Izitatimende zivame ukusetshenziselwa ukwelapha amazinga aphakeme e- LDL ama-cholesterol . Zinciphisa ukukhiqizwa kwe-cholesterol esibindi ngokuvimbela isici emgwaqweni we-mevalonate. Umphumela omubi wesimiso sokuthi unamathuba okubangela ukulimala kwesibindi. Umphumela omuhle wukuthi banganciphisa ingozi yomuntu yokuthuthukisa umdlavuza wekoloni .
Izibonelo zezitatimende
Izibonelo zama-statins zihlanganisa i-Lipitor (atorvastatin), i-Lescol (i-fluvastatin), i-Mevacor (i-lovastatin), iPravachol (pravastatin), i-Crestor (i-rosuvastatin), ne-Zocor (i-simvastatin).
I-Statins ingazivimbela kanjani ukukhula komdlavuza?
Izitatimende zinemiphumela eminingana emzimbeni. Ziyi-pro-apoptotic, isekela inqubo yokuphula amangqamuzana, kufaka phakathi amaseli omzimba. Ziyi-anti-angiogenic, ezenza ukuvimbela ukwelapha ekuthuthukiseni igazi. Ngaphandle kwegazi, izicubu azikwazi ukukhula nokuhlasela ezinye izicubu. Ziyakhuthaza amangqamuzana e-tumor kumsebenzi wecala lombulali (NK). Lokhu kuzothuthukisa umzimba wakho womzimba ekuhlaseleni nasekubulaleni izicubu ngokuziqaphela njengamaseli angaphandle angafanele avunyelwe ukuqhubeka ekhula emzimbeni. Zonke lezo zibonakala zifana nezici ezingaba nomthelela emathunjini nasekansini ngokujwayelekile. Umbuzo wukuthi ngabe kukhona yini ubufakazi obukholisayo bokuthi ama-statins empeleni anomthelela ekuvikeleni umdlavuza ukukhula futhi usakaze emzimbeni wakho.
Ucwaningo olusiza lesi sicelo
Ucwaningo lwase-Israel lwathola ukuthi ukusebenzisa ama-statins iminyaka engaphezu kwemihlanu kunganciphisa ingozi yokuthuthukisa umdlavuza wamakoloni cishe ngama-50%.
Lesi sifundo sasihlanganisa abantu abangaphezu kuka-3 000, cishe ingxenye yabo ababenomdlavuza wekoloni. Lokho kubonakala sengathi kubhekwa okubalulekile.
Ucwaningo lwaseCanada lwathola ukuthi ukusetshenziswa kwama-statins kunciphisa kakhulu ingozi yokuthuthukisa umdlavuza wekoloni. Kodwa, abalobi bathi abantu abangaba ngu-4,814 bazodinga ukuphathwa nge-statins iminyaka emihlanu ukuvimbela icala elilodwa lomdlavuza we-colon.
Lona inani elikhulu kakhulu lemithi eyenziwa ngamathemba okuvimbela inani elincane kuphela lamacala angempela omdlavuza.
Ucwaningo olungasisekeli lesi sicelo
Ucwaningo lwaseMelika luhlolisisa ubudlelwane phakathi kwezidakamizwa ezinciphisa i-cholesterol kanye nesifo somdlavuza wekoloni kubantu abangaphezu kuka-130 000. Abacwaningi bathola ukuthi izidakamizwa ezinciphisa i-cholesterol, ngokuvamile, aziphazamisi ingozi yomdlavuza we-colon. Baqaphele ngokucacile ukuthi lolu cwaningo alusekeli umbono wokuthi izitembu, njengeklasi yezidakamizwa, zinciphisa kakhulu ingozi yokuba nomdlavuza wekoloni noma i-rectum.
Kodwa-ke, njengoba lolu cwaningo aluzange luhlole izinhlobo ezithile zezimiso zesimiso, akunakuqeda ukuthi kungenzeka ukuthi izinhlobo ezithile kanye nokulinganisa kwezitho zomzimba kunganciphisa ingozi yomuntu yokuthuthukisa umdlavuza wekoloni.
Ukubuyekezwa kokuhlolwa kuka-2015 kuphelile, "akukaqinisekiswa ukuthi izitembu zithonya ingozi yokuthuthukisa umdlavuza we-colorectal, umdlavuza webele, noma umdlavuza wamaphaphu."
Ngaphansi
Ingabe ama-statins anciphisa ingozi yomuntu yokuthuthukisa umdlavuza wekoloni noma cha? Ngeshwa, ijaji lisalowo mbuzo. Okwamanje, kuzodingeka silungiselele "mhlawumbe" futhi sigcine iso ukuze uthole olunye ucwaningo. Umbuzo ungase uvezwe ngenye indlela esikhathini esizayo.
Imithombo:
Stryjkowska-Góra A, Karczmarek-Borowska B, Góra T, Krawczak K. "Izitatimende namanqamu." Qaphela i-Oncol (i-Pozn) . 2015; 19 (3): 167-75. doi: 10.5114 / wo.2014.44294. Epub 2014 Aug 29.
U-Hillmer, uM. NoJuurlink, D. "Ingabe Amadayimenti Ayanciphisa Ingozi YeCrorectal Cancer?" I-Canadian Medical Association Journal 173.7 (Septhemba 2005). 1 Septhemba 2006.
UJamess, E. noRodriguez, C. " Izitatimende ze-Static and Colorectal Cancer in the US " Journal of the National Cancer Institute 98.1 (Jan. 2006): 69-72. 20 Jan. 2006.
Whitworth, Ariel. "I- Cholesterol-Ukunciphisa Izidakamizwa Akuhlangene Nengozi Yokunciphisa Ngomdlavuza Wegazi. " Journal of the National Cancer Institute 98.1 (Jan. 2006): 1. 20 Jan. 2006.