Isizathu Esiphezulu Kwama-Weekly Dose
I-methotrexate isilinganiso se-arthritis ye- rheumatoid nezinye izinhlobo zokuvuvukala kwamathambo kufanele zithathwe masonto onke, hhayi nsuku zonke njengeminye imithi eminingi. Ngoba ngokungafani nesimiso somuthi ojwayelekile, kudideka ekuqaleni, ngaphandle kokuthi udokotela wakho athathe isikhathi sokuchaza kahle.
Amaphutha asetshenziswe iziguli ezazicabanga ukuthi "ngesonto lonke" kwakuyisiphambeko nje sokushicilela kwi-label ye-methotrexate.
Uma ungakabaza, shayela umuthi wemithi yakho bese ushayele udokotela wakho. Hlola kabili noma kathathu-hlola izikhombisi-ndlela uma kunesidingo. Kuyinto ebalulekile ukuyiqonda kahle. Ngokuvamile, i-Institute for Safe Medication Practices ithola imibiko yokudlula ngokweqile komlomo we-methotrexate ngenxa yokungena kwengozi yansuku zonke.
I-Weekly Dose ye-Methotrexate
I-Methotrexate yayiyisidakamizwa somdlavuza ngaphambi kokuba ivunyelwe isifo samathambo. Umthamo osetshenziselwa isifo samathambo kanye nezinye izifo ezivuthayo ziyingcosana uma kuqhathaniswa nalezo ezisetshenziselwa umdlavuza. Ngokuvamile, abantu abane-arthritis ye-rheumatoid ekuqaleni baqokelwe amaphilisi ama-2.5 milligram methotrexate (ama-7,5 milligrams inani) ukuba athathwe kanye kanye ngesonto, ngosuku olufanayo lwesonto (isib. Njalo ngoMgqibelo). Uma kudingeka, udokotela angase akhulise umthamo, kodwa kusathathwa masonto onke, hhayi nsuku zonke.
Ngokwe-rheumatologist uScott J. Zashin, MD, "Ukuthatha methotrexate kanye ngesonto kuhlinzeka ngempumelelo kepha kunciphisa ingozi yomonakalo wesibindi nesomnyo." Kukhona amandla okuba nemiphumela enobuthi obukhulu, ikakhulukazi i-hepatoxicity, uma i-methotrexate ithathwa ngokungalungile nsuku zonke.
Akumelwe neze ukwandise umthamo onqunyiwe we-methotrexate noma ushintshe isimiso sokulinda ngokwakho.
I-Methotrexate Dose ephelele ye-Rheumatoid Arthritis
Umthamo omdala ovamile we-methotrexate we-arthritis ye-rheumatoid, njengoba kushiwo ngenhla, i-7.5 milligram njenge-dose eyodwa yesonto elilodwa. Kungathathwa njengomthamo ohlukanisiwe: 2.5 milligrams ezithathwe ngomlomo njalo ngamahora angu-12 ngezikhathi ezi-3 kanye ngesonto (isib. 00:00, 12:00, no-23:59 ngosuku olufanayo).
Isilinganiso esivamile samasonto onke omuntu wamasonto omdala we-methotrexate yomlomo ingama-milligram angu-20. Umthamo wezingane ojwayelekile womlomo we-methotrexate we-arthritis ye-rheumatoid ingama-milligram angu-5 kuya kwangu-15 kanye ngesonto.
Ngokusho kwemiphumela yokucwaninga eyashicilelwe ku- Annal of the Rheumatic Diseases , umthamo "obulungile" obususelwa ebufakazini kanye nokuphakanyiswa komuntu abadala abane-arthritis ye-rheumatoid kuhilela isamba sokuqala sama-milligrams methotrexate ngomlomo esithathwe kanye ngesonto. Leli dose lingakhuliswa ngama-milligram ama-5 ngenyanga kuya ku-25-30 milligrams ngesonto noma i-dose ebekezeleleke kakhulu. I-switch to methotrexate engenayo ingenziwa ngabantu abane-arthritis ye-rheumatoid abafinyelela impendulo enganele nge-methotrexate yomlomo noma kulabo abakwazi ukubekezelela ukubunjwa ngomlomo. Kungakhathaliseki ukuthi kwenziwa yiphi izinguquko, kufanele ihlale njengedaysi yesonto.
