Ingabe i-Oxyde ye-nitric iphethe kulezi zimo?
Abanye abacwaningi bacabanga ukuthi ukugula okungapheliyo (CFS noma ME / CFS ) kanye ne- fibromyalgia (i-FMS) ingaba nombangela ovamile. Omunye umcwaningi uthi lesi sizathu si-nitric oxide futhi futhi sinesibopho se- multiple chemical sensitivity (MCS) kanye nesifo sokucindezeleka ngemuva kokucindezeleka (PTSD).
UMartin Pall, u-PHD, uprofesa we-microbiology eWashington State University futhi waqala ukubheka i-ME / CFS ngemuva kokutholakala ukuthi unayo.
Okuyinhloko yombono wakhe wukuthi ukucindezeleka kwesikhashana kudala ukwakheka kwe-nitric oxide ngokwemvelo, okuqala umjikelezo ononya futhi kuholela ekuguleni kwesikhathi eside.
Kubalulekile ukukhumbula ukuthi le protocol ihlola futhi ayifaka isayensi. Inombolo ekhulayo yezifundo, noma kunjalo, isekela inkolelo yezindlela ezingasebenzi kahle, futhi abanye abantu abaye bazama le protocol bathi sekusebenzele.
Imininingwane lapha ayihloselwe ukusekela noma ukuphikisa inkolelo kaPall kepha ulapha ukukwazisa ngamakhophi atholakalayo nezinqubo zokwelapha ukuze wenze izinqumo ezinolwazi. Kubalulekile ukufaka udokotela wakho ezinqumweni zakho zokwelapha futhi uhlolwe nganoma yiziphi izinguquko empilweni yakho.
I-Oxyde Nitric Emzimbeni Wakho
I-nitric oxide (NO) iphelele emzimbeni wakho futhi idlala izindima ezibalulekile njengokuthonya ukuthutha kwe-oksijini ezithombeni zakho nokudlulisela izimo zesibindi.
Kuze kube sekupheleni kweminyaka engama-1990, okwakubhekwa njengetshevu futhi uPall uyibheka njengombono we-toxin. Ucwaningo oluningi lubonisa izinguquko ezinkambisweni ezinkulu zesisindo zabantu abane-FMS ne-ME / CFS, ne-Pall ethi lezo zinguquko zizodinga amazinga aphezulu we-CHA.
U-Pall uthi amazinga e-NO aphezulu ohlelweni lwezinzwa ezisemkhatsini, aholela emazingeni aphakanyisiwe we-peroxynitrite, okudala ukulimala kwezicubu.
Uthola kanjani u-NO okuningi emzimbeni wakho? I-Pall ikhipha izingcindezi ezingu-12 ezingenzeka, 8 eziholela ekunyuseni okuqondile, 4 okuholela ekungaqondakali. Ukucindezeleka ngokuqondile yilokhu:
- Ukutheleleka nge-viral (ME / CFS, FMS)
- Ukutheleleka kwebhaktheriya (ME / CFS, FMS)
- Ukuhlukunyezwa ngokomzimba (ME / CFS, FMS, PTSD)
- Ukuvezwa kwe-Carbon monoxide (ME / CFS)
- Ukuvezwa kwe-pesticide ye-Organophosphorus (ME / CFS, i-MCS)
- Ukutheleleka kwe-toxoplasmosis (ME / CFS)
- Ukutholakala kwe-organic solvent (volatile solvent solvent) (MCS)
- Izifo ezizenzakalelayo (i-FMS yesibili)
Ezinye izingcindezi ezine zenza impendulo eholela ekwenzeni umsebenzi we-NMDA we-receptor, owaziwa ukwandisa amazinga we-NO ne-peroxynitrite (ONOO-). (Abamukelayo be-NMDA bathumela izimpawu ebuchosheni futhi bangabandakanyeka emonakalweni weseli.) Labacindezeli:
- Ukucindezeleka okukhulu kwengqondo (i-FMS, i-PTSD)
- I-Ciguatoxin exposure (kusuka ekudleni kwezinhlanzi) (ME / CFS)
- I-Organochlorine pesticides (i-MCS)
- I-pesticides ye-pyrethroid (i-MCS)
Qaphela: Awukho amazinga akhuphuka ngenxa yezinto ezithile ezinhle, njengokungathi uzivocavoca, udla ukudla okunamafutha aphansi, ukuthuthukisa umsoco wakho noma ukuyeka ukubhema, konke ochwepheshe abakubona ngenzuzo kubantu abane-FMS ne-ME / CFS. Abacwaningi abaningi bacabanga ukuthi amazinga aphezulu a-NO awungcono empilweni yakho.
