I-Dronedarone (i-Multaq) iyisidakamizwa esingavamile esakhiwe ekwelapheni i-fibrillation ye-atrial . Ekufuneni kwabo isidakamizwa esiphephile futhi esisebenzayo salesi simo, izinkampani zokwelapha sekuyisikhathi eside zicabangela i-grail yazo engcwele: isidakamizwa esisebenza kahle njengama- amiodarone , kodwa ngaphandle kobuhlungu obuyingqayizivele. I-Dronedarone yasungulwa nguSanofi (abenzi be-amiodarone) ngokukhethekile ethembeni lokudala lelo grail elingcwele.
Ukuphumelela
Njengoba izidakamizwa eziphikisanayo zihamba, i-dronedarone iyasebenza ngokuphumelelayo ekwelapheni i-fibrillation ye-atrial. Ngeshwa, lokhu akusho okuningi. Izilingo eziningana zemitholampilo ziye zabonisa ukuthi i-dronedarone iphumelela ngokweqile ekugcineni isigqi esivamile kubantu abaye babhekana ne-atrial fibrillation.
Ngokuqondile, i-dronedarone iboniswe ukuthi iphumelela kakhulu kune-placebo. Noma kunjalo, iziguli ezingu-64% eziphathwe nge-dronedarone zaziphindaphindiwe nge-atrial fibrillation phakathi nonyaka wokuqala wokulashwa. Ngokuphambene, iziguli ezingu-75% ezazithola indawo ye-placebo zazivame ukubukeka kwe-atrial fibrillation. Lokhu kuthuthuka okuthobekile kufana nalokho okwakuboniswa nezinye izidakamizwa ezinamandla - futhi, akusho okuningi.
Esilingweni somtholampilo ngokuqhathanisa ukusebenza kwe-dronedarone kuya kwe-amododone, i-dronedarone yaba yinto engaphansi kwesidakamizwa "somzali" wayo. Abantu abangama-64% abane-fibrillation e-atrial ephathwayo ne-dronedarone babephindaphindiwe nge-atrial fibrillation ngonyaka owodwa, uma kuqhathaniswa "no-42% kuphela" kulabo abaphathwa nge-amiodarone.
I-Dronedarone iphikisiwe kanjani?
I-Dronedarone ivela ku-amiodarone, okuyinto ephumelela kunazo zonke, kepha isisindo esiningi esinobuthi, esiyingozi kakhulu esakhiwe. Ngokungafani ne-amiodarone, i-dronedarone ayinayo ama-athomu e-iodine. Kukholelwa ukuthi i-iodine e-amiodarone ikhiqiza ezinye zezidakamizwa ezithinta izidakamizwa eziyingozi, ikakhulukazi ubuthi obuketshezi begazi obubonwe ngesidakamizwa mhlawumbe ne- toxicity yamaphaphu .
Futhi njengoba kuvela, i-dronedarone ayizange ibonise ububanzi obuningi bezinyosi eziyingqayizivele ezihlobene ne-amiodarone. Kodwa-ke, kubikwa ukuthi ubuhlungu besibindi bubikwe nge-dronedarone, kanti ezinye izimo ze-toxicity yamaphaphu nazo zibonwe. Abantu ababenenkinga yesibindi noma yamaphaphu ku-amiodarone akufanele banikwe i-dronedarone.
Ucwaningo luye lwasikisela ukuthi abantu abanokuhluleka kwenhliziyo , noma abashiye izingxenyana ze- ejection ze- ventricular ezingama -35% noma ngezansi, bangase babe nengozi yokufa lapho bethatha i-dronedarone. I-Dronedarone akufanele isetshenziswe kubantu abanezimo.
Eminye imiphumela emibi ye-dronedarone ibonakala iyinhlonipho. Imiphumela emibi kakhulu ebikwe yilezi zihudo noma isicanucanu, izinga lentliziyo elincishisayo, nokushisa.
Okubalulekile
Njengazo zonke izidakamizwa zokulwa, i-dronedarone kufanele isetshenziswe ngokuqapha. Ukusetshenziswa kwalo okunconywe ukusiza ukugcina isigqi senhliziyo evamile ezigulini ezineziqephu ze -fibrillation ye-atrial . Uma i-fibrillation ye-atrial ibuyeka ngesikhathi ithatha i-dronedarone, isidakamizwa kufanele simiswe, futhi isu elihlukile lokwelapha elithathwe.
Isidakamizwa singcono kakhulu esetshenziselwa abantu abasha abanobuchopho obufakwe ngaphakathi kwe-atrial fibrillation futhi abanezinhliziyo ezinempilo enye.
Funda kabanzi mayelana nokuphathwa kwe-fibrillation ye-atrial .
Izwi elivela
Njengoba sekuphelile, i-dronedarone ayiyona igrayili engcwele. Ngempela, indaba nalesi sidakamizwa yindaba efanayo ezwile kaningi ngezidakamizwa eziphikisanayo - ukuthokoza kokuqala, okulandelwa ukudumazeka okukhulu. Njengeqembu, izidakamizwa ezithathelwanayo zisebenza ngokulinganisela kuphela, kodwa ziphakathi kwezidakamizwa ezinobuthi kakhulu emithi. Kufanele isetshenziswe kuphela emva kokucubungisisa ngokucophelela zonke izindlela, futhi uma izinzuzo ezingase zivele zicacile kakhulu kunezingozi zangempela ngempela.
> Imithombo:
> Dorian P. Clinical Pharmacology Of Dronedarone: Imiphumela YeTherapy Of Fibrillation Atrial. J Cardiovasc Pharmacol Ther 2010; 15: 15S.
> Hohnloser SH, Crijns HJGM, van Eickels M, et al. Umphumela we-dronedarone ezimayelana nemisipha ye-fibrillation ye-atrial. N Engl J Med 2009; 360: 668-678.
> Connolly SJ, Camm AJ, Halperin JL, et al. I-Dronedarone e-fibrillation engapheli engozini yokuphefumula. N Engl J Med 2011; I-DOI: 10.1056 / NEJMoa1109867.