Ezinye izixwayiso zeMethotrexate
I-Methotrexate ihlotshaniswa nokwanda kokweqile uma kuthathwe neminye imithi, njengezidakamizwa ezingavimba ukuvuvukala (ama-NSAID) , imithi ye-reflux ye-acid, kanye nemithi elwa namagciwane. Ukusebenzisana okunjalo kwezidakamizwa kungabangela ubuthi obuyingozi, futhi mhlawumbe ngisho nokufa. Qinisekisa ukuthi udokotela wakho unolwazi oluphelele lwawo wonke imithi oyithathayo futhi uxoxe ngokusebenzisana okungenzeka nge-methotrexate.
I-Methotrexate akufanele ithathwe ngabantu abanezifo zesibindi, isifo esibalulekile sezinso, ukuphuza utshwala, ukuphazamiseka kwegazi (isb., I- anemia , i-leukopenia) noma i-bone marrow disorder. I-methotrexate akufanele futhi isetshenziswe abesifazane abakhulelwe noma abancancisayo. Kumele futhi kumiswe abesifazane nabesilisa abahlela ukukhulelwa.
Uma uthola izibonakaliso zokuphendula okweqile ngenkathi uthatha methotrexate, funa ukunakekelwa kwezokwelapha eziphuthumayo. Izimpawu ezinjalo zizofaka imihlathi, ukusabela kwesikhumba, ukuphefumula kanzima, ukuvuvukala kobuso, izindebe, ulimi, noma umphimbo. Kufanele ushiye umthamo we-methotrexate bese ufonela udokotela wakho uma uhlakulela ukukhwehlela owomile, ukuphefumula, ukuhuda, ukuhlanza, ama-white patches noma izilonda emlonyeni wakho , igazi emcimbini noma esitokisini, ukutholakala kwesisindo esisheshayo, ukunciphisa umchamo wokukhiqiza umgogodla, ukuthunjwa, umkhuhlane, izimpawu zomkhuhlane, ubuthakathaka, ikhanda elikhanyayo, noma yiluphi olunye uphawu olungavamile.
Imiphumela emibi ejwayelekile ehlobene ne-methotrexate yi-nausea, ikhanda, isizungu, ukukhathala, nombono ongenayo. Abanye abantu abahlangabezana nemiphumela emibi ejwayelekile nge-methotrexate yomlomo bangathola i-methotrexate engenayo ebekezeleleke kakhulu.
Izwi elivela
I-Methotrexate ingaba imithi ephephile futhi ephumelelayo yesifo se-rheumatoid uma sithathwe kahle. Kumele kuthathwe ngokusho kwezinkombandlela, ngaphandle kokuphambuka kulezo zikhombisi-ndlela. Ungalokothi uthathe okungaphezu kwalokho okushiwo futhi ungashintshi isimiso samasonto onke. Qaphela imiphumela emibi engaba khona, ikakhulukazi izenzakalo ezimbi kakhulu, futhi azise udokotela wakho ngokushesha uma kukhona okukhathazayo okuqhubekayo.
Kuzodingeka ukuthi ube nezivivinyo zama-laboratory ngezikhathi ezithile ukuqapha ukubala kwe-cell cell, ama-enzyme yesibindi , nokusebenza kwezinso . Ungaphuzi utshwala ngenkathi uthatha methotrexate. Vumela udokotela wakho wazi uma uhlakulela ukutheleleka okusebenzayo. Buza udokotela wakho mayelana nokuthatha ama-antibiotics ngokutheleleka. Kubalulekile futhi ukuxoxa ngemigomo nodokotela wakho. Abantu abathatha amanani aphezulu we-methotrexate kufanele bagweme imigomo ebukhoma. Ngezansi-ukusetshenziswa okuphephile kwe-methotrexate, kufanele ulandele izinkomba ngokuqinile futhi uqaphele izixwayiso nezinyathelo zokuqapha. Khuluma ngokukhululekile nodokotela wakho nganoma yini ehlala ingacacile, noma noma yini ephathelene nawe.
> Imithombo:
> Ngisho ne-Methotrexate engezansi ephansi ingabangela ukulimala noma ukufa uma kuthathwa nsuku zonke noma ngeminye imithi. UmthengiMedSafety.org. Novemba 30, 2015.
> Methotrexate. Drugs.com. Ibuyekezwe ngo-Agasti 4, 2015.
> Visser K. et al. Isilinganiso esiphelele noMzila Wokuphatha we-Methotrexate ku-Rheumatoid Arthritis: Ukubuyekezwa Okuhlelekile Kwezincwadi. Ama-Annal of the Rheumatic Diseases. Julayi 2009.