Hlola Ingozi Yakho Yokuthuthukisa Izifo Ezibucayi
Isifo se-Celiac sihlotshaniswa nokuzalwa, okusho ukuthi wena kuphela ongahlakulela i-celiac uma uphatha izakhi zofuzo ezikubeka phambili. Ngakho-ke, odokotela bayaqhubeka bezama ukuhlola ukuhlolwa kwesifo sofuzo ukuze bathole ukuthi ngabe umuntu unesimo esithile sokuthuthukisa isimo.
Cishe wonke umuntu udla i-gluten, iphrotheni etholakala okusanhlamvu, ibhali kanye ne-rye.
Kodwa-ke, kubantu abanogciwane elifanele, ukungena kwe-gluten kungaholela ekugcineni ekufikeni kwesifo se-celiac, isimo esizimele esenza ukuthi isifo sakho-silwe namaseli amhlophe egazi ukuhlasela umbhede wesisu sakho esincane.
Akuwona wonke umuntu ophethe izifo zofuzo ze-celiac ekugcineni azokuhlakulela isifo se-celiac-empeleni, kuyilapho abantu abangaba ngu-40% benesifo esisodwa noma zombili izifo ezidingekayo, kuphela u-1% wabantu abanesifo se-celiac. Ngakho-ke ukuba namandla okusebenzisa izakhi akusho ukuthi uzotholakala ukuthi unesifo se-celiac kanye nesidingo sokuyeka i-gluten; Empeleni, izinkinga zithinteka kulo.
Kodwa-ke, ukuhlolwa kofuzo kwesifo se-celiac kunganikeza esinye isici kwi-puzzle ye-diagnostic, ikakhulukazi ezimweni lapho ukuhlonza kwakho kungacacile khona noma lapho uzama ukunquma izidingo zokuhlola esizayo.
Ukuhlolwa Kwezifo Zama-Celiac Ukuhlolwa Kwezakhi Zofuzo Kubukeka I-Genetic Two
Beka nami-lokhu kuyinkimbinkimbi.
Izakhi zofuzo ezikubeka esilweni sesifo se-celiac zitholakala kwi-HLA-class II eyinkimbinkimbi ye-DNA yethu, futhi yaziwa njengezakhi zofuzo ze-DQ.
Wonke umuntu unamakhophi amabili wegciwane lesandulela ngculaza-elilodwa kusuka kumama wabo nenye evela koyise. Kunezinhlobo eziningi zezakhi zofuzo ze-DQ, kodwa kunezinhlobo ezimbili ezibandakanyeka eziningi zezimo ze-celiac izifo: HLA-DQ2 ne- HLA-DQ8 .
Kulawa, i-HLA-DQ2 iyindawo evame kakhulu kubantu abaningi, ikakhulukazi kubantu abanamagugu aseYurophu-abangaba ngu-30% noma ngaphezulu abantu abakhokho babo abakhohliswa kulowo mhlaba baphatha i-HLA-DQ2.
I-HLA-DQ8 ibhekwa njengeyinqaba, ibonakala cishe ngo-10% wendawo yonke, nakuba ijwayelekile kakhulu kubantu abavela eCentral naseNingizimu Melika.
Ucwaningo lubonise ukuthi cishe abantu abangamaphesenti angu-96 abantu ababhekene ne-biopsy abanezifo ze-celiac bathatha i-DQ2, i-DQ8 noma enye inhlanganisela yale mibini. Njengoba uthola i-DQ yegciwane elilodwa kusuka kumama wakho nenye evela kubayihlo, kungenzeka ukuba ube namakhophi amabili e-DQ2, amakhophi amabili e-DQ8, ikhophi eyodwa ye-DQ2 kanye ne-DQ8, noma ikhophi eyodwa ye-DQ2 noma i-DQ8 ehlangene esinye isakhi se-DQ.
Kunoma ikuphi, uma uthwala ikhophi eyodwa ye-DQ2 noma i-DQ8, uthathwa njengengozi enkulu kakhulu yesifo se-celiac. Kunobufakazi bokuthi ukuthwala amakhophi amabili kwesinye sezakhi zofuzo (noma i-DQ2 noma i-DQ8) kungandisa ingozi yakho nakakhulu.
