Ukusetshenziswa okuphephile kwe-colchicine kunciphisa imiphumela engavumelekile
I-Colchicine iyinqubo yokwelashwa ye-arthritis e-gouty. Nakuba umuthi kuyindlela ephawulekayo yokwelashwa kwe- gout , kuningi okungavamile ngokuziwa nge-colchicine. Isibonelo, ukuthi i-colchicine isebenza kanjani, kusukela lapho itholakala khona, ingakanani isikhathi esinezinhloso zokwelapha, futhi okubaluleke kakhulu, okudingayo ukwazi ukusebenzisa lesi sidakamizwa ngokuphepha.
Imininingwane ebalulekile mayelana ne-Colchicine ye-Gout
1.
I-Colchicine iyi-alkaloid etholakala emhlabathini owomile we-Colchicum autumnale, owaziwa nangokuthi i-crocus noma i-saffron ekwindla.
Ukusetshenziswa kwe-alkalid colchicum ekwelapheni i-gout ephawulekayo kubuya ngo-1810. Ukubaluleka kokwelapha kwa-colchicum kwabikwa emuva ekhulwini lokuqala AD Colchicine isetshenziselwe ukuphatha izimo ngaphandle kwe-gout, kubandakanya:
- Ama-Amyloidosis
- Isifo sikaBehcet
- I-Dermatitis herpetiformis
- Imfiva ejwayelekile yaseMedithera
- Isifo sikaPaget
- I-Pericarditis
- I-Pseudogout
- I-biliary ne-hepatic cirrhosis
2. I-Colchicine iyatholakala emithweni yomlomo noma engaphakathi.
I-Colchicine iyatholakala ngamandla amabili womlomo - amaphilisi angu-0.5 mg no-0.6 mg. Lesi sidakamizwa sitholakale ngaphakathi kwangaphakathi, kepha kukhona okungenzeka kube nobuthi obukhulu ngokusebenzisa umzila wesibindi (okusho, ukungena emzimbeni noma umjovo, umzila ngaphandle komgwaqo wokugaya).
3. I-Colchicine inezakhiwo eziphikisayo, kodwa ukusetshenziswa kwayo ngezinhlobo zobuhlungu ngaphandle kwe-gout kunqunyelwe.
Nakuba i-colchicine ithathwa njengempumelelo kakhulu ekwelapheni i-arthritis enamandla, ayiphumeli kuzo zonke izinhlobo zobuhlungu. I-Colchicine ayithathwa njengesidakamizwa se- analgesic (ie, i-painkiller). Aphinde ayithinte isinqumo se-uric acid .
4. I-Colchicine isebenza ngendlela ehlukile kunezinye izidakamizwa ezidabukisayo noma izidakamizwa eziphikisayo.
I-Colchicine ibophezela kuma-protein kuma-microtubules we-neutrophils. Ama-neutrophils ayilungu legazi elimhlophe . Ngokubopha i-neutrophils, amaseli akakwazi ukuthuthela endaweni yokuphendula okuvuthayo ku-uric acid crystal deposits. I-Colchicine inomphumela wokucindezela osiza ukunciphisa ukuhlaselwa kwe-gout acute, ngaleyo ndlela kukhulule ubuhlungu nokungahambi kahle okuhlobene ne-gout.
5. I-Colchicine iphinde inconywe ukuthi isebenzise njalo phakathi kokuhlaselwa njengesilinganiso se-prophylactic futhi ingase isebenze ekuvimbeleni ukuhlaselwa uma kuthathwe isibonakaliso sokuqala sokungakhululeki.
I-dose evamile yokunciphisa ukuhlasela kwe-gout i-1 kuya ku-1.2 mg (amabili 0.5 mg noma amaphilisi amabili 0.6 mg). Leli dose lingalandelwa yiyunithi eyodwa yamathebhulethi wamandla njalo ngehora, noma amayunithi amabili njalo emahoreni amabili kuze kube yilapho ubuhlungu bukhululeka. Ngemuva kwesilinganiso sokuqala, ngezinye izikhathi kuyanele ukuthatha u-0.5 noma 0.6 mg njalo amahora amabili noma amathathu. Isidakamizwa kufanele simiswe uma kunomkhuhlane wamathumbu noma isifo sohudo.
6. I-Colchicine ingasetshenziswa ngokuqhubekayo njengokwelashwa okuvimbelayo.
Ezigulini ezine-gout attack one ngonyaka, umthamo ovamile u-0.5 noma u-0.6 mg ngosuku, izinsuku ezintathu noma ezine ngesonto. Kulabo abanokuhlaselwa okungaphezu kokukodwa ngonyaka, umthamo ovamile u-0.5 noma u-0.6 mg nsuku zonke.
Amacala amakhulu angadinga amaphilisi amabili noma amathathu ama-0.5 noma amaphilisi angu-0.6 mg nsuku zonke.
Ukusabela okubi kungenziwa nge-colchicine ukusetshenziswa futhi kubalulekile ukuba uqaphele lokho okusemandleni.
Ukucindezeleka komnumongo we- Bone , ne-anemia ye-aplastic, ne-agranulocytosis, noma nge-thrombocytopenia kungenzeka ngeziguli ezithola ukwelashwa isikhathi eside.
Okunye ukusabela okungalungile okungabonakala kuhlanganisa:
- I-neuritis ye-Peripheral
- I-Purpura
- I-Myopathy
- Ukulahlekelwa izinwele
- I-azoospermia ephendukelekayo (ukungabikho okuphelele kwesidoda)
Ukuvuthwa, isifo sohudo, kanye nesisulu sokudla kukhona nemiphumela emibi engase ivele nge-colchicine therapy, ikakhulukazi lapho ukulinganisa okuphezulu kunqunywe khona.
8. Abesifazane abakhulelwe kumele balinganise izingozi nezinzuzo zokusetshenziswa kwe-colchicine.
I-Colchicine kufanele isetshenziswe ngesikhathi sokukhulelwa kuphela uma inzuzo engaba khona iqinisekisa ukuthi ingane engaba khona engozini. I-Colchicine ingabamba ukuhlukaniswa kweseli, ngakho kungaba yingozi enkulu ukuthatha lesi sidakamizwa ngenkathi ekhulelwe. Ukuqapha kufanele futhi kusetshenziswe uma i-colchicine isetshenziswa owesifazane onakekelayo.
9. I-Colchicine akufanele isetshenziswe iziguli ezithile.
I-Colchicine akufanele isetshenziswe umuntu onokuzivocavoca owaziwa emthini, noma ngesiguli esinomzimba osindayo, isifo senzosa, i-hepatic, noma izifo zenhliziyo. Futhi, iziguli ezinezinkinga zegazi akufanele zisebenzise i-colchicine.
10. I-Colchicine idinga isigqebhezana esibhalwe udokotela wakho.
I-Colchicine iyimithi yokwelapha etholakalayo efomeni elijwayelekile futhi njengegama lomuthi wegama, iColcrys (tablet ye-0.6 mg). Ukuze unciphise imiphumela emibi, i-colchicin ingathathwa ngokudla.
Imithombo:
I-Colchicine. RxList. I-Internet Drug Index. Bukezwe ngo-10/04/2010.
http://www.rxlist.com/colchicine-drug.htm
I-Colchicine. I-MedlinePlus. 02/01/2010.
https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682711.html
I-Colcrys. Buyekeza i-12/2015.
https://www.colcrys.com/
I-Kelley's Bookbook of Rheumatology. Elsevier. Umagazini wesishiyagalolunye. Isahluko 95: Izici Zemitholampilo Nokuphathwa Kwe-Gout - I-Colchicine.