Ukusetshenziswa, imiphumela emibi, isilinganiso, nokusetshenziswa kwe-methotrexate ekukhulelweni
Yini I-Methotrexate?
I-Methotrexate ingokwezigaba zemithi eyaziwa njenge-antineoplastics. I-Antineoplastics igwema izinqubo zamakhemikhali zomzimba, ezifana nokukhiqizwa kwe-DNA nokuhlukaniswa kwamaseli. Ziwusizo emitholampilo yokwelapha, ngoba zizovimbela umdlavuza wamangqamuzana ukuba uphumelele. I-Methotrexate nayo inganikezwa ukuphatha i-akylosing spondylitis, i-rhumatoid arthritis, i-psoriasis nesifo sika-Crohn
Kuthathwa kanjani i-Methotrexate?
I-Methotrexate kufanele ithathwe ngokufana nalokho okushiwo udokotela. Ukusebenza ngokomzimba kuzokusiza ukulinganisa izidingo zesiguli ngasinye. I-Methotrexate inganikezwa njenge-tablet, ukumnika noma umjovo. Uma kuthathwa kanye ngesonto, kungcono ukuthatha ngosuku olufanayo njalo ngesonto.
Kungani I-Methotrexate Echazwe?
Ngenxa yokuthi i-methotrexate ivimbela i-cell metabolism, inqunyelwe izimo lapho ukukhula kwamangqamuzana okungavamile kuyinkinga, njenge- psoriasis noma umdlavuza. I-Methotrexate itholakale iwusizo ekwelapheni ezinye izimo zesifo sikaCrohn nesifo samathambo . I-Methotrexate nayo isetshenziselwe ukukhipha isisu ngokukhulelwa kwe-ectopic.
Ubani Akufanele Athathe Methotrexate?
Tshela udokotela wakho uma uke waba nalezi zimo ezilandelayo:
- Okwamanje ukhulelwe
- Isifo sezinso
- Isifo sesibindi noma i-cirrhosis
- Isifo se-Lung noma fibrosis
- Izifo ze-neurologic
- Izifo ezijwayelekile
Yiziphi Imiphumela Ezingezansi?
Imiphumela emibi ye-bothersome ye-methotrexate ihlanganisa ikhanda, ukulala, ukuwashaza, ukuqhwala isikhumba, isizungu, nokulahleka kwezinwele.
Imiphumela emibi kakhulu ihlanganisa ubuthi besibindi, umnkantsha noma, ngokungajwayelekile, amaphaphu. Bheka ikhasi leminye imiphumela ye - methotrexate uhlu oluphelele.
Ingabe Kukhona Ukusebenzisana Ukudla?
Iziphuzo ezidakayo akufanele zisetshenziswe ngenkathi zithatha methotrexate, njengoba zingabangela ukulimala kwesibindi, okuholela ekutheni i-cirrhosis.
Yimiphi Imithi Engayifaka I-Methotrexate?
Abantu abasebenzisa i-methotrexate kufanele bagweme ukugonywa ngegciwane bukhoma. I-Methotrexate ibangela ukuthi isimiso somzimba samasosha omzimba singasuswa, ngakho-ke ukugoma komgogodla ophilayo kungabangela ukugula esikhundleni sempendulo yomzimba.
I-FDA ikhuthaza ukuqapha ngokuthatha i-methotrexate kanye ne- proton pump inhibitor (PPI) , okuyizidakamizwa ezisiza ukunciphisa inani le-asidi esiswini. Amanye ama-PPI avamile ahlanganisa i- Prilosec (i- omeprazole), i- Nexium (esomeprazole) , ne- Protonix (i-pantoprazole). Ukukhathazeka kuboniswe ikakhulu kulabo abathatha isilinganiso esiphezulu se-methotrexate. Inkinga ukuthi ama-PPIs angandisa amazinga e-serum (inani elitholakala egazini) le-methotrexate. Amazinga aphezulu e-serum angasho ukuthi kunesisindo esinobuthi semettretrexate ekwakheni umzimba. Imiphumela ephelele yalokhu kusebenzisana isacwaningwa, kodwa manje i-FDA ikhishwe isixwayiso mayelana nokuthatha i-methotrexate kanye ne-PPI.
I-Methotrexate ingase ihlanganyele nemithi elandelayo:
- Izidakamizwa ze-arthritis (ibuprofen, Advil, Motrin, Naprosyn, Voltaren, Lodine)
- I-aspirini noma amanye ama-salicylate
- I-Azathioprine (Imuran)
- I-subsalicylate ye-Bismuth (i-Pepto Bismol)
- I-Carbenicillin (i-Geocillin)
- I-Cholestyramine (i-Questran)
- I-Blood thinners (i-Coumadin)
- I-Cyclosporine (i-Sandimmune, i-Neoral)
- I-Digoxin (i-Lanoxin)
- Etretinate (Tegison)
- I-Phenytoin (i-Dilantin)
- I-Probenecid
- I-Proton pump inhibitors (i-PPIs)
- Izidakamizwa ze-Sulfa (i-Bactrim)
- I-Thiazide diuretics (i-Dyazide, i-hydrochlorothiazide)
Ingabe I-Methotrexate Safe Safe During Ukukhulelwa?
I-FDA ihlukanise i-methotrexate njengomuthi we-X uhlobo. Lokhu kusho ukuthi ukuhlolwa kwezilwane noma abesifazane abakhulelwe kubonise ubufakazi obuhle bokungalingani kokubeletha. I-Methotrexate akufanele isetshenziswe ngesikhathi sokukhulelwa njengoba ingabangela ukukhulelwa kwesisu noma ukukhubazeka kokuzalwa embungu. Amadoda kufanele ayeke i-methotrexate okungenani izinyanga ezingu-3 ngaphambi kokukhulelwa.
Abesifazane kufanele bayeke methotrexate ngomjikelezo owodwa ovulation ogcwele ngaphambi kokukhulelwa. I-Methotrexate idlula ubisi lwebele, futhi ingathinta ingane engumntwana. I-FDA incoma ukuthi i-methotrexate ingasetshenziselwa abesifazane besifo sokubeletha ngaphandle kokuthi "kukhona ubufakazi obucacile bezokwelapha ukuthi izinzuzo zingalindelwa ukuba zivelele izingozi ezicatshangelwe."
I-Methotrexate Yingakanani Ingathathwa Ngokuphepha?
I-Methotrexate ingathatha amasonto ambalwa ukuthi iphumelele ekwelapheni isifo sikaCrohn. Kumele kuthathwe isikhathi eside (izinyanga noma iminyaka) ngaphansi kokuqondiswa okudokotela kadokotela.
Umthombo:
Hospira, Inc. "I- Methotrexate Injection, i-USP ." FDA.gov. Okthoba 2011.
Ulwazi lweMithi yamaMicromedex. "Methotrexate (Ngomlomo)." I-PubMed Health. Dec 2015.