Okudingeka Ukwazi Nge-Entyvio (i-Vedolizumab)

Le Mithi Eyasetshenziselwa Ukwelapha IBD ivimbela ukuvuvukala ku-Tract Digestive Tract

Izinto Ezibaluleke Kakhulu Ukuze Ukwazi Nge-Entyvio

Kuyini i-Entyvio?

I-Entyvio (i-vedolizumab) i-gut-homing α4β7 integrin ephikisanayo esebenza ukuphatha izinhlobo ezimbili eziyinhloko zesifo sofuba (IBD) . I-Entyvio isebenza ngokubophezela ku-α4β7 integrin, okuvimbela i-integrin ekungeniseni okuqhubekayo ekuvukeni kwesistimu yokugaya ehambisana ne-IBD. I-Entyvio okwamanje ivunyiwe ukuphatha ngokulingana nesifo esiqinile se-Crohn noma ukulinganisela ekuqotheni kwesifo se-ulcerative. I-Entyvio yasungulwa, futhi idayiswa yi-Takeda Pharmaceuticals.

I-Entyvio ithathwe kanjani?

I-Entyvio inikezwa ukumnika , kungaba ehhovisi likadokotela, esibhedlela, noma esikhungweni sokungenisa ukumnika. Lapho ukwelashwa kuqala, i-Entyvio inikezwa ngamathambo amathathu okuqala: ukumnika kokuqala, okulandelwa enye ukukhishwa kwamasonto amabili kamuva, kanye namasonto amane wesithathu ngemuva kwalokho (isikhathi esiphelele siphezulu amaviki ayisithupha).

Ngemuva kokungcoliswa okwesithathu, i-Entyvio inikezwa cishe onke amasonto angu-8. Ukumnika ngamunye kuthatha cishe isigamu sehora. Udokotela ochaza i-Entyvio uzonikeza noma yiziphi iziyalezo ezikhethekile okumele zilandele ngaphambi nangemva kokugonywa.

Kungani i-Entyvio ihlelwe?

I-Entyvio iyatholakala ukuphatha iziguli ezinomqondo olinganiselwe kuya ezimweni ezinzima zombili izinhlobo eziyinhloko ze-IBD (isifo sikaCrohn nesifo se-ulcerative colitis).

I-Entyvio isetshenziselwa kuphela emva kweminye imithi ye-IBD evivinywe futhi ayisebenzi ukuphatha izimpawu. I-Entyvio ayivunyelwe ukuphatha izingane ezingaphansi kweminyaka engu-18. Uma ukwelashwa kuphumelela, abantu abathatha i-Entyvio bangathola izibonakaliso zabo nezimpawu ze-IBD, futhi bangakwazi ukuthola isikhathi sokuxolelwa .

Ubani Akufanele Athathe Ukungena?

Tshela udokotela wakho uma uke waba nalezi zimo ezilandelayo:

Yimiphi imiphumela engase yenzeke ye-Entyvio?

Ngokusho kolwazi olusuka ku-Takeda Pharmaceuticals, imiphumela emibi kakhulu ye-Entyvio ihlanganisa ukushisa okuvamile (i-nasopharyngitis), ikhanda, izinhlungu ezihlangene, isifo sokukhwabanisa, umkhuhlane, ukuphefumula okuphezulu okuphefumula, ukukhathala, ukukhwehlela, i-bronchitis, umkhuhlane, ubuhlungu be-back, ukuqhuma , ukuhlunga, ukutheleleka kwesinus, ubuhlungu bomphimbo, nobuhlungu emaphethelweni. Tshela udokotela wakho ukuthi ngabe yimiphi imiphumela emibi ihlupha noma ungahambi.

Ngokuvamile, imiphumela emibi nakakhulu ingenzeka, njengokungathi ukugula okungaholela ku-anaphylaxis. Ingozi eyengeziwe yokutheleleka ibuye ikhathazeke, futhi izifo ziye zabikwa ezigulini ezamukele i-Entyvio.

Imiphumela emibi, ikakhulukazi noma yikuphi okungase ikhombise ukusabela okweqile noma ukutheleleka, kumele kubikwe kudokotela okhethwe ngokushesha.

Imiphi Imithi Engayifaka I-Entyvio?

I-Entyvio ingakafundiwe kakhulu ngokusebenzisana kwezidakamizwa. Tshela udokotela wakho uma uthatha i-Tysabri (natalizumab), i-block necrosis factor alpha blocker, i-immunosuppresants, noma i-corticosteroids. Njalo utshele udokotela wakho mayelana nayo yonke imithi kanye nezithako ozithathayo.

Ingabe Kukhona Ukusebenzisana Ukudla?

Akukho ukusebenzisana kokudla okuyaziwayo.

Ingabe i-Entyvio Safe ngesikhathi sokukhulelwa?

I-FDA ihlukanise i-Entyvio njengesidakamizwa sohlobo B.

Umphumela wokuthi i-Entyvio inomntwana ongakazalwa awufundiwe kakhulu. I-Entyvio kufanele isetshenziswe kuphela ngesikhathi sokukhulelwa uma kudingeka ngokucacile. Yazisa udokotela ochazayo uma ukhulelwa ngenkathi uthatha i-Entyvio. Ayaziwa ukuthi i-Entyvio idlula ubisi lwebele. Amandla emibi kakhulu emithonjeni kufanele ahlolwe ngokubaluleka kwemithi kumama. Enye indlela ukuyeka ukuncelisa ngaphambi kokuphatha i-Entyvio.

I-Entyvio Yingakanani Ingasetshenziswa Ngokuphepha?

I-Entyvio ivunyelwe ngo-2014, ngakho-ke akuyona into eyaziwa okwamanje mayelana nokusetshenziswa kwayo kwesikhathi eside. Ukubuyekezwa kokuhlolwa okuyisithupha kwe-Entyvio okwenzeka eminyakeni engaba ngu-4 kubonise ukuthi lesi sidakamizwa sinesiprofetho sokuphepha esihle.

Imithombo:

CCFA.org. "I-Biologic Therapies." I-Crohn's And Colitis Foundation Of America. 6 Feb 2014.

> Colombel JF, Sands BE, Rutgeerts P, et al. "Ukuphepha kwe-vedolizumab ye-ulcerative colitis nesifo sikaCrohn." Gut . Ngo-2017 Meyi; 66: 839-851.

Entyvio.com. "Mayelana ne-Entyvio." Takeda Pharmaceuticals, Inc. 2015.

EntyvioHCP.com. "Indlela Yokusebenza." Takeda Pharmaceuticals, Inc. 2015.