I-Otrexup I-Autoinjector Yodwa-I-Auto -jector Ehlukile
I-Otrexup ( methotrexate ) i-autoinjector ene-dose-single-dose ene-dosetrexate. I-Otrexup yavunywa kuqala yi-US FDA ngo-Okthoba 11, 2013. I-Otrexup, eyenziwe ngu-Anatares Pharma, Inc. iyindlela ehlukile kumlomo we-methotrexate, i-vial-and-syringe injectable methotrexate, noma enye i- autoinjector ye- single-dose, i- Rasuvo .
Izinkomba ze-Otrexup
I-Otrexup, i-inhibitor ye-analog ye-analog, i-FDA-evunyelwe ukuphathwa kwabantu abane- arthritis esebenzayo, esebenzayo ye- rheumatoid arthritis ne- polyarticular ye-idiopathic arthritis eyayinempendulo enganele ngokwelapha lokuqala. I-Otrexup nayo yavunyelwa ukulawula izimpawu ezihambisana nokukhubaza, ukukhubaza i-psoriasis kubantu abadala abaye basabela ngokungafanele kwezinye izimo. I-Otrexup ayivunyelwe ukwelashwa kwezifo ze-neoplastic.
Ukuphathwa kwe-Otrexup
Ukuqala ama-methotrexate ama-7.5 mg kanye ngesonto kubantu abane-arthritis ye-rheumatoid, 10 mg / m2 kanye ngesonto ngeziguli ezine-arthritis ye-polyarticular ye-idiopathic arthritis, kanye no-10 kuya ku-25 mg kanye neviki nge-psoriasis. I-Otrexup ilawulwa njengenjovo eyodwa, ngesonto elilodwa. Ingafakwa egangeni noma kumathumbu ngezinkombandlela.
I-Otrexup iyatholakala kuma-dose phakathi kuka-10 kuya ku-25 mg ku-5 mg increments.
Olunye uhlobo lwe-methotrexate, ngaphandle kwe-Otrexup, kufanele lisetshenziswe ezigulini ezidinga umlomo womlomo, u-intramuscular, intravenous, intra-arterial, noma intrathecal, ulinganisa ngaphansi kuka-10 mg ngesonto, amanani angaphezulu kwama-25 mg ngesonto, imirhamo ephezulu , noma ukulungiswa kwamazinga okungenani okungaphansi kuka-5 mg.
Ukungafani
Otrexup akufanele isetshenziswe ngabesifazane abakhulelwe, omama abahlengikazi, noma labo abanezifo zesibindi noma utshwala. Futhi, i-Otrexup kufanele igwenywe ngabantu abane-immunodeficiency syndromes, izifo zegazi ezandulela ngaphambili, noma i-hypersensitivity eyaziwa yi-methotrexate.
Ukusabela Okubi Okuvamile
I-Otrexup ihlotshaniswa nokuphendula okubi okuvamile, kufaka phakathi: i-nausea, ubuhlungu besisu, i-dyspepsia, ukuvuvukala komlomo, izilonda emlonyeni, ukugqwala, i-nasopharyngitis, isifo sohudo, isibindi sokusebenza okungavamile, ukuhlanza, ikhanda lokukhwabanisa, i-bronchitis, inani leplatelet elincane, inombolo encane yegazi elimhlophe amangqamuzana, ukuntuleka kwazo zonke izinhlobo zamaseli egazi, isizungu, izithombe ze-photosensitivity, ne-alopecia.
Uma uhlangabezana nesenzakalo esibi noma ukusabela okubi, ungawabika ku-FDA ku-http: //www.fda.gov/medwatch/ noma ngokubiza u-1-800-FDA-1088. Futhi ungaxhumana nomenzi we-Otrexup ku-http: //www.otrexup.com noma ngokubiza u-1-855-Otrexup (1-855-687-3987).
