Izinzuzo kanye Nezinkinga Zokwelashwa Okubili Ezivame Ukusetshenziswa
I-Chemotherapy ingabangela ukuthi i-white cell cell yakho ibhale phansi, okubeka engozini yokutheleleka. I-Neutropenia (izinga eliphansi lenye yezinhlobo zamangqamuzana egazi elimhlophe) liphathwa nge-Neulasta noma ne-Neupogen, kodwa yini umehluko, futhi udokotela wakho ukhetha kanjani phakathi kwabo?
Umehluko Phakathi Neulasta Neupogen
I-Neulasta ne- Neupogen zombili zenziwe ngeprotheyini yemvelo eyaziwa njenge-granulocyte -colony stimulating factor (noma "G-CSF").
I-Pegfilgrastim (Neulasta) ine-polyethylene glycol, "i-PEG," iyunithi eyongezwe kuyo, eyenza i-molecule ikhule kakhulu ukuze ihlale ohlelweni lwakho isikhathi eside kunokuthi i-filgrastim (Neupogen).
Zingaki Izilonda Nge Chemo Cycle Ngidinga?
I-Neulasta inikezwa kanye ngomjikelezo ngamunye we-high-dose chemotherapy, okungenani amahora angu-24 ngemuva kokukhipha imithi yamakhemikhali, futhi kungakapheli izinsuku ezingu-14 ngaphambi kokukhipha okulandelayo. I-Neupogen inikezwa ngemijovo eminingana nsukuzonke kuze kube yizibalo zakho ze-neutrophil ezibuyela emazingeni ajwayelekile. Ungadinga nje izibhamu ezintathu noma ezine ze-Neupogen, noma eziningi ezingu-10, kuye ngokuthi isistimu yakho isabela kanjani emthini.
Ukusebenza kanye nemiphumela emibi
Ezilingo zomtholampilo, zombili izidakamizwa ziqhathaniswa kahle ngokuphathelene nalokhu:
- Ukuphumelela ekwenzeni ukukhiqizwa kwe-neutrophil
- Ukubekezelela iziguli
- Ukuphepha kokusetshenziswa
Ngenkathi kokubili imithi iphumelela kakhulu, isifundo se-2015 sathola ukuthi i-neutropenia eqinile (isibalo esincane kakhulu se-neutrophil) sasihle kakhulu kubantu abaphathwa nge-Neulasta ngesikhathi semithi yesifo somdlavuza webele.
Labo abathola i-Neulasta nabo babengenakudinga amathuba okunciphisa imithi yabo ye-chemotherapy noma ukubambezeleka phakathi kwe-infusions.
Imiphumela emibi iyafana. Ubuhlungu be-Bone buwumphumela ovame kakhulu ohlangothini lwazo zombili izidakamizwa, okuhlangene ngamaphesenti angu-31 kuya kuma-26 amaphesenti abantu aseNeulasta namaphesenti angu-24 aseNeupogen.
Labo abahlukunyezwa kakhulu ngamathambo ngezinye izikhathi bangakhetha i-Neupogen phezu kwe-Neulasta ngenxa yalesi sizathu (nakuba kuyingozi kakhulu ukusebenzisa).
Izindleko Nge-Injection Ye-Neulasta ne-Neupogen
I-Neulasta ibiza kakhulu kune-Neupogen, kodwa inani lamanani we-Neupogen elidingekayo linganciphisa umehluko phakathi kwezindleko zale mithi. Kubalulekile futhi ukukhumbula engqondweni izindleko zokwelashwa ngenxa ye-neutropenia ejulile (kanye nengozi elandelwayo yezifo) ezivame kakhulu kulabo abathola i-Neupogen.
- Umjovo owodwa we-6 mg we-Neulasta uzobiza phakathi kuka-$ 5,000 kuya ku-$ 7000, kuye ngokuthi umphakeli.
- Umjovo we-300 microgram we-Neupogen uzobiza phakathi kuka-$ 300 kuya ku-$ 350.
- Umjovo owodwa we-6 mg we-Neulasta izindleko ezifana ne-10.4 300 microgram injection ye-Neupogen.
- U-Amgen unikeza uhlelo lokuqala lwe-FIRST STEP ukunciphisa izindleko zokukhokha ngokuhlanganyela zale mithi kulabo abanomshwalense wezempilo wangasese.
Ingabe Umshuwalense Uyovala Izindleko?
Akuyona yonke inqubo yomshuwalense wezempilo ohlinzeka ngezidakamizwa zemithi ekhokhwayo izothola izindleko ze-Neulasta. Ngaphambi kokuba uqale i-chemotherapy, cela i-oncologist yakho uma udinga i-Neupogen noma i-Neulasta. Ungase uceliwe ukuthi usayine ifomu elikuphoqelela ukuba uhlanganise izindleko zale mithi uma umshuwalense wakho engakhokheli.
