ekuqothulweni, ukudla okukhulu kungaba kuhle ukunyakaza kokuhamba kwamathumbu.
Ukuqonda ukuthi izinkinga ku-IBS zandisa ngendlela engaphezu kokuba "nesisu" singakusiza ukuba uhlakulele amasu ahlukahlukene okubhekana nalezi zinkinga.
> Imithombo
> Fukudo S. Ukucindezeleka nobuhlungu be-visceral: Ukugxila emzimbeni wesifo sofuba. Ubuhlungu . 2013; 154. i-doi: 10.1016 / j.pain.2013.09.008.
> Meerveld BG-V, uJohnson AC, Grundy D. Imizimba Yezinambuzane, kanye Nomsebenzi. I-Handbook of Pharmacy yokuhlola . 2017. ini: 10.1007 / 164_2016_118.
> Norton, W. & Drossman, D. "Umbiko We-Summary Report" (2007) I- Digestive Health Matters 16: 4 -7.
> Oświęcimska J, Szymlak A, Roczniak W, i-Girczys-Połedniok K, i-Kwiecień J. Okungaqondakali kuma-pathogenesis kanye nokwelashwa kwesifo sofuba esiswini. Ukuthuthuka kwezokwelapha . 2017; 62 (1): 17-30. doi: 10.1016 / j.advms.2016.11.001.