Ucwaningo olusanda kushicilelwa, ososayensi bathola ukuthi abantu abanesifo se-reflux ye-gastroesophageal (GERD), ikakhulukazi labo abanenkinga ye-GERD okuthiwa i- Barretts esophagus , baye bashintsha amangqamuzana e-esophagus equkethe ama-telomeres awancishisiwe, ukulandelana kokuphela ku-DNA strands. Okutholakisiwe kwalolu cwaningo kubonisa ukuthi ukulandelana okufingqiwe kungavumela amanye amaseli ukuthi athambekele emdlalweni ukuze athathe.
Ngokusho kukaDkt. Rhonda Souza, uprofesa ongumxhumanisi wangaphakathi we-UT Southwestern, Ucwaningo lusekela ukuthi kungani lubalulekile ukuvimbela reflux, ngoba reflux xaxa unayo futhi isikhathi eside unakho, kungase kube predispose kuwe ukuthola Barretts esophagus . Ngakho ufuna ukucindezela leyo reflux.
Uma i-GERD ingahambi ingaphathwa kabi noma ingelashwa kahle, isisu se-asidi singakwazi ukuphindaphindiwe ngokuphindaphindiwe. Uma lokhu kwenzeka, kungabangela amangqamuzana ajwayelekile anesikhumba esifundeni ukuba ashintshe zibe nzima, amangqamuzana amaningi anamakhemikhali afana nalawo atholakala esiswini nasemathumbu. Uma lokhu kwenzeka, isiguli siyatholakala ukuthi sinesimo esibizwa nge-Barretts esophagus.
I-Adenocarcinoma yesifo, umdlavuza ohlotshaniswa ne-Barretts esophagus, njengamanje umdlavuza okhuphuka kakhulu e-US, ngokunyuka okuphindwe kasithupha emacaleni eminyakeni engu-30 edlule, ngokusho kweNational Cancer Institute.
Abacwaningi baqhathanisa ubude be-telomere nomsebenzi we-telomerase kuma-biopsy specimens ezivela kwiziguli ezingu-38 ezineGERD neziguli ezingu-16 zokulawula. Lo mkhakha omusha wocwaningo ukhombisa ukuthi i-aclux eqhubekayo eqhubekayo ethinta amangqamuzana amancane ayenza ukuba bahlukane kaningi ukuze kuvuselelwe uketshezi olonakalisiwe.
Noma kunjalo, njalo lapho amangqamuzana ehlukana, ama-telomeres ekupheleni kwe-DNA abe mfushane. Uma beba mfushane kakhulu, iseli eliguga ngeke liphinde lahlukana, uDkt. Souza uthe.
Ososayensi bacabanga ukuthi lapho amangqamuzana engakwazi ukuhlukanisa, amanye amaseli angangenelela endaweni ukuze enze ukulahleka. Futhi lawo maseli angase abe namathuba amaningi okukhiqiza ukumelana ne-asidi okwenza ukuba amathuba okuguqula umdlavuza.
Izinsiza ezihlobene:
Izifo ze-Reflux ze-Gastroesophageal
Isifo se-reflux se-gastroesophageal (GERD), esaziwa nangokuthi isifo se-acid reflux, senzeke lapho isifo esincane esingaphansi kwe-sphincter (LES) singasondeli kahle kahle futhi isisu sesisu siphumelele emuva, noma siphelile, ku-esophagus.I-Esophagus kaBarrett
Isisu sikaBarrett yisimiso lapho i-hoophagus, i-muscular tube ethwala ukudla namathe emlonyeni kuya esiswini, iguqule ukuze ezinye zezingubo zayo zilandelwe uhlobo lwezincubu ezifana nalokho okuvame ukutholakala emathunjini. Le nqubo ibizwa ngokuthi i-metaplasia yamathumbu.I-Cancer Esophageal
I-adenocarcinoma esophageal ngumdlavuza okhula ngokushesha kunazo zonke emhlabeni wesentshonalanga. Izimbangela ezinkulu eziyingozi kulo mdlavuza yizifo ze-Reflux Gastroesophageal (GERD) kanye ne-Barrett's oophagus.