Ukusebenzisana kwezidakamizwa
Ukuthatha i- aspirin , i- NSAID , noma i- corticosteroids nge-Otrexup ingase ilandise amazinga we-serum methotrexate okwenza ukwanda kokweqile. Ukuthatha i- proton pump inhibitors ngenkathi usebenzisa i-Otrexup kungase kwandise futhi kwandise amazinga we-serum methotrexate, okwandisa ingozi yobuthi.
Qinisekisa ukuthi udokotela wakho unolwazi lwamanje lwawo wonke imithi kanye nezithako ozithathayo. Kungumqondo omuhle wokusebenzisa ikhemisi elilodwa, uma kungenzeka, yonke imithi yakho yesidakamizwa. Kulula ukulandelela ukusebenzisana kwezidakamizwa okungenzeka ukuthi uma izidakamizwa zakho zikhona ohlelweni lwekhomphyutha oyikhethayo.
Ukuxwayiswa nokuqapha
Kukhona isixwayiso esimnyama esikhishwe i-Otrexup esho ukuthi ukusabela okujulile nokufa nokubikwa kuye kwabikwa ngokusetshenziswa kwe-methotrexate. Iziguli ezisebenzisa lesi sidakamizwa kufanele zihlolwe ngenxa yomnkantsha wesibindi, isibindi, umphuphu, isikhumba, kanye nezinyosi zezinso. I-Methotrexate nayo ibike ukuthi ibangele ukufelwa komntwana noma ukungazalwa komzimba okungesizathu sokuphikisana nokukhulelwa.
Ukucindezeleka komnumongo osanda kungalindelekile, ukuphazamiseka kwesifo se-anemia nesifo sobumathunzi kuye kwabikwa ezigulini ezithatha ama-NSAID ngenkathi zisebenzisa i-methotrexate. Ubuthi obunobuthi, i-fibrosis, ne-cirrhosis kungenzeka ngemuva kokusetshenziswa kwesikhathi eside kwe-methotrexate. I-pneumonitis yangaphakathi ingenzeka nganoma yisiphi isikhathi ngisho nangesilinganiso esincane se-methotrexate. Isifo sohudo, stomatitis ulcerative, ukungena kwesisu, kanye ne-intestinal perforation. Okukhulu, okungenzeka kuyingozi, ukusabela isikhumba kungenzeka. Kungenzeka ukuthi izifo ezithathelanayo ezibulalayo zingakhula.
I-non-Hodgkins lymphoma nezinye izicubu ziye zabikwa ezigulini eziphathwe nge-methotrexate ephansi. Kumele kuqashelwe ukuthi ezimweni lapho i-lymphoma eyingozi iqhutshwa khona ngenkathi ukwelashwa nge methotrexate, ukuyeka methotrexate kwakwanele ukudala ukuguqulwa kwe-lymphoma.
I-Methotrexate nayo ibike ukuthi ibangele ukungabi nabantwana kwezinye iziguli, izibalo ezincane zezidakamizwa nokungasebenzi komzimba. Lokhu kungaba inkinga ngenkathi i-methotrexate isetshenziselwa futhi isikhathi esithile ngemuva kokumiswa.
Izwi elivela
Abantu abasebenzisa i-Otrexup kumele babe nokuhlolwa kwegazi ngezikhathi ezithile kuhlanganise nokubala okuphelele kwegazi, ama-enzyme yesibindi, nokuhlolwa kwemisebenzi yezinso. Uma kucatshangwa izinkinga ze-pulmonary, ukuhlolwa kwe-x-ray ne-pulmonary function kungadingeka.
Abantu abasebenzisa i-Otrexup kumele babe nokuqwashisa ngemiphumela engaba yingozi, ukuze bakwazi ukubona futhi babike izindaba ngokushesha nje lapho zenzeka. Kuyavunywa, uhlu lwezenzakalo ezingase zibe nzima kakhulu, kodwa khumbula, abantu abaningi basebenzisa methotrexate ngaphandle kokubhekana nezinkinga. Ukuqwashisa nokuqapha kubalulekile.
Imithombo:
Otrexup. Ulwazi lokuPhelela okugcwele . Kubuyekezwe 3/2016.
Umlando Wokuvuma Otrexup. Drugs.com.