Ubufakazi Nokuphikisana Nokuthatha I-Probiotic ye-Crohn's noma i-Ulcerative Colitis
Indlela i-microbiome yethu eyithinta ngayo ukuthuthukiswa kwesifo sofuba esiswini (IBD) isihloko esishisayo kokubili ukuxoxisana nokucwaninga. I- microbiome ibhekisela kuwo wonke ama-microorganisms (amabhaktheriya nama-microbes) ahlala emzimbeni wethu. I-microbiome yamathumbu amakhulu ikakhulukazi ihlolwe ngokuphathelene nesifo sikaCrohn nesifo sofuba, ngenxa yombono wokuthi i-IBD ibangelwa ukuphazanyiswa kwe-microbiome, noma ukuthi i-IBD ibangela lokho kuphazanyiswa.
Ukulandela okuvela kulokho umqondo wokuthi uma i-microbiome ingalungiswa, futhi ukuxuba "okulungile" kwama-bacteria kungalinywa endleleni yokugaya, ukuthi i-IBD ingathinteka noma ifakwe ngisho nokuphathwa.
Faka ama-probiotics , angama-bacteria "anobungane" asetshenzisiwe, noma ngokuwadla noma ngokuthatha isengezo. Ama-probiotics ayabiza, futhi ukuthandwa kwabo kuyanda, kodwa bayakufanelekela yini ukutshalwa kwemali uma kuziwa ku-IBD? Futhi okunye okunye: Abalawulwa yi-Food and Drug Administration, ukuphakamisa umbuzo wokuthi kungakhathaliseki ukuthi bangabangela yini umonakalo.
Amaphuzu abalulekile okumele agcine engqondweni mayelana nokusebenzisa ama-probiotics ku-IBD:
- Akukaqondwa ngokuphelele ukuthi i-microbiome ithinteka kanjani yi-IBD.
- Amanye ama-probiotics angasebenza ngempumelelo ku-IBD, kodwa ucwaningo oluningi luyadingeka.
- Enye ye-probiotic etholakalayo ezentengiso iboniswe ngempumelelo ye- pouchitis kubantu abane-j-pockets.
- Ama-probiotics angabiza futhi ngaphandle kokuthi kusetshenziswe uhlobo "olungile", angeke lunikeze noma iyiphi inzuzo.
- Ama-probiotics angase abe yingozi kubantu abaye banciphisa amasosha omzimba kanye nasezinsaneni.
- Izithako ze-probiotic kufanele zisetshenziswe eselulekweni sodokotela.
Iyini i-Microbiome Njengabalingane be-IBD?
Kuyaziwa kakade ukuthi abantu abane-IBD banamaphilisi ahlukene wezinto eziphilayo endleleni yabo yokugaya kunabantu abanempilo.
I-microbiome ihluke kakhulu: Wonke umuntu uzoba nenguqulo yakhe "evamile." Noma kunjalo, kunezimo ezincane ezincane ezitholakala kubantu abane-IBD abatholwe abacwaningi. Indlela lokhu kuhlobana ngayo nezimpawu kanye nokwelashwa akukaziwa. Ngakho-ke, kuyaqondakala ukuthi kunezinguquko kumuntu omncane we-IBD kodwa akwaziwa ukuthi lokhu kuthinta i-IBD nokuthi uma kukhona okunye okudinga ukuphathwa noma kungaphathwa kahle.
Ingabe ama-Probiotics ayingozi?
Kunombono wokuthi ama-probiotics ayakulungeka futhi ayadingeka futhi kuhle ukuba "uzame" futhi ubone ukuthi kusebenza kanjani, ngoba akunazimo ezimbi. Ezimweni eziningi, ikakhulu kubantu abadala abadala, ama-probiotics cishe ayingozi. Abantu abaningi badla ama-probiotics ekudleni kwabo nsuku zonke, ikakhulukazi e-yogurt, kombucha, noma e-kefir. Kodwa-ke, kwamanye amaqembu, njengalabo abagula kakhulu, aye buthakathaka amandla omzimba, noma izinsana, isibonelo, izithako ze-probiotic zingase zidale ingozi. Kuyinto engavamile, kodwa imiphumela emibi ibike, ikakhulukazi ezinsaneni ezigulayo ezanikezwa ngama-probiotics.
