I-Neulasta (i-pegfilgrastim) ingumuthi ngezinye izikhathi osetshenziselwa ukwelashwa kwemithi yesifo somdlavuza webele webele ukuze ukwandise izibalo zegazi elimhlophe ukuze kuncishiswe ingozi yezifo. Yini okudingeka ukwazi mayelana nalesi sidakamizwa, kuhlanganise nemiphumela emibi engenzeka?
I-Neulasta (Pegfilgrastim) Sibutsetelo
I-Neulasta (i-pegfilgrastim) iyisidakamizwa esinikezwa abantu abane-noma abalindeleke ukuthuthukisa i -neutropenia eyenziwa yi-chemotherapy (isibalo esincane se- neutrophil , uhlobo olulodwa lweseli elimhlophe legazi) ngesikhathi somdlavuza we-breastotherapy chemotherapy.
I-Neulasta iyinhlangano yokwenziwa kwe-granulocyte colony-stimulating factor (G-CSF), isakhi eshukumisa ukukhiqizwa kwamangqamuzana amhlophe egazi emnothweni wethambo. Liyi-liquid ecacile evame ukunikezwa njengesibhamu lapho inaliti ifakwa khona ngaphansi kwesikhumba.
I-Neulasta yisidakamizwa esisebenza isikhathi eside esivame ukudingwa kanye kuphela ngokulandela ukukhipha kwamakhemikhali, ngokungafani neNeupogen (filgrastim), okunikezwa nsuku zonke izinsuku eziningana ngomjovo.
Sebenzisa i-Cancer Breast
I-Chemotherapy yomdlavuza webele isithinta wonke amangqamuzana ahlukanisa ngokushesha emzimbeni wakho, kufaka phakathi amaseli omnyo we-bone, okwenza amangqamuzana egazi amhlophe, amangqamuzana egazi abomvu namaplatelet. Ukunciphisa umthambo wamathambo ngesikhathi samakhemikhali kungabangela ukuphazamiseka kwegazi (isibalo esincane esibomvu segazi), i-neutropenia (isibalo esincane se-neutrophil) ne-thrombocytopenia (isibalo esiphansi seplatelet).
Ukubalwa kwe-neutrophil ephansi (ngezinye izikhathi nje ebizwa ngokuthi i-white white cell count count) ingaba yingozi ngoba ingabangela abantu ukuba bathole i-chemotherapy ezifweni.
Umgomo wokusebenzisa i-Neulasta ukusiza ukuvimbela lezi zifo.
Indlela I-Neulasta Esebenza ngayo
Ngokuvamile, umzimba wakho ukhiqiza amaprotheni okukhuthaza ukukhiqizwa kwe-neutrophils. Phakathi ne-chemotherapy, ukukhiqizwa komzimba wakho kwe-neutrophils kuphazanyiswa, i-Neulasta isebenza ukukhuthaza ukukhiqizwa kwe-neutrophils, nokuvuthwa nokuvuselela i-neutrophils esivele ikhona.
Yeka ukuthi i-Neulasta inikezwa kanjani
Uzothola umjovo weNeulasta cishe amahora angu-24 emva kokukhipha kwamakhemikhali. Kungase kunganikwe ngokushesha ngoba kungase kungasebenzi kahle. Ngokungafani neNeupogen, okumele inikezwe ngokuphindaphindiwe kuze kube yilapho inani lakho le-neutrophil liba khona, i-Neulasta inikezwa kanye kanye kuphela ngomjikelezo we-chemotherapy wezinyanga ezimbili noma ezintathu. Ungaba nalo mjovo engxenyeni yakho engaphezulu, isisu, ithanga, noma izintambo.
Ezinye ze-oncologists zineziguli ezizinikeza umjovo wazo ngosuku olulandela i-chemotherapy, futhi okutholakala ngokuzenzakalela "ngomjovo womzimba" nakho kuyatholakala. Ezinye ze-oncologists zincoma ukuthi unayo umjovo emtholampilo wakho noma nodokotela wakho wokunakekela oyinhloko uma kwenzeka ukwelashwa okwenziwe umuthi kumuthi.
