I-Genetics ixhunywe engozini yokugula okuzenzakalelayo
Isifo se-Celiac yisifo esizimele esisodwa lapho kudla khona i-gluten kungabangela izimpawu zamathumbu kanye nokulimala emathunjini amancane. Kuyinto isifo esingaqondakali ngokugcwele kodwa sibonakala sixhunyaniswe ngokuqinile engxenyeni yezofuzo zomuntu.
Siyakwazi lokhu kusukela ebusweni obanzi njengoba nje ingozi yesifo se-celiac ikhula kakhulu uma isihlobo sokuqala, njengomzali noma umntakwethu, sinesifo.
Eminyakeni yamuva, ngokufika kokuhlolwa kofuzo , ososayensi baye bakwazi ukubona izakhi zofuzo ezimbili ezibonakala zivame kakhulu kubantu abanesifo se-celiac. Ziyingxenye yeqembu lezakhi zofuzo ezibizwa ngokuthi i-leukocyte antigen yabantu (HLA) futhi zifaka:
- I-HLA-DQ2, ekhona kumaphesenti angaba ngu-90 abantu abanesifo se-celiac
- I-HLA-DQ8, ebonakala ngamaphesenti angaba ngu-8 wesilinganiso esifanayo
Ngenkathi i-HLA-DQ8 ingase ibonakale iyimbangela encane yokucindezela, ilandisa ngobuningi bama-non-DQ2 amacala futhi inezinye izici ezenza kube ngokuphawulekayo ukushaya.
Xhumanisa Phakathi kwe-HLA-DQ8 ne-Celiac Disease
Kunezinhlobo eziningi ezahlukene (ama-serotypes) wezakhi zofuzo ze-HLA-DQ ezenziwa yi-DQ2 ne-DQ8 kuphela. Njengeqembu, umsebenzi wabo oyinhloko ukusiza umzimba ukuthi uqaphele ama-agent angase abe yingozi, okuvumela isimiso somzimba sokuzivikela sikwazi ukubhekisisa lawo maseli ukuze athole i-neutralization.
Ngamunye wethu unamakhophi amabili e-serotype ye-HLA-DQ, eyodwa esiyizuza kumama wethu kanye nenye esiyizuza kubaba.
Uma umuntu ezuza ifa elifanayo le-HLA-DQ kubazali bakhe, kuthiwa u-homozygous. Uma lo muntu ezuza i-izinhlobo ezimbili ezahlukene, okuthiwa yi-heterozygous.
Njenge-serotype eyingqayizivele, i-HLA-DQ8 ivame ukuxhunyaniswa nezifo ezizimele ezibandakanya izifo ze- celiac, isifo samathambo esifubeni , nesifo sikashukela sobantwana .
Ngenxa yezizathu ezingaziwa, lesi sakhi singakwazi ukuzivikela umzimba, siqondise amasosha omzimba ukuhlasela nokubhubhisa amaseli awo.
Ngokuqondene nesifo se-celiac, ucwaningo luye lwabonisa ukuthi ukuba i-HLA-DQ8 i-homozygous kwandisa ingozi yakho ngokuphindwe kabili uma kuqhathaniswa nomphakathi jikelele. Ngisho nekhophi eyodwa HLA-DQ8, ingozi yakho ngaphezu kokuphindwe kabili.
Nokho, i-heterozygosity ayisho njalo ingozi encane. Uma uhlanganisa i-HLA-DQ8 nge-high-risk version ye-HLA-DQ2, amathuba akho esi sifo ahlasela izikhathi ezingaba ngu-14 zomphakathi jikelele.
Indlela i-DQ8 eyahluka ngayo ngesiFunda
Inkulumo i-HLA-DQ8 ingahluka kakhulu kusuka kwenye ingxenye yezwe kuya kwesilandelayo. EYurophu, isibonelo, yisifo esiningi esihlobene nesifo sikashukela kanye nesifo sikashukela sezingane. Ngokufanayo, eJapane, lapho lena engekho i-HLA-DQ2, i-serotype ye-DQ8 iyona yodwa imbangela yesifo se-celiac (okuqinisekisiwe, ngokwengxenye, ngokunyuka kwe-gluten ekudleni kwaseJapane).
Ngokuqhathanisa, i-HLA-DQ8 imelela ingxenye encane yezimo zesifo se-celiac e-US futhi ngokuvamile ihlotshaniswa ne-arthritis ye-rheumatoid. Akukhona lokho okubalulekile ngokuhambisana nokukhula kwesifo. Kuze kube manje, akukho siphakamiso sokuthi i-serotype inomthelela obunzima besifo.
Ngenxa yalokho, kungenzeka ukuthi ezinye izici zidlala indima yokuthi kungani abanye bethola lesi sifo sibi nakakhulu kunabanye.
> Umthombo:
> Tjon, J .; van Bergen, J .; kanye noConing, F. "Isifo se-Celiac: ingabe kunzima kangakanani ukuthola?" Immunogenetics . 2010; 62 (10): 641-651. I-DOI: 10.1007 / s00251-010-0465-9.