Njengoba singasazi ukuthi yiziphi izinto eziphilayo noma ukuthi zingakanani zazo ezidingekayo ukulungisa i-microbiome yethu ngendlela enhle, ukusebenzisa ama-probiotics kubantu asebevele begula noma asebekhulile kungenzeka ukuthi bangaphephile.
Ayikho ubufakazi obanele bokuthi behlezi ngalolu daba ngandlela-thile, kodwa ukuvumelanisa okujwayelekile kule ndawo ukuthi ama-probiotics ayingozi, futhi udokotela kufanele abonisane ngaphambi kokuwasebenzisa.
Indlela Yokutshela Uma I-Probiotic Isebenza
Kwabanye abantu, ukuthatha i-probiotic kungase kubangele ukudala igesi nokuvimbela. Ukuqala ngomthamo ophansi futhi ukwandise kancane ngokuhamba kwesikhathi kungasiza ekunciphiseni lezi zinhlobo zemiphumela emibi. Noma yikuphi ukungahambi kahle noma eminye imiphumela kufanele ifakwe phakathi kwesonto noma amabili. Uma kungenjalo, sekuyisikhathi sokuhlola kabusha leyo probiotic ethile nodokotela. Kungaba yinselele ukwazi uma i-probiotic isebenza.
Kumuntu onesitokisi esibucayi, uma isitebe siqinile okungase kube yinkomba yokuthi i-probiotic iyasebenza. Kodwa uma i- IBD ixoxisiwe , futhi i-probiotic isetshenziswa ukuhlala ngaleyo ndlela: kunzima ukwazi ukuthi isebenza yini. Lesi esinye sezizathu eziningi zokuthi kungani kubalulekile ukuxoxa ngama-probiotics nodokotela nokugcina idayari yesibindi uma uqala i-probiotic entsha.
I-probiotics yezifo zika-Crohn
Izivivinyo zama-probiotics kubantu abadala abanesifo sikaCrohn ekuxoxweni baye babonisa imiphumela ehlanganisiwe ngama-probiotic supplements, nakuba kungacacile ukuthi yimiphi imithi ezoba usizo. Ukuhlaziywa kwe-meta (okuyinto lapho abacwaningi befunda imiphumela yezifundo eziningana ukuze bafike esiphethweni) kwezilinganiso eziyisishiyagalolunye ezinjalo azibonisi inzuzo kubantu abane-Crohn's disease. Kungase kube nenzuzo ebonwe lapho kusetshenziselwa izinhlobo eziningana ndawonye, ikakhulukazi i- Saccharomyces boulardii , i- Lactobacillus , ne-VSL # 3 (okuyinto umkhiqizo wezohwebo oqukethe umxube wezinkinga ezingu-8 zebhaktheriya).
Kodwa-ke, kwakukhona izilingo ezintathu ezibandakanywa kulo meta-analysis obonisa "inzuzo ebalulekile" yezingane eziphila nesifo sikaCrohn esizongezwa ngama-probiotics. Kumele kuqashelwe ukuthi lezi zivivinyo, okusho ukuthi izingane zazizinakekelwa udokotela, zithola ukuqapha okusheshayo, nokuthi ama-probiotics akufanele asetshenziswe kubantwana abane-IBD ngaphandle kokuxoxa nodokotela.
Ama-probiotics ku-Ulcerative Colitis
Ukuhlaziywa kwe-meta okwabheka izilingo ezingu-18 zama-probiotics eziguli eziphila ne-ulcerative colitis zaphetha ngokuthi "kwaba nomthelela omkhulu." Abacwaningi baphawula ukuthi ama-probiotic ahlangene aboniswe ukuthi aphumelela kakhulu kubantu abane-ulcerative colitis. Ukwengeza nge- lactobacillus probiotic kanye nama-prebiotics kwakuphumelele ekulweni kwe-ulcerative kodwa hhayi kwisifo sikaCrohn. Ukuhlanganiswa kwezebhizinisi i-VSL # 3 kuboniswe ukuthi kuphumelele ekulweni kwe-ulcerative colitis, futhi uma kuhlangene noLactobacillus, kuboniswe futhi ukuba nomthelela ezinganeni ezine-IBD. Futhi, kufanele kuqashelwe ukuthi ukusetshenziswa kwama-probiotics kubantu abane-IBD kufanele kwenziwe ngaphansi kokuqondiswa udokotela, ikakhulukazi uma kwenzeka izingane ziphethe lesi sifo.