I-Cycle Vicious
U-Pall uhlongoza ukuthi uma ukucindezeleka kubangelwa ukwakha u-CHA, kufaka umjikelezo ononya oqukethe amaphuzu amaningana okuzenzekelayo.
Ukusuka lapho, ithola ubuchwepheshe obunzima kakhulu futhi kunzima ukuyiqonda ngaphandle uma unolwazi ngempela mayelana ne-biochemistry. Uma kunjalo, u-Pall unomdwebo ophelele kwiwebhusayithi yakhe. Konke thina, nasi isibonelo sendlela eyodwa nje ye-5-step loop esebenza ngayo:
- Inombolo ephezulu ye-NO yandisa izinga le-peroxynitrite;
- Ukwandiswa kwe-Peroxynitrite kubangela ukucindezeleka kwe-oxidative (ukwakheka kwama-molecule okonakalisa amangqamuzana. Izifundo zixhumanisa ukucindezeleka okwenziwe nge-oxydative kuya ku-ME / CFS);
- Ukucindezeleka okwenziwe nge-oxidative kuvuselela i-NF-kB (elawula ukuveza izakhi zofuzo ezihilelekile emsebenzini wokuzivikela kanye neselula);
- I-NF-kB ikwandisa ukukhiqizwa kwe-enzyme iNOS (inducible nitric oxide synthase);
- I-NOS ikhulisa CHA, futhi sibuyela emuva kwesinyathelo esisodwa.
I-Pall ibize ngokuthi umjikelezo ononya u-NO / ONOO- umjikelezo (ochazwe "cha, o cha!"). Uthi kwenzeke ezingeni leselula, yingakho izicubu ezilodwa zingaba ubuhlungu kuyilapho lezo ezungezile zihle. Ibuye ichaze ukuthi kungani izimpawu zingashintsha kangaka kakhulu kusuka komunye umuntu kuya komunye.
Izimpawu ezabiwe
U-Pall uthi izakhi ze-NO / ONOO- umjikelezo zingachaza eziningi zezimpawu ezabelwana yi-CFS, i-FMS, i-MCS ne-PTSD. ( Uyabanika njengezimbangela ezicacile , hhayi eziqinisiwe.) Lezi zimpawu zihlanganisa:
- Ukufundwa nokukhumbula inkumbulo,
- Ukukhathala nokuphazamiseka kokulala,
- Ubuhlungu obungapheliyo obukhulu,
- Ukucindezeleka nokukhathazeka / ukuhlaselwa kwe-panic,
- Ukungasebenzi komzimba,
- I-syndrome e-irritable syndrome,
- Ukwelashwa kokudla,
- Ukubekezelelana kwe-Orthostatic / hypotension (ukwehla komfutho wegazi uma kumile lokho kukukwenza uhlaziye.)
Ukuqeda Umjikelezo
Ukuze aphule umjikelezo, u-Pall uthi kudingeke ukuba "kulawulwe phansi," okusho ukuthi kuyanciphisa ngokuqeda izinto eziyibangela. Isibonelo, uma ukucindezeleka kukwenza ube nomuzwa obi nakakhulu, kudinga ukunciphisa noma ukuphathwa. Ngaphandle kwalokho, ukholelwa ukuthi ubunzima bomjikelezo kudinga izinhlobo eziningi zokwelapha.
Iphepha likaPall ku-NO / ONOO- umjikelezo uveza izinto eziningi - eziningi zazo izithako zokudla okunomsoco - ukuthi ubikezela ukuthi uzohlehlisa ukulawula umjikelezo. (Khumbula ukuthi le mbono ayiqinisekisiwe futhi lawa ma-agent angatholakali ekuphatheni leli qembu lezifo.) Ubuye abhale izinqubo zokwelapha ezisetshenziswa odokotela abahlanu abaye bathola impumelelo yokwelapha eyodwa noma ngaphezulu yalezi zimo futhi bathi zonke izifo zingase zinciphise lawula umjikelezo. Njengazo zonke izinketho zokwelashwa, kufanele ukhulume nodokotela wakho ngalokho okulungile kuwe.
I-Pall ayiyona yodwa ekhomba i-nitric oxide njengesizathu esithile sezifo. Abacwaningi abaningana abahlola indima ye-NO, ikakhulukazi e-fibromyalgia, bacela izifundo ukuthi ngabe ama-antioxidants ayindlela yokwelapha ephumelelayo.
Ucwaningo
Njengoba incwadi kaPall echaza inkolelo yakhe yavela ngo-2007, inani eliphakeme locwaningo lwenziwa ngendima ye-nitric oxide kulezi zimo.
KuMe / CFS, izifundo eziningana (uSachdeva, Kumar, Gupta) ziye zavela ukusekela le mbono, okungenani kumamodeli wegundane.