Uma ungazi ukuthi umshuwalense wakho uhlanganisa i-Neupogen noma i-Neulasta, fonela inkampani ngaphambi kokuba uqale i-chemotherapy ukuze uthole inqubomgomo yabo yokuhlanganisa. Bangase basize ngezindleko ze-Neupogen, kodwa hhayi i-Neulasta. Usengathola ukwelashwa, kodwa kungenzeka ukuthi unamathele nge-Neupogen (ukujova okwengeziwe) uma umshuwalense wakho ungawufihli i-Neulasta. Uma i-oncologist yakho izwa ngokuqinile ukuthi imithi eyodwa ingase isebenze kangcono kunomunye ongahlanganisiwe, ingase izimisele ukusebenza nekhampani yakho yomshuwalense ukuhlela ukuthunyelwa. Kubalulekile ukuba ummeli wakho siqu ekunakekeleni umdlavuza wakho . Buza imibuzo, ubuze futhi uma kudingeka.
Ngezinye izikhathi ummeli wesiguli angakusiza ukuxazulula ubunzima uma kufanele kuphakame.
Lesi Sinqumo Senziwe Kanjani?
Isinqumo sokusebenzisa i-Neulasta noma i-Neupogen iqhutshwa yisidingo sezokwelapha. Lezi zidakamizwa azigcini nje ngokuthi "icing on the cake" noma into encane eyengeziwe; uma une-neutropenia, kufanele uphathwe ngayo. Buza udokotela wakho ukuthi akusize ekumele akumele uma inkampani yakho yomshuwalense engavumelani ukumboza noma imuphi umuthi oyidingayo.
I-Weekly Chemotherapy ne-Neupogen
Uma unamasonto amancane, i-chemotherapy ephansi, uNeulasta ayiyona inketho. Njengoba i-Neulasta kufanele inikwe amahora angu-24 ngemva kwe-chemo nezinsuku ezingu-14 ngaphambi komjikelezo olandelayo, ngeke usebenze nge-infusions yamasonto onke. I-Neupogen izosebenza kahle nge-chemo yamasonto onke ngoba yenza isistimu yakho isheshe ngokushesha futhi inganikezwa kaningi njengoba uyidinga phakathi kwemijikelezo ye-chemo.
Londoloza kwizindleko zokuphatha, ze-Copayments, nezokuThutha
Uma unayo i-chemo yamasonto onke futhi udinga ukudubula kwe-Neupogen njalo, ungagcina ngezindlela eziningana. Buza umhlengikazi wakho uma ungathatha ama-Neupogen shots ekhaya, futhi uma kunjalo, ubaqeqeshe noma ilungu lomndeni ngendlela efanele yokunikeza umjovo.
Qinisekisa ukuthi ulandela ngokucophelela imiyalo yokugcina, ukulungiselela, nokujova. Lokhu kuzokugcina izindleko zokuphatha, kanye nama-copayments kokuvakasha kwehhovisi ngalinye, nezindleko zokuhamba ezihlobene nokudubula ngakunye. Uzodingeka uvakashele umtholampilo wakho ku-CBC evamile, ukuhlola ukubala kwegazi lakho, ukunakekelwa okukhethekile emazingeni akho we- neutrophil .
Ukuvimbela Izifo
Kubalulekile ukukhumbula ukuthi, noma ngabe uthola i-Neulasta noma i-Neuopogen, kungenzeka usengozini enkulu yokutheleleka. I-Chemotherapy inganciphisa kakhulu inani lamaseli amhlophe egazini lakho (umgomo wokusebenzisa lezi zidakamizwa), kodwa amaseli egazi amhlophe akhona angeke asebenze kanye namaseli ajwayelekile amhlophe egazi. Ukufunda ukuthi unganciphisa kanjani ingozi yokutheleleka ngesikhathi se-chemotherapy kubalulekile njengoba abantu abaningi bengazi ezinye zezinto ezilula abangayenza ukuze banciphise amathuba abo.
Ngezansi ku-Neulasta noma i-Neupogen
kokubili i-Neulasta ne-Neupogen ingakwazi ukunciphisa kalula ingozi yokutheleleka ngesikhathi se-chemotherapy, futhi lezi zidakamizwa manje zivumela abantu ukuba bathole umthamo ophezulu (futhi osebenza kahle) wale mithi kunalokho ngaphambili. Kunemibono embalwa, kuhlanganise nesilinganiso esiphakeme se-neutropenia enamandla ne-Neupogen (okungenani kubantu abanomdlavuza wesifuba) kanye nesifo esikhulu somzimba we-Neulasta.
> Imithombo:
> Brett Hauber, A., Mange, B., Price, M. et al. Izinketho Zokuphatha ze-Pegfilgrastim Prophylaxis: Izintandokazi Zeziguli Nezokwelapha Ezivela Esikhathini Sokuhlolwa Kwesiphambano. Ukondla Ukusekela Ekhanda . 2018. 26 (1): 251-260.
> Kourlaba, G., Dimopoulos, M., Pectasides, D. et al. Ukuqhathaniswa kwe-Filgrastim ne-Pegfilgrastim Ukuvimbela i-Neutropenia nokugcina i-Dose Ukuqina kwe-Adjuvant Chemotherapy kuziguli ezine-Cancer Breast. Ukondla Ukusekela Ekhanda . 2015. 23 (7): 2045-51.