Okungenani isifundo esisodwa sibonisile ukuthi esinye isakhi esiqondile, i- HLA-DQ7 , futhi sibeka abantu phambili kwisifo se-celiac. Eqinisweni, kulolu cwaningo, abantu abangamaphesenti angu-2 abanesifo se-biopsy-esiqinisekisiwe se-HLA-DQ7, kodwa hhayi i-DQ2 noma i-DQ8. Kodwa-ke, kukhona ukungqubuzana ngokuthi ngabe i-DQ7 empeleni ikubeka yini kwisifo se-celiac, futhi ukuhlolwa kofuzo e-US okwamanje akubona i-DQ7 "njengesifo sofuzo se-celiac."
Ngaphezu kwalokho, ucwaningo olusha lubonisa ukuthi awudingi ukuthwala i-HLA-DQ2 noma i-HLA-DQ8 ukuze uthuthukise ukuzwela okungenayo i -celiac gluten .
Kungase kube nezinye izakhi zofuzo ze-HLA-DQ ezibandakanyeka ekuzweleni kwe-gluten; funda kabanzi ku- Ingabe udinga izakhi zofuzo ezithile ukuze uthuthukise ukuzwela kwe-gluten?
I-Celiac Gene Test ihlanganisa isikrini esilula
Ukuvivinya izakhi zofuzo ze-celiac akuyona into engavamile nhlobo. Uzohlinzeka nge-laboratory ngesampula segazi lakho, sebenzisa i-swab ukuze uqoqe ambalwa amaseli angaphakathi kwesigama sakho, noma usebenzise i-syringe noma i-vial ukuze ubuthe amanye amathe. Igazi lakho, amahlathi noma amathe, bese uhlaziywa yi-laboratory; noma iyiphi yalezi zindlela iveza imiphumela enembile ngokunembile.
Iningi labantu linokuhlolwa kofuzo okwenziwe ngokuhambisana nezinye izivivinyo ezigunyazwe udokotela wazo.
Noma kunjalo, kungenzeka (nakuba kuyabiza) ukuthola ukuhlolwa ngaphandle kokuba udokotela ahileleke.
Kunezindawo ezimbili ongazihlola ngazo okwenziwa ngaphandle kwe-oda lomdokotela: I-Enterolab, i-laboratory ekhethekile e-Dallas (i- Enterolab iphinda yenza ukuhlolwa kokuzwela kwe-gluten ), kanye nensiza yokuhlola i-genetic 23andMe.com.
Ngama-$ 150 (okukhokhwa ngesikhathi ubeka umyalelo), i-Enterolab izohlaziya izakhi zakho zofuzo futhi ikutshele ukuthi yiziphi izakhi zofuzo ze-HLA-DQ ozithwalayo, kufaka phakathi ukuthi uthwala enye yezinhlobo ezimbili eziyinhloko zesifo se-celiac. Isivivinyo senziwa ngamaseli aqoqwe nge-swab ngaphakathi kwesigama sakho, ngakho-ke awekho ukudweba kwegazi okuhilelekile. Uma ususa isifuba sakho bese uthumela umklamo wesampula, imiphumela yakho ithunyelwa nge-imeyli kuwe cishe emavikini amathathu.
Nge-23andMe.com, okwamanje, uzokhipha isikhala bese uthumela i-vial off ukuze ihlolwe. Le nkampani inikeza ukuhlolwa kwesifo sofuzo nge-celiac nge-"Health and Ancestry", okubiza nge $ 200. Umbiko wakho uzophinde unikeze ngolwazi oluningiliziwe ngobukhokho bakho, kanye nedatha ngezihlobo zofuzo.