Ucwaningo oluthile lwabantu lubuye lubolekise ukwethembeka, kuhlanganise nocwaningo luka-2010 (uSuarez) olukhombisa ukungabikho okungavamile kwama-metabolites ngemuva kokuzivocavoca eM ME / CFS. Ucwaningo olushicilelwe ngo-2014 (uMorris) lubonisa ukuthi ukucindezeleka okwenziwe nge-oxidative kanye ne-nitrosative kungadala izindlela zokuzivikela ezithinta umzimba futhi ezizimele ezigcina izifo zesifo.
Noma kunjalo, okungenani isifundo esisodwa (Meeus) asifumananga ukuxhumana phakathi kwe-NO egazini nasemisebenzini ku-ME / CFS.
Ucwaningo oluningana (uCimen, Fatima, Sendur) nalo lusekela inkolelo yokubandakanya i-nitric oxide ku-FMS. Omunye (Kim) akatholanga umehluko ophawulekayo kuma-NO amazinga phakathi kweqembu le-FMS kanye nokulawula okunempilo.
Ingabe I-Pall Protocol Ikulungele?
Nguwe kuphela onganquma ukuthi iyiphi imithi efanelekile, futhi kufanele uqiniseke ukuthi uzoxoxa nodokotela wakho ngezinketho zakho zokwelapha. Ngaphezu kwezici eziningi zale protocol ezidinga ukubamba iqhaza kukadokotela, kufanele futhi uqaphelwe ngokucophelela ukuqinisekisa ukuthi ukwelashwa akunawo umphumela omubi empilweni yakho.
Imithombo:
Cimen OB, et al. Imithi yobuhlungu. 2009 Jul-Aug; 10 (5): 813-8. I-Arginase, imisebenzi ye-NOS, nezici zomtholampilo ezigulini ze-fibromyalgia.
Fatima G, Das SK, Mahdi AA. I-rheumatology yemitholampilo nokuhlolwa. 2013 Nov-Dec; 31 (6 Isamba 79): S128-33. Ukucindezeleka oxidative kanye nemingcele ye-antioxidative nokuqukethwe kwe-metal ion ezigulini ezine-fibromyalgia syndrome: izimpendulo kwi-pathogenesis yesifo.
Gupta A, Vij G, Chopra K. Journal of neuroimmunology. 2010 Sep 14; 226 (1-2): 3-7. Indima engenzeka yokucindezeleka okwenziwe nge-oxidative nokusebenza kwe-immunological ku-model yegundane yesifo esingapheliyo sokukhathala futhi i-ttenuation ngokukhishwa komnqumo.
Kim SK, et al. I-rheumatology yemitholampilo nokuhlolwa. 2010 Nov-Dec; 28 (6 Isl 63): S71-7. Ukuqina komgogodla kanye nama-cytokines aphefumulayo e-fibromyalgia syndrome.
Kumar A, et al. Umagazini we-Indian of pharmacology. 2011 Meyi; 43 (3): 324-9. Ukuguqulwa kwe-nitric oxide ku-role protective on anti-depressants ngokumelene nesifo esingapheliyo sokukhathala emagundwini.
UMartin L. Pall, isikole seMolocular Biosciences, eWashington State University. Wonke Amalungelo Agodliwe. "I-Novel Disease Paradigm Iveza Izincazelo Zeqembu Eliphelele Lezifo."
Meeus M, et al. In vivo. 2010 Nov-Dec; 24 (6): 865-9. Ukugxila kwe-nitric okwejwayelekile kuyinto evamile futhi akuhambisani nomkhakha womsebenzi ekudleni okungapheli kwesifo: isifundo sokulawula icala.
UMorris G, Maes M. Okwamanje i-neuropharmacology. 2014 Mar; 12 (2): 168-85. Ukucindezeleka oxidative kanye ne-nitrosative nezindlela zokuzivikela emzimbeni eziguli ezine-myalgic encephalomyelitis (ME) / chronic tiredness syndrome (CFS).
USachdeva AK, Kuhad A, u-Chopra K. Brain umbiko wocwaningo. 2011 Oct 10; 86 (3-4): 165-72. I-Epigallocatechin i-gallate ivuselela ukulahlekelwa kokuziphatha nokuphila kwemvelo kwindlela yokulinganisa imithwalo ye-syndrome engavamile yokukhathala.
I-Sendur OF, et al. I-Rheumatology international. 2009, 29 (6): 629-33. I-Serum antioxidants namazinga e-nitric oxide e-fibromyalgia: isifundo esilawulwayo.
U-Suarez A, et al. Umbhalo wempilo yabesifazane. 2010 Jun; 19 (6): 1073-7. Ukukhiqizwa kwe-metabolite yama-nitric ngesikhathi sokuvivinya umzimba ekukhathala kwesifo: isifundo sokulawula icala.