Eziningana ze-IBD Imithi ehlose i-TNF Proteins Yokuphatha Ukuvuvukala
I-tumor necrosis factor (TNF) iyinhlobo yeprotheni yesithunywa ebizwa ngokuthi i-cytokine eyenziwa ngamaseli amhlophe egazi . I-TNF ibalulekile emzimbeni ngoba isiza ukulawula ukusabela kwesimiso somzimba sokuzivikela kwamanye amazwe, ikakhulukazi isisu somdlavuza samanje. Ikhuthaza ukuvuvukala, ikhiqiza amanye amaseli asetshenziselwa impendulo yokuvuvukala, futhi ingasiza amangqamuzana aphulukise.
I-TNF ngezinye izikhathi ibizwa ngokuthi i-neorrosis factor-alpha.
Kungani i-TNF-alpha ibalulekile ku-IBD
I-TNF iyisihloko esibalulekile sokuphatha isifo sofuba esiswini (IBD). I-TNF itholakala ngemali ephakeme kubantu abanesifo sikaCrohn kunabantu abangenayo isifo sikaCrohn. I-TNF itholakale, ngezinga eliphansi, esitokisini sabantu abane-ulcerative colitis. Ngenxa yalokhu kubambisana, kucatshangwa ukuthi i-TNF idlala indima ekuthuthukiseni kanye / noma eqhubeka nesifo sikaCrohn kanye nesifo sofuba esiswini. Yingakho izidakamizwa ezibizwa ngokuthi yi-biologics zenzelwe ukuphatha i-IBD nezinye izimo ezivuthayo. Ukubhekela i-TNF kubonisa inzuzo kwezinye iziguli ekunciphiseni izimpawu ze-IBD nasekuphulukiseni ukuvuvukala emaphethelweni emathumbu.
I-calprotectin ye-fecal ne-lactoferrin yizimpawu ezimbili ezisetshenziselwa ukuhlola ukuvuvukala kwamanje kubantu abane-IBD. La maprotheni amabili angalinganiswa ngokuhlola isitokisi.
Kutholakale ukuthi uma kukhona okuningi kulawa maprotheni esitokisini, kukhona ukuvuvukala okuningi emathunjini abantu abane-IBD. Lapho inani lala maprotheni liphansi esitokisini, kube khona ukuphulukiswa okuqhubekayo emathunjini. I-calprotectin ephansi ye-fecal ne-lactoferrin ingasho ukuthi ukwelashwa kusebenza nokuthi isiguli siseduze, noma siphelelwe yisikhathi.
Ucwaningo lubonise ukuthi amazinga e-fecal calprotectin namazinga we-lactoferrin aphansi ezitheni ezithathe izidakamizwa ezilwa ne-TNF.
Izinhlobo ezahlukene ze-TNF
Ucwaningo lwe-Genetic lubonisile ukuthi kunezinhlobo ezahlukene ze-TNF, futhi i-TNF empeleni ibhekwa "yi-superfamily." Izinhlobo ezihlukahlukene ze-TNF ziye zahlotshaniswa nezifo ezithile ezizimele, amagciwane, nesifo sikashukela. Ukuthola izinhlobo ze-TNF-ezihambisana nezimo ezithile kungasiza ekwakheni izidakamizwa ukuphatha lezo zifo.
Akuwona wonke umuntu onayo i-IBD ephendula izidakamizwa ezifanayo ngendlela efanayo. Lokhu kungaba, futhi manje kucatshangwa ukuthi yilokho ochwepheshe, ukuthi kunezinhlobo eziningi ze-IBD. I-TNF ingadlala indima kulokhu futhi, ngoba abanye abantu abane-IBD basabela kahle kakhulu kwizidakamizwa zokuvimbela i-TNF, kuyilapho abanye abantu bengenzi. I-genotype ye-TNF yesiguli esithile ingase ihlotshaniswe nokuphendula okukhulu noma okuncane kumuthi othile othize we-TNF. Lokhu kuyindawo evelayo yokucwaninga, kanti kusekhona okuningi okumele kuqondwe nge-TNF ngaphambi kokuthi kusetshenziswe ekunakekelweni kwesiguli.
TNF-alpha In Cancer Colon
I-TNF ingaba nendima ebalulekile ekwakheni umdlavuza wekoloni nezinye izifo zomdlavuza wesisu. Ucwaningo olwenziwe kulolu hlobo lwe-TNF alukali lutho, kodwa lungase lunikeze nezici ezithile ekuxhumaneni phakathi kwe-ulcerative colitis nomdlavuza we-colon.
Imithi yama-Anti-TNF-alpha
Ezinye zokwelapha ze-Crohn's disease zibandakanya ukukhomba amaprotheni we-TNF nokuzibophezela. Lapho iphrotheni iboshwe kanjalo, ayikwazi ukuveza ukuvuvukala. Ezinye izidakamizwa zokulwa ne-TNF yi- Remicade (infliximab), i- Humira (adalimumab), i- Cimzia (certolizumab pegol), i- Enbrel (etanercept), ne-Simponi (golimumab).
Inothi Kusuka
Kukhona okuningi okungaqondakali mayelana ne-TNF kanye nobuhlobo bayo nezimo ezivuthayo ezifana ne-IBD. Kodwa-ke, izidakamizwa eziningana ze-TNF zenzelwe ukusetshenziswa kubantu abane-IBD, futhi kungenzeka ukuthi zithuthukise imiphumela yenkambo yalezi zifo.
> Imithombo:
> Sipponen T, Savilahti E, Kärkkäinen P, et al. "I-calectectin ye-Fecal, i-lactoferrin, nesifo se-endoscopic ekuqapheleni ukwelashwa kwe-TNF-alpha yesifo se-Crohn." I-Inflamm Bowel Dis. 14: 1392-1398.
> Subramaniam K, uRichardson A, uDodd J, et al. "Ukuqapheliswa kokuqala kwe-colectomy nokugcinwa kwesikhashana kwesikhashana ekukhunjweni kweziguli ezilonda izilonda kuphethwe ngokusebenzisa i-anti-tumor necrosis factor therapy." I-Intern Med J. Meyi 2014; 44: 464-470. i-doi: 10.1111 / imj.12397.
> Taylor KD, Plevy SE, Yang H, et al. "I-ANCA iphethini kanye noLTA nobuhlobo be-haplotype ekuphenduleni kwemitholampilo ekwelashweni kwe-anti-TNF e-Crohn's disease." I-Gastroenterology . 2001 Meyi; 120: 1347-1355.
> Yang JP, Hyun MH, Yoon JM, et al. "Inhlangano phakathi kwe-TNF-α-308 G / A i-polymorphism yesiginja kanye nengozi yomdlavuza wesisu: ukubuyekezwa okuhlelekile nokuhlaziywa kwe-meta." I-cytokine . 2014 Dec; 70: 104-114. doi: 10.1016 / j.cyto.2014.07.005.