I-probiotics ye-J-isikhwama
Kukhona iqembu elilodwa labantu abane-IBD abaye baboniswa ukuthi ama-probiotics abalulekile, futhi yibo bantu abane-j-poch. Ukuhlinzekwa kwe-J-pouch uhlobo lwenqubo eyenziwa ngabantu abane-ulcerative colitis, futhi igama lobuchwepheshe liyi-poal-anal anal anastomosis (i-IPAA). Phakathi nalokhu kuhlinzwa, ikoloni isusiwe, kanye nenxenye noma yonke irectum. Ingxenye yokugcina yamathumbu amancane ifakwe esikhwameni esithatha indawo ye-rectum futhi ifakwe kwi-anus.
Enye ingcindezi engaba khona ye-j-pouch yisimo esibizwa nge- pouchitis , esiletha izimpawu zokuhuda, umkhuhlane, ukuphuthuma, kanye nezikhathi ezithile zamanzi. I-Pouchitis ayiqondakali kahle, kodwa kunobunye ubufakazi bokuthi ukusetshenziswa okuvamile kwama-probiotics kungasiza ekuvimbeleni ama-pults of pouchitis. Olunye uhlobo lwe-probiotics, oluyimpahla futhi olwenziwa yinkampani eyodwa kuphela, luye lwahlolwa futhi imiphumela ibonisa ukuthi ingasiza ekuvimbeleni i-pouchitis noma igcine isiguli ekuxoxweni ngemuva kwe-pouchitis iselashwe ngama-antibiotics. Ukuhlukumezeka ukuthi ama-probiotics ayabiza futhi kaningi ayengahlanganiswa nomshuwalense ngenxa yokuthi abhekwa njengesixazululo hhayi imithi.
Ingabe i-Probiotics izoba "ikhambi" ye-IBD?
Ngenkathi kunezifundo ezithile ezibonisa izinzuzo zokuthatha izinhlobo ezithile zama-probiotics ngamanye ama-subtypes a-IBD, umphumela ngeke ube ophawulekayo ngokwanele ukuba uthathwe njengomuthi. Ama-probiotics angasiza abanye abantu abane-IBD, kodwa kubalulekile ukuqaphela ukuthi ngeke baphumelele ngokwanele ukuthi iziguli zingayeka ukuphuza imithi ye-IBD.
Izwi elivela
Ukusetshenziswa kwama-probiotics ukuphatha i-IBD kubheka okuthembisayo. Kodwa-ke, kusekhona imibuzo eminingi okufanele iphendulwe, ikakhulukazi ukuthi i-microbiome ithinteka kanjani ngaphambi kokuqala kwe-IBD nokuthi iyashintsha kanjani uma i-IBD ihluma futhi uma isemthethweni. Kunezinhlobo eziningi ezihlukahlukene zezinyunyana ezincane ezitholakala emgodleni wokugaya ukuthi kuyinselele ukunquma ukuthi yiziphi amagciwane okufanele asetshenziselwe ukushintsha ibhalansi. Abacwaningi bahlonipha ukuthi yiziphi izinkinga ezingase zibe usizo, kodwa kusekhona okungaziwa okuningi kunalokho okuyaziwa kule ndawo. Kuze kube khona idatha yocwaningo, akucaci okwamanje ukuthi ubani ongase azuze ekuxhaseni kwama-probiotic. Kungakhathaliseki ukuthi kufanele yini ukusebenzisa i-probiotic ingxoxo okufanele iyenze phakathi kukadokotela nesiguli ngoba yisinqumo ngasinye. Esikhundleni sokuthi "zama futhi ubone," udokotela anganikeza isiqondiso esithile lapho izinkinga zebhaktheriya zingase zibe usizo.
> Imithombo:
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