Ukuvivinya I-Genetic Akufananga Nokuthola Ukulinganiswa
Njengoba akuwona wonke umuntu ophethe i-celiac gene winds uphethwe ngokuthi unesifo se-celiac (abantu abaningi abayitholi isimo ngisho negciwane, empeleni), ukuvivinywa okufuzekile kofuzo akufani nokuxilongwa. (Bheka: Ngihlolwe kahle kuhlolwa lwami lwe-gene eliyi-celiac. Ingabe kufanele ngihambe ngaphandle kwe-gluten? )
Yonke isifo sakho esihle se-celiac isifo sokuthi ufuzo lunikeza wena ukuthi yini odokotela abayibheka njengeqembu "eliphakeme kakhulu" lesifo se-celiac. Ngakho-ke, izivivinyo zesifo sofuzo ze-celiac ziwusizo kakhulu ukulawula isifo se- celiac lapho kwenzeka khona izimpawu ze-celiac . Kwezinye izimo, umuntu angase abe nemiphumela yokuhlolwa ye-celiac engaqiniseki, futhi ukuhlolwa kofuzo kungasiza udokotela ukuba ahlolwe kahle.
Ukuhlola kwe-Gene nakho kuyasiza ukulawula isifo se-celiac emalungwini omndeni we-celiacs atholakalayo. Ukuhlolwa kwesifo se-Celiac ngezihlobo kunconywa uma omunye umuntu emndenini wakho etholakele, kodwa uma wazi ukuthi uthwala isifo sofuzo se-celiac, kufanele ulandelwe eduze kakhulu.
Okokugcina, kungenzeka ukuthi usebenzise izivivinyo zofuzo ukuze ubone ukuthi isifo se-celiac kungenzeka yini kumuntu osevele esidla ukudla okungenamsoco we- gluten .
Kudingeka udle i-gluten yokuhlolwa kwesifo se-celiac ezivamile ukuze kube neqiniso. Kodwa-ke, abanye abantu bayaqaphela ukuthi ukudla i-gluten-free kwenza bazizwe beba ngcono, futhi basuse amaprotheni avela ekudleni kwabo ngaphambi kokuhlolwa kwesifo se-celiac. Uma kamuva benquma ukuthi bafuna ukuxilongwa, banokukhetha okubili: zama inselele ye-gluten , noma bahlole ukuhlolwa kofuzo.
Akudingeki ukuba udle i-gluten yesifo se-celiac yesifo segciwane-futhi, ukuhlola kuphela okunquma uma unamandla okuthuthukisa isifo se-celiac, hhayi uma unayo ngempela. Ngakho-ke, nakuba ukuhlolwa kofuzo kungakwazi ukunikeza izimpendulo eziphelele mayelana nokuthi ngabe unesifo se-celiac, abantu abaningi bayithandayo enselele ye-gluten ngoba ayifuni ukuba babuyele ku-gluten ukuthola ulwazi oluthe xaxa mayelana nesimo sabo.
Kuningi esingakasazi ngesifo se-celiac, futhi akucaci ukuthi kungani abanye abantu abanezifo ze-celiac ezifuywayo bezithuthukisa kanti abanye bengazi. Noma kunjalo, ukuhlolwa kwesifo se-celiac isifo sokubeletha kungasiza ekunqumeni ingozi yesimo emalungwini omndeni, futhi ezimweni ezingacacile ngokuphelele-ukusika.
Imithombo:
Isikhungo Sezifo ZamaCeliac e-Columbia University. Ukuhlolwa kwe-Serologic ne-Genetic. Ifinyelele ngo-Jan. 5, 2012.
Izikhungo zezempilo zikazwelonke. I-NIH Ingqungquthela Yokuthuthukiswa Kwentuthuko Yezifo Ezibucayi. Ifinyelele ngo-Jan. 5, 2012.
Sacchetti L. et al. Ukubandlulula phakathi kwezimo ezibucayi ze-Celiac nezinye zezinsizwa ebuntwaneni nge-Rapid Human Lymphocyte Typing Typing. I-Chemistry Clinical. Agasti 1998, Umq. 44, No. 8, k. 1755-1757.
Isikhungo se-University of Chicago Celiac Disease. Ukuhlolwa kwe-Genetic . Ifinyelele ngo-Jan. 5, 2012.