Uma kungesiyo isifo, kungani kufanele ukhathalele?
Ukuba nomzila we-sickle cell kusho ukuthi uyithwala we-sickle cell gene. I-galele cell gene iyingxenye encane ye-DNA eyadluliselwa kubazali, njengokufana nobulili (owesilisa / wesifazane) noma umbala wendwele, okwenza umuntu enze i-hemoglobin ye-sickle.
Ingabe Isigungu Sokugula Siphatha Isifo?
Cha. Lapho uzalwa, unesifo se- sickle cell noma awukwazi. Uma unesifo se-sickle cell angeke sishintshe ku-sickle cell isifo.
Ingabe Ukugula Kwamaselula Kungenza Ngibe Nezinkinga Zempilo?
Akunakwenzeka. Ezimweni ezingavamile, isici segilane singenza imbangela yamangqamuzana egazi abomvu, okuholela ezinkingeni. Ngokuvamile, lokhu kwenzeka kuphela ezimweni ezimbi kakhulu njengokungcola amanzi, amazinga aphezulu, noma amazinga aphansi e-oxygen. Abantu abaningi abanekhwalithi ye-sickle cell baphila impilo yabo yonke ngaphandle kokuphazamiseka okuyisisekelo esingaphansi kwesici se-sickle cell. Kubalulekile ukukhumbula lokhu uma uzizwa ukhululekile ngokuba nomphumela.
Ezimweni ezingavamile, umuntu onesifo se-sickle cell angase ahlakulele umdlavuza wezinso ezingavamile okuthiwa i-renal medullary carcinoma. Ukuxhumeka akuqondakali ngokugcwele, kodwa cishe wonke umuntu oye wahlakulela lo mdlavuza unesifo se-sickle cell (futhi ngezikhathi ezithile isifo se-sickle cell). Ngenxa yalokhu kuxhunyaniswa, ubuhlungu obuphikisanayo obuhlangene / obuya emuva kanye / noma igazi emcimbini (i- hematuria ) kumuntu onesifo se-sickle cell kufanele kuthathwe ngokungathí sina.
Uma Kungabangeli Noma Yiziphi Izinkinga, Kungani Kufanele Nginakekele Ukuthi Ngiyisifo Segciwane Lesiselula?
Ukwazi ukuthi unesici se-sickle cell kubaluleke kakhulu uma usulungele ukuba nezingane. Uma une-tray cell cell, wenza i-hemoglobin A (evamile i-hemoglobin yabantu abadala) ne-hemoglobin S (i-sickle hemoglobin). Lokhu ngezinye izikhathi kufingqiwe njenge-AS.
Ngenhlanhla, umzimba wenza i-hemoglobin A ngaphezulu kune-hemoglobin S, yingakho abantu abanesici se-sickle cell bengenaso izinkinga.
Inkinga ifika uma umlingani wakho futhi enesici se-sickle cell. Isifo se-sickle cell sithola ifa njenge- autosomal condition. Uma bobabili abazali bephethe i-sickle cell trait (AS + AS), kunezinto ezintathu ezinganeni zabo: amaphesenti angu-25 amathuba okuba nengane ene-hemoglobin evamile (AA), ithuba elingamaphesenti angu-50 lokuba nomntwana nge-sickle cell trait (AS) , futhi amaphesenti angama-25 amathuba okuba nengane ene-sickle cell trait (SS). Leli thuba lokuba nengane nge-sickle cell trait kwenzeka ngokukhulelwa njalo, kungakhathaliseki ukuthi kwenzekani ngaphambi kokukhulelwa.
Akukwanele ukwazi ukuthi umlingani wakho unomkhuba wesifo se-sickle noma cha ngoba umzila wesifo we-sickle ungahlanganiswa nezinye izimo ze-hemoglobin njengohlobo lwe-hemoglobin C ne-beta thalassemia. Uma umzali oyedwa ene-sickle trait trait (AS) kanye nezinye izici ze-hemoglobin C (AC), kunezinto ezine: AA (amaphesenti angu-25), i-AC (amaphesenti angu-25), AS (amaphesenti angu-25) no-SC. I-Hemoglobin SC iyindlela yesifo se-sickle cell. Ngokufanayo ugulane beta thalassemia uhlobo lwe-sickle cell isifo.
Ngingayifunda Kanjani Uma Nginezifo Zeselula?
Njengamanje, zonke izingane ezizalwa e-United States zihlolwe isifo se-sickle cell esibukweni esanda kuzalwa .
Lokhu kuvumela izingane nge-sickle cell isifo ukuqala ukwelashwa ngaphambi kokuba izinkinga ziqale. Lokhu kuhlola kuzophinde kubone izingane ezizalwa nge-sickle cell trait. Uma uzalwa ngaphambi kokuthi zonke izingane zivivinywe noma ungazi nje, ungenza udokotela wakho akuhlole ukuthi asebenze kanjani.
Kunezivivinyo ezimbili ezivame ukusetshenziswa ukucacisa isimo se-sickle cell trait. Okokuqala yi-testle solubility test, eyaziwa nangokuthi i-sickledex. Inkinga nge-sickledex ukuthi imiphumela emihle ikutshela kuphela ukuthi i-hemoglobin ye-sickle ikhona yini noma cha. Umphumela omuhle ungenzeka kokubili isifo se-sickle cell kanye nesifo se-sickle cell.
Uhlolo oluthile oluthile luvame ukubizwa ngokuthi i-hemoglobin electrophoresis noma iphrofayli. Lokhu kuhlola kubonisa izinhlobo ezahlukene ze-hemoglobin umuntu anakho. Ngokuvamile, abantu abanesici se-sickle cell benza cishe amaphesenti angu-60 i-hemoglobin A ne-40% ye-hemoglobin S.
Nakuba ukuphathwa kwe-sickle cell akufanele kubangele izinkinga, ukwazi ukuthi isimo sakho sensimbi yesilwane (kanye nomlingani wakho) sizokusiza ukuba uqonde ingozi yokuba nengane enegciwane lesifo segciwane esikhathini esizayo.