I-oncologist yakho kungenzeka ukuthi yakhuthaza izijovo ze-Neupogen uma une-chemotherapy yomdlavuza webele. Iyini injongo yale mijovo, yenziwa kanjani, futhi yimiphi imiphumela emibi ongase uyenze?
Sibutsetelo
I-Neupogen (i-filgrastim) iyisidakamizwa esinikezwa abantu abathola i-chemotherapy abanesisindo esiphansi se-neutrophil (i-neutrophil eyakhiwe yi-chemotherapy .) I-neutrophils uhlobo lwe-white cell cell elisiza ukuvimbela ukutheleleka.
I-Neupogen isebenza ngokugqugquzela umnyoba wethambo ukwandisa ukukhiqizwa kwamangqamuzana egazi elimhlophe.Isikhamera esicacile esivame ukunikezwa njengesibhamu (umjovo.)
I-Neupogen inganikezwa ngokweqile emva kwe-chemotherapy okungenzeka ukuthi inciphise kakhulu inani lakho le-neutrophil (njenge-dose kabili i-Cytoxan ne-Adriamycin.) Ngezinye izikhathi kunganikezwa uma ukuhlolwa kwegazi kwakho kubonisa ukuthi isibalo sakho segazi elimhlophe, ngokuqondile inani lakho le-neutrophil eliphelele, liphansi ngokwanele ukukubeka engozini enkulu yokuthuthukisa isifo.
I-Neupogen kubantu abane-Cancer Breast
I-Chemotherapy yomdlavuza webele ihlasela wonke amangqamuzana ahlukanisa ngokushesha emzimbeni wakho, kuhlanganise namaseli emnothweni wamathambo okwenza amangqamuzana egazi amhlophe, amangqamuzana egazi abomvu namaplatelet. Lapho wonke lawa maseli wegazi ehliswa, kubizwa ngokuthi ukuxoshwa komnkantsha wekhambo kusuka kumakhemikhali.
Ngenkathi abantu bangase bahlakulele izinga elincane lamaseli abomvu (i- chemotherapy-induced anemia ) kanye namaplatelet (thrombocytopenia eyenziwa yi-chemotherapy) ngokuvamile izinga eliphansi le-neutrophils (i-neutrophils eyenziwa ngamakhemikhali) eyenza ingozi enkulu.
Phakathi ne-chemotherapy, i-oncologist yakho izohlola i-CBC yakho kaningi.
Indlela i-Neupogen isebenza ngayo
Ngokuvamile, umzimba wakho ukhiqiza amaprotheni okukhuthaza ukukhiqizwa kwe- neutrophils enqubo ebizwa nge- hematopoiesis . Kodwa ngesikhathi se-chemo ngomdlavuza wesifuba, umzimba wakho ungase ungenzi ngokwanele le phrotheni. I-CBC yakho ingabonisa ukuthi izibalo zakho zegazi le-neutrophil ziphansi nokuthi unesi-neutropenic.
Imijovo ye-Neupogen izoqinisa ukukhiqizwa kwe-neutrophils yakho. Ungase uzizwe u-aches nobuhlungu besifo ngenkathi le mithi isebenza, kodwa kungasiza ukucabanga ukuthi amasosha omzimba wakho awakhiwe futhi aqina ngokwengeziwe ekuvikeleni impilo yakho.
Ukuphatha
Uzoba nemisipha ye-Neupogen kanye nsuku zonke kuze kube yilapho iseli lakho elimhlophe libala ukuthi libuyela emazingeni ajwayelekile. Lapho kunikezwa kahle, lezi zijovo ngeke zilimaze. Lesi sidakamizwa singabuye sinikezwe nge-infusion emangalisa (IV).
Okuqhamuka uma udla imishanguzo
Akuwona wonke umuntu ozoba nemiphumela emibi ku-Neupogen, kodwa kokubili ubuhlungu bezinthambo nomkhuhlane zivamile. Ubuhlungu buvame ukuzizwa njengempuphu ejulile ezifundeni zomzimba wakho lapho iningi lamaseli akho egazi lenziwa khona, njengethambo lakho lesifuba, imilenze yakho engenhla, kanye nekhanda lakho.