Ezinye izindlela eziya ku-Neulasta
Njengoba kuphawuliwe ekuqaleni, enye indlela eya kuNeulasta (pegfilgristim) yi-Neuopogen (filgristim). Ngezinye izikhathi i-oncologist izobuza ukuthi imiphi imithi oyithandayo. Nakuba izidakamizwa zisebenza ngendlela efanayo, kunezinto ezihlukile phakathi kweNeulasta neNeupogen , kufaka phakathi imvamisa yezijovo, ukubekezela, kanye nezindleko.
Ezinye Imiphumela Ejwayelekile
Omunye wemiphumela emibi kakhulu evela ku-Neulasta iyindlela yokwelapha, kanti futhi, yilesi sizathu ukuthi ezinye ze-oncologists zikhetha ukuthi udutshulwe kwenziwe emtholampilo.
Uma uzibeka izibhamu zakho ekhaya, kufanele uzijwayele izimpawu zendlela okungenzeka ukuthi uyasabela ngayo noma i-anaphylaxis.
Umkhuhlane ungase uvele, futhi kubalulekile kudokotela wakho ukuthi anqume ukuthi ngabe umkhuhlane wakho ungenxa yomjovo wakho, noma kunalokho ukutheleleka okuhlobene nokubala kwakho kwegazi elimhlophe eliphansi.
Cishe ingxenye yesithathu yabantu abahlinzekwa nge-Neulasta injection kusho uhlobo oluthile lwezinhlungu zethambo. Ucwaningo lwangaphambili lwathola ukuthi i-Naprosyn / Aleve (naproxen) yehlise ubuhlungu bobabili namathambo nokuphazamiseka kokulala (cishe ngenxa yobuhlungu bezinthambo). Muva nje kwatholakala ukuthi i-antihistamine Claritin (i-loratidine) yombili yanciphisa ingozi yemiphumela emibi futhi yabangela abantu abambalwa abayeka imithi kunelabo abaphathwa nge-Aleve / Naprosyn (naproxen).
Uma uphawula ubuhlungu be-bone, khuluma nodokotela wakho mayelana nokuthi imithi ayincoma ukuthi uyisebenzise. Ukugeza ebhodini elifudumele nakho kungasiza ngezinhlungu zamathambo ezivela e-Neulasta.
Shayela Udokotela Wakho Uma Unayo Lezi Izimpawu
Imiphumela emibi engavamile kanye nokusabela okubi kungase kwenzeke, futhi kubalulekile ukushayela i-oncologist yakho uma unayo izimpawu ezikukhathazayo. Lokhu kubaluleke nakakhulu uma uqaphela:
- Ukukhathala okungavamile nokuzithemba
- Ubuhlungu besifuba
- I-palpitations yenhliziyo
Izimpawu Eziphuthumayo Zifake
Kufanele ushayele udokotela wakho ngokushesha, kodwa funa ukunakekelwa okusheshayo (shayela 911) uma ubona noma yiziphi izimpawu ezibonisa ukusabela kwe-anaphylactic (ukusabela okukhulu kwe-allergen) njenge:
- I-Hives
- Ukuphefumula okunzima
- Ukuvuvukala kobuso bakho, izindebe, ulimi, noma umphimbo
- Ukuqhuma okusabalalisa umzimba wakho
- Ubuhlungu besisu, ikakhulukazi ubuhlungu kwesisu sakho esingaphezulu kwesokunxele
- Ubuhlungu obukhulu behlombe
Izingozi ezingenzeka zokusebenzisa i-Neulasta
I-Neulasta iyisidakamizwa esiphephile kakhulu esetshenziselwa izinhlobo eziningi ze-neutropenia, futhi iningi lesikhathi, imiphumela emibi noma ingozi yemithi igxile engozini yokubalwa kwe-neutrophil ephansi. Ukusabela okubi okungavamile (kodwa ngezinye izikhathi kwenzeka) kufaka:
- Ukuphendula okukhulu kwe-allergenic.
