Buza Udokotela Wakho Mayelana Nemiphumela Ebizayo Ngaphambi, Esikhathini, nangemva kokuthatha Le Mithi
I-Mercaptopurine ingumuthi owaziwa ngokuthi ungumphikisi we-purine. Isetshenziselwa izimo zokwelapha ezifana nesifo sikaCrohn nesifo sofuba (izinhlobo ezimbili zesifo sofuba esivuvukalayo [IBD] ) kanye ne-acute lymphocytic leukemia. Kungasetshenziselwa ukwelashwa kwezinye izimo kanye.
I-6-mercaptopurine (i-6-MP) ijwayele ukuthathwa kanye ngosuku, futhi inganikwa noma i-tablet noma umjovo.
Izinto Ezibaluleke Kakhulu Ukukwazi Ngo-6-MP
- I-MP-6 akufanele ithathwe zingakapheli amasonto amabili ukuthola umgomo wokuphila
- Ukunciphisa inani elimhlophe legazi lesisindo kungumphumela ohlangothini olungenzeka
- Udokotela angenza njalo ukuhlolwa kwegazi ukuze aqaphe ukusebenza kwesibindi
- Abesifazane kufanele basebenzise ukulawula ukubeletha ukugwema ukukhulelwa ngenkathi bethatha ama-6-MP
- Ukubeletha ngokuvamile akunconywa ngenkathi kuthatha u-6-MP
Ulwazi olubalulekile mayelana no-6-MP
Izinto ezibaluleke kakhulu zokwazi mayelana no-6-MP ukuthi zingabangela imiphumela eminye yemiphumela, njengokulahlekelwa izinwele, ukuhlanza, isifo sohudo, nokulahleka kokudla. Akufanele futhi isetshenziswe ngaphakathi kwamasonto amabili ukuthola ukugoma okuphilayo. Uma ungaqiniseki ukuthi ukugoma owawutholile kwakuphilile, hlola nodokotela wakho.
Ukulahlekelwa izinwele kungabangela ukucindezeleka okukhulu, kodwa kufanele kuguquke lapho isidakamizwa simisiwe, futhi izinwele zizoqala ukukhula ngokuvamile. Ucwaningo olulodwa lubonise ukuthi abantu abangu-1% abathatha ama-6-MP ukuphatha i-IBD babhekana nokulahlekelwa izinwele.
Okuvamile okwehlisa isisindo segazi esimhlophe , esitholakala ezigulini ezingaba ngu-11%.
Ukukhathazeka okuphuthumayo kunemiphumela emibi njengegazi, ukulimaza, noma izilonda; ukuzondwa noma ukulahlekelwa ulwazi; ubuhlungu bomlomo; kanye nezinhlungu ezihlangene. Ezinye zazo zingase zenzeke njengezibonakaliso ze-IBD, ngakho-ke kubalulekile ukugcina udokotela wakho e-loop kuzo zonke izinkinga ozizwayo.
I-MP-6 ingabangela nokuhlolwa okungavamile kwesibindi, futhi ekutadisheni okukodwa, lokhu kwenzeka cishe ngo-4% weziguli ezithatha ukuphatha i-IBD. Ngenxa yalesi sizathu, udokotela angase afune ukwenza isikhathi sokuhlolwa kwegazi ukuqapha ukusebenza kwesibindi. Kwezinye izimo, izinga eliphakeme lezinto ezithile egazini (aminotransferases) lingase lisho ukuthi umthamo wesidakamizwa udinga ukunciphisa, noma ukuthi udinga ukucinywa.
Kunconywa ukuthi abesifazane basebenzise ukulawulwa kokubeletha ngenkathi bethatha ama-6-MP ukuze bagweme ukukhulelwa. I-MP-6 i-FDA Isigaba sokukhulelwa D: kungase kube izingozi kumntwana, kepha umuthi ungaqhubeka ngoba ukuyeka kungase kube nemiphumela eyingozi kakhulu kumama. Uma ukhulelwa ngenkathi uthatha i-MP-6, tshela udokotela wakho. Ukuncelisa ingane ngenkathi kuthatha ama-6-MP akukhuthazwa.