Ngokujwayelekile, ukwelashwa akudingekile ubuhlungu besifu kodwa khuluma nodokotela wakho kusengaphambili. Angase ancome ukuthi uthathe iTylenol (i-acetaminophen) noma u-Advil (ibuprofen) kodwa, njengoba imithi ingakwazi ukuhlanganyela noma ibeke izinkinga uma isibindi sakho noma izinso zingasebenzi kahle, kubalulekile ukusula lokhu kusengaphambili. Abantu abaningi bathola ukuthi ukugeza emanzini okufudumala kusiza ekunciphiseni ubuhlungu obukhulu emathambo.
Kufanele Ubize Dokotela Wakho Nini?
Ngezinye izikhathi kungase kwenzeke ukuphendula futhi kufanele ushayele udokotela wakho ngokushesha uma kufanele uthuthuke:
- Ukusabela okweqile (izimpungushe; ukuphefumula kwezinkinga; ukuvuvukala kobuso, izindebe, ulimi noma umphimbo; ukuqhuma okusabalalisa umzimba wakho)
- Ubuhlungu besisu
- Ubuhlungu behlombe
Kumele ushayele udokotela wakho uma ubhala ubuhlungu obuhlungu esifubeni, izinhliziyo zenhliziyo, noma ukukhathala okungavamile noma ukukhathala.
Izingozi
I-Neupogen yisidakamizwa ephephile kakhulu esetshenziselwa izinhlobo eziningi ze-neutropenia. Ngokuvamile akunazifo ezimbi noma ezihlala njalo kulo muthi. Noma yimiphi imiphumela emibi ozoyibona izosusa futhi iphele lapho umisa ukuthola ama-shou Neupogen. Kube khona amacala okuphuka kwamapeni okuholela ekufeni, nakuba lokhu kungavamile kakhulu.
Ubani Okufanele Agweme Le Mithi?
Ungathathi lesi sidakamizwa uma:
- Ukhulelwe noma uncelisa
- Unesifo esibuhlungu ku-Neupogen
Izincomo
Ngaphambi kokujova kwakho kokuqala kwe-Neupogen, udokotela wakho uzoyala i-CBCs evamile ukuthi athole ama- platelets akho, amangqamuzana egazi abomvu namhlophe, nama-neutrophils. Njengoba ukwelashwa kuqhubekela phambili, qhubeka nokuhlolwa kwegazi okulandelwayo okulandelwayo. Lokhu kubalulekile njengoba behlola ukuphumelela kwe-Neupogen nokuthi uthola isilinganiso esifanele.
Uma unakekela noma ukhulelwe, khuluma lokhu nodokotela wakho ngaphambi kokuthatha i-Neupogen. Kubekho izifundo ezanele ezenzelwe ukunquma umphumela walesi sidakamizwa ngobisi lwebele noma isisu somuntu.
Okubalulekile
I-Neupogen (noma i-Neulasta ) ingasebenza kakhulu ekwandiseni izinga le-neutrophils emzimbeni wakho ukunciphisa ingozi yokutheleleka. Kumanje kubalulekile ukuthi uqaphele futhi usebenzise izinyathelo ezinganciphisa ingozi yakho yokutheleleka phakathi kwe-chemotherapy njengokugeza izandla ngokucophelela nokugwema ukuthintana nalabo abagulayo.
> Imithombo:
> Lee, K., Kim, J., Lee, M. et al. Isifundo Esingahleliwe, Esixubileyo, Isigaba II / III Ukunquma I-Optimal Dose nokuhlola Ukusebenza Nokuphepha kwe-Pegteograstim kwi-Chemotherapy-I-Neutropenia Ebonakalayo Uma kuqhathaniswa ne-Pegfilgrastim e-Breast Cancer Patients: KCSG PC10-09. Ukondla Ukusekela Ekhanda . 2016. 24: 1709-1717.