- Isifo sokucindezeleka sabantu abadala (ARDS) .
- Inkinga yesifo segciwane kubantu abane-antenia ye-sickle cell.
- Ukuphuka kwe-splenic .
- Kungenzeka ukugqugquzela ukukhula kwe-tumor (lokhu kungenzeka ukuthi kungenzeka futhi akubonwanga, njengoba i-Neulasta iyisici sokukhula)
Ubani Okufanele Agweme Le Mithi?
Ungathathi lesi sidakamizwa uma:
- Ukhulelwe noma uncelisa
- Unesifo esiya ku-Neulasta
- Uthola okweqile kumikhiqizo eyenziwe usebenzisa ama-bacterium E. coli
Izincomo Ngesikhathi Ukwelashwa
Ngaphambi kokujola kwakho kokuqala kwe-Neulasta, udokotela wakho uzoyala i-CBCs (ukuphelelwa kwegazi okuphelele) ukubona amazinga amapleletletthi akho namaseli egazi abomvu namhlophe, ngokucophelela inani eliphelele lama-neutrophils egazini lakho. Njengoba ukwelashwa kuqhubekela phambili, uzoba nokuhlolwa okuningi kwegazi ukuhlola ukusebenza kwe-Neulasta.
Uma unakekela noma ukhulelwe, khuluma lokhu nodokotela wakho ngaphambi kokuthatha i-Neulasta. Kubekho izifundo ezanele ezenzelwe ukunquma umphumela walesi sidakamizwa ngobisi lwebele noma isisu somuntu.
Ukunciphisa Ingozi Yakho Yezifo Ngesikhathi Chemotherapy
Ngisho noma uthola izijovo ze-Neulasta ukuphakamisa isibalo sakho segazi elimhlophe, kungenzeka usengozini yokuthola isifo ngesikhathi se-chemotherapy. Ngezinye izikhathi amangqamuzana egazi amhlophe, ngisho noma ayenele, awasebenzi kahle. Ngisho nangokusebenzisa i-Neulasta, ungase ube nezikhathi emva kokukhipha ukukhipha kwakho uma isibalo sakho segazi elimhlophe siwela ngezansi kwamazinga lapho kungenzeka khona ukutheleleka. Thatha isikhashana ukuthi ufunde ngalokho ongakwenza ukuze unciphise ingozi yokutheleleka ngesikhathi se-chemotherapy . Ukusikisela: ezinye zalezi zinyathelo aziwa kahle futhi zingase zikumangaze.
> Imithombo:
> Aapro, M., Boccia, R., Leonard, R. et al. Ukuhlanza Umsebenzi We-Pegfilgrasti (i-G-CSF Edelelekayo) Yokuvimbela I-Chemotherapy-Ekhishwa Ngama-Neutropenia: Izincomo Zemihlahlandlela Yokubambisana. Ukondla Ukusekela Ekhanda . 2017. 25 (11): 3295-3304.
> Botteri, E., Krendyukov, A., noG. Curigliano. Ukuqhathanisa i-Granulocyte Colony-Inctimating Factor Filgrastim ne-Pegfilgrastim kwaBoosimilars kwiMigomo Yokusebenza Ne-Safey: Ukuhlaziywa Kwe-Meta-Ukuhlaziywa Kwezinkinga Zomtholampilo Ezingenakulinganiswa Ngama-Cancer Abalandeli. I-European Journal of Cancer . 2018. 89: 49-55.
> Kirshner, J., McDonald, M., Kruter, F. et al. I-NOLAN: I-Randomised, Isigaba sesi-2 Yokuhlola Ukulinganisa Umphumela We-Prophylactic Naproxen noma i-Loratidine no-No Prophylactic Treatment on Bone Pain in Iziguli ezine-Stage Can Stage Cancer Ukuthola I-Chemotherapy ne-Pegfilgrastim. Ukondla Ukusekela Ekhanda . 2018. 26 (4): 1323-1334.