Isifo se-Celiac yisimo sezakhi zofuzo, okusho ukuthi udinga ukuthi ube nama-gene "okulungile" ukuyihlakulela futhi utholakale nawo. I-HLA-DQ2 ingenye yezinhlobo ezimbili zesifo esiyinkimbinkimbi ye-celiac, futhi iyenzeka ukuthi iyisisindo esivame kakhulu esithinta isifo se-celiac (i-HLA-DQ8 enye enye okuthiwa "igazi leliliac").
Odokotela abaningi bakholelwa ukuthi udinga okungenani ikhophi eyodwa ye-HLA-DQ2 noma i-HLA-DQ8 ukuthuthukisa isifo se-celiac.
I-Celiac Genetics Basics
I-Genetics ingaba yisifundo esididekayo, futhi izakhi zofuzo ze-celiac zidideka ngokukhethekile. Nansi incazelo elula elula.
Wonke umuntu unamajethi we-HLA-DQ. Eqinisweni, wonke umuntu uzuza i-kopi emibili yamagciwane we-HLA-DQ - owodwa kusuka kumama wabo nenye evela koyise. Kunezinhlobonhlobo eziningi zezinhlayiya ze-HLA-DQ, kufaka phakathi i-HLA-DQ2, i- HLA-DQ8 , i- HLA-DQ7 , i-HLA-DQ9 ne- HLA-DQ1 .
Yi-variants ye-HLA-DQ2 ne-HLA-DQ8 ephakamisa ingozi yokuba nesifo se-celiac.
Njengoba wonke umuntu athola amajethi amabili e-HLA-DQ (owodwa kumzali ngamunye), kungenzeka ukuthi umuntu abe nekhophi eyodwa ye-HLA-DQ2 (ngokuvamile ebhaliwe njenge-HLA-DQ2 heterozygous), amakhophi amabili e-HLA-DQ2 (HLA-DQ2 ayenama-homozygous) , noma akukho amakhophi we-HLA-DQ2 (HLA-DQ2 okungalungile).
Ngaphezu kwalokho, kunenani izinguqulo ezintathu ezihlukile zegciwane le-HLA-DQ2. Omunye, owaziwa ngokuthi yi-HLA-DQ2.5, unikeza ingozi enkulu kwisifo se-celiac; cishe abahlali baseCaucasia abangaba ngu-13% base-US baphatha lesi sakhi sofuzo.
Kodwa-ke, abantu abanezinye izinguqulo ze-HLA-DQ2 nabo basengcupheni yesifo se-celiac.
Uma NgineGene, Iyini Ingozi Yami?
Lokho kuxhomeke.
Abantu abanamakhophi amabili e-HLA-DQ2 (iphesenti elincane kakhulu labantu) banomthelela omkhulu kunawo wonke wesifo se-celiac. Ngokwengqikithi yengozi yempahla esekelwe ucwaningo olushicilelwe olwenziwe yi-MyCeliacID yesevisi yokuhlola i-genetic, isifo se-celiac senziwa kubantu abanezimoto ezimbili ze-DQ2 ngezinga elizungeze izikhathi ezingu-31 zomphakathi jikelele.
Abantu abanamakhophi amabili e-HLA-DQ2 nabo banomngcipheko okwenyuka okungenani oyedwa uhlobo lwesifo se- celiac esicabangelayo (esenzeka lapho ukudla okungekho gluten kubonakala kungasebenzi ukulawula isimo), kanye ne -T ehambisana ne- enteropathy -cell lymphoma , uhlobo lomdlavuza oluhlobene nesifo se-celiac.
Abantu abanekhophi eyodwa ye-HLA-DQ2 banezikhathi ezingaba ngu-10 "ingozi evamile" yesifo se-celiac, ngokusho kwe-MyCeliacID. Labo abathwala kokubili i-HLA-DQ2 ne-HLA-DQ8, enye isifo se-celiac geni, banezikhathi ezingaba ngu-14 "ingozi evamile" yabantu.
Ezinye izinto zibandakanya
Akuwona wonke umuntu ophethe i-HLA-DQ2 okhulisa isifo se-celiac - isakhi sezitholakale ezingaphezu kuka-30% wabantu base-US (ikakhulukazi labo abanamagugu asezindaweni ezisenyakatho ye-European genetic heritage), kodwa kuphela ama-1% aseMelika anesifo se-celiac.
Abacwaningi bakholelwa ukuthi kunezinye izakhi zofuzo eziningi ezihilelekile ekunqumeni ukuthi ngabe umuntu obhekene nesifo sofuzo empeleni ukhulisa lesi simo, kodwa angakaboni zonke izakhi zofuzo ezihilelekile.
Imithombo:
Al-Toma A. et al. I-Human Leukocyte Antigen-DQ2 Homozygosity kanye Nokuthuthukiswa Kwezifo Ezibhekene Nezifo Ezibucayi Ne-Enteropathy- Ehlanganisiwe ne-T-Cell Lymphoma. I-Gastroenterology Clinic ne-Hepatology. 2006 Mar; 4 (3): 315-9.
Ithebula le-Risk Stratification le-MyCeliacID. Ifinyelele ngo-Mashi 20, 2012.
UPloski R. et al. Ku-HLA-DQ (i-alpha 1 * 0501, ukubhekwa kwe-beta 1 * 0201) -kuhlanganisiwe okuhlobene nesifo se-celiac: umphumela wokulinganisa i-DQB1 * 0201. Ama-Antigens we-Tissue. 1993 Apr; 41 (4): 173-7.
UVader W. et al. I-HLA-DQ2 umthamo wegciwane lesifo somzimba we-celiac uhlobene ngokuqondile nobukhulu nobubanzi bezimpendulo ze-T cell. Izinqubo ze-National Academy of Sciences. 2003 Okthoba 14; I-100 (21): 12390-12395.