Imiphumela emibi engavamile ye-6-MP
Hlola nodokotela wakho uma ngabe yimiphi imiphumela emibi elandelayo iqhubeka noma ihlupha:
- ukunyamala kwesikhumba
- isifo sohudo
- ikhanda
- ukulahlekelwa ukudla
- ukukhwabanisa isikhumba nokushaywa
- ubuthakathaka
Njalo Yazisa Udokotela Walezi Imiphumela Ezingezansi
Okuvamile
- ukukhathala okungavamile noma ubuthakathaka
- amehlo aphuzi noma isikhumba
Okuvamile Okuvamile
- ubuhlungu obuhlangene
- ukulahlekelwa ukudla
- isicanucanu nokuhlanza
- ukuvuvukala kwezinyawo noma imilenze ephansi
Akuvamile
- Izilonda emlonyeni nasemilonyeni
Yazisa Udokotela Ngokushesha Ngale Miphumela Emibi
Okungajwayelekile
- amnyama, ama-tarry esitokisini
- igazi emcimbini noma ezitheni
- ukukhwehlela noma ukuphazamiseka
- imfiva noma amahlumela
- ubuhlungu obuphansi emuva noma obuhlangothini
- ukuvuthwa okubuhlungu noma okunzima
- shaya izindawo ezibomvu esikhumbeni
- ukuphapha okungavamile noma ukulimaza
Amanye Amaphuzu Okubalulekile
Ngenxa yokuthi imithi isetshenziswa kanjani emzimbeni, kunethuba lokuthi bangabangela ezinye izinto ezingafuneki izinyanga noma iminyaka ngemuva kokuba umuthi usetshenziswe. Lezi zimo ezibambezelekile zingabandakanya izinhlobo ezithile zomdlavuza okufanele zixoxwe nodokotela.
I-Mercaptopurine ingase iqhubeke nemiphumela emibi ngemva kokuyeka ukwelashwa. Phakathi nale nkathi yesikhathi, hlola nodokotela uma ngabe kukhona eminye imiphumela emibi elandelayo:
- amnyama, ama-tarry esitokisini
- igazi emcimbini noma ezitheni
- ukukhwehlela noma ukuphazamiseka
- imfiva noma amahlumela
- ubuhlungu obuphansi emuva noma obuhlangothini
- ukuvuthwa okubuhlungu noma okunzima
- shaya izindawo ezibomvu esikhumbeni
- ukuphapha okungavamile noma ukulimaza
- amehlo aphuzi noma isikhumba
Ezinye imiphumela emibi engabhalwanga ngenhla zingase zenzeke kwezinye iziguli. Uma ubona noma yimiphi imiphumela, hlola nodokotela wakho. Lolu lwazi luqondiswa kuphela njengeseluleko - njalo uxoxe nodokotela noma wemithi ukuze uthole ulwazi oluphelele mayelana nemithi yokwelashwa.
Umthombo:
I-Glazier KD, i-Palance AL, i- Griffel LH, i-Das KM. "Isimo seminyaka eyishumi esisodwa esisodwa singena-6-mercaptopurine ekwelapheni isifo sofuba esiswini." J Clin Gastroenterol . 2005 Jan; 39: 21-26.
UMahadevan U. "Ukuzala nokukhulelwa esigulini ngesifo sofuba esiswini." Gut . 2006 Aug; 55: 1198-1206.
Shaye OA, Yadegari M, Abreu MT, et al. "I-hepatotoxicity ye-6-mercaptopurine (6-MP) ne-Azathioprine (AZA) kubantu abakhulile be-IBD." Am J Gastroenterol . 2007 Nov; 102: 2488-2494.