Lezi zimpawu zingase zifike kahle ngaphambi kwezimpawu 'zakudala'
Odokotela basebenzisa izibonakaliso zemoto zakudala zesifo sikaParkinson - ukuhamba kancane ( bradykinesia ), ukuphumula ukuzamazama nokuqina - ukuthola ukuthi izimpawu zesiguli zihambisana nokuxilongwa kukaParkinson.
Kodwa abanye abacwaningi manje banamathemba emaqenjini amasha wezimpawu - okuthiwa "izimpawu zangaphambi kwezimoto" ezingaphambi kwezibonakaliso ezintathu zeParkinson eminyakeni eminingana.
Ucwaningo luye lwabonisa ukuthi inqubo yokulahleka kwe-dopamine iqhubekile okungenani iminyaka emihlanu ngaphambi kokuthuthukiswa kwezimpawu zamagciwane e- Parkinson's disease , ngakho-ke kungenzeka ukuthi ube nezimpawu zakudala ezihlobene nalesi sifo.
Yiqiniso, eziningi zalezi zibonakaliso zangaphambi kwezimoto azizona eziqondile, futhi zivamile kubantu abangenawo ama-Parkinson. Ngakho-ke, akuwona wonke umuntu owenza i-Parkinson ibonise lezi zimpawu zangaphambi kwezimoto, futhi akuwona wonke umuntu ohlangabezana nalezi zimpawu oqhubeka nokuthuthukisa i-Parkinson.
Yiziphi Izimpawu Zokuqala Zama-Parkinson?
Yini ebhekwa njengezibonakaliso zangaphambi kwezimoto zikaParkinson? Odokotela abakazange babambe phansi uhlu oluphelele, kepha ngokuvamile lezi zimpawu zibhekwa njengezifakiwe:
- Ukungasebenzi Okubalulekile - Nakuba ubunzima bokunuka bungase bubonakale njengenkinga encane kakhulu, empeleni kubaluleke kakhulu. Cishe 60% kuya ku-100% weziguli zika-Parkinson ezisezibonakaliso zemoto zinezinkinga ezingasebenzi. Eqinisweni, isifundo esisodwa sithole lesi sibonakaliso kwakuyisici esilungile kunazo zonke umuntu angakha i-Parkinson. Ucwaningo olunzulu lomtholampilo lubonise ukuthi abantu abanezinhlelo eziphansi zokusebenza babenezinyathelo ezi-5.2 ezinyuka ekuthuthukiseni i-Parkinson, futhi iphunga elinokukhubazeka lingalandela izimpawu zemoto okungenani iminyaka emine.
- Ukuqotshwa - Ukuqokwa sekuyisikhathi eside kuhlotshaniswa nezimpawu zeParkinson. Kodwa kubonakala sengathi ukuqothulwa kwangempela kungase kube uphawu lwe-pre-motor yalesi sifo. Ucwaningo olulodwa lwabonisa ukuthi abantu abaye babhekana nokuqotshwa phakathi nempilo babenengozini emine yokuthuthukisa kamuva uPilinson ekuphileni.
- REM Sleep Behavior Disorder (RBD) - Abantu abanalesi sifo badlala amaphupho abo ngenkathi belele ngokuziqamba, ukubamba, ukukhahlela nokushaya. Imisebenzi yabo yephupho ivame ukuhlukumezeka futhi ingalimala noma isiguli noma umlingani wombhede wombhede. Le disorder yiyona ehamba phambili kunazo zonke zokuhamba phambili kwe-Parkinson. Izifundo zibonise ukulungiswa okuphawulekayo, kufaka phakathi okubonisa ukuthi abantu abangu-45% abane-RBD basebenzile i-Parkinson noma i- Lewy emzimbeni wokugula komzimba ngemva kweminyaka engu-11 nengxenye kamuva.
- Ukucindezeleka - Lesi yisibonakaliso esingaqondakali sokufaka eqenjini langaphambili, njengoba kungekho ubufakazi obuqinile obuxhumanisa i-depresson ku-Parkinson. Kodwa-ke, izifundo ezibukeka umlando weziguli zikaParkinson zivame ukwanda kwephesenti lalabo bantu abanokucindezeleka uma kuqhathaniswa nezilawuli. Kusho ukuthini lokhu? Kusho ukuthi abantu abaneParkinson cishe banomlando wokucindezeleka uma kuqhathaniswa nomphakathi jikelele. Kodwa-ke, iziguli eziningi ezinokucindezeleka aziqhubeki ukuthuthukisa uParkinson.
Izimpawu zangaphambi kweMoto zingandisa ukuqonda
Kungani kubalulekile ukwazi ngezibonakaliso zangaphambi kwezimoto zesifo sikaParkinson? Yebo, kunezizathu eziningana.
Okokuqala, ukuqaphela lokhu kubonakaliswa kokuqala kukaParkinson kwandisa ukuqonda kwethu kwenkinga yesifo, kanye nenqubo ebangela.
Futhi nakuba kungekho izindlela zokwelapha ezizokwelapha uPalinsinson okwamanje, umuntu angacacisa ukuthi uma lezi zakhi zikhula, zingase zisetshenziselwe ukwelapha lesi sifo ezinyangeni zayo zokuqala - ngaphambi kokuba izimpawu zemoto ziqale.
Imithombo:
Hickey, MG, BM Demaerschalk, noRJ Caselli. "Ukunyakaza kwe-Idiopathic Rapid-eye-REM (Sleep) I-Sleep Behavior Disorder Ihlangene Nokuthuthukiswa Kwekusasa Kwezifo Ze-Neurodegenerative." I-neurologist 13.2 (2007): 98-101. Iwebhu.
Olanow, CW, F. Stocchi, no-Anthony E. Lang. "I-Emerging Entity of Pre-Motor-Parkinson's Disease." Izifo zikaPasinson: Izici ezingezona ezimoto nezingezona ezenziwe nge-dopaminergic . Chichester, West Sussex, UK: Wiley-Blackwell, 2011. 93-104. Phrinta.
URoss, uG. Webster, uHelen Petrovitch, uRobert D. Abbott, uCaroline M. Tanner, uJordan Popper, uKamal Masaki, uLenore Launer noLon R. White. "Inhlangano Yokungasebenzi Ngokwemvelo Okubangelwa Ingozi Yezifo Ezizayo ZasePasinson." Ama- Annal of Neurology 63.2 (2008): 167-73. Phrinta.