Isakhi se-HLA-DQ7 asithathwa njengesinye sezakhi zofuzo eziyinhloko ezingakunqanda kwisifo se-celiac . Kodwa kunobunye ubufakazi bokuthi kungase kudlale indima esimweni, futhi mhlawumbe ekuzweleni kwe-gluten okungenayo i -celiac.
Isifo se-Celiac yisimo esisekelwe ngokobuciko, okusho ukuthi udinga ukuthi ube nama-gene "okulungile" ukuyihlakulela. Abacwaningi bathole ukuthi izakhi zofuzo zakho ze-HLA-DQ zibonakala zidlala indima ebalulekile ekuhlaseleni okuphazamisayo -isici esiwumonakalo emathunjini esitholakala esibhedlela se-celiac.
I-HLA-DQ Genes nesifo se-Celiac
Beka nami: lokhu kuyinkimbinkimbi futhi kudideka.
Wonke umuntu uzuza ifulegi ezimbili ze-HLA-DQ ezivela kubazali bazo-uthola eyodwa kusuka kumama wakho nenye evela koyihlo.
Kunezinhlobonhlobo eziningi zezinhlayiya ze-HLA-DQ, kufaka phakathi i-HLA-DQ7, i- HLA-DQ2 , i- HLA-DQ8 , i-HLA-DQ9 ne- HLA-DQ1 . Ungase uzuze izakhi zofuzo ezimbili ze-HLA-DQ ezihlukene (isimo esivame kakhulu), noma umthamo ophindwe kabili wegciwane elithile le-HLA-DQ (isimo esingavamile kakhulu).
Kuzo zonke izinhlobo ezahlukene zezakhi zofuzo ze-HLA-DQ, kunezinhlobo ezimbili okuthiwa " izifo zesifo se-celiac :" HLA-DQ2 kanye ne-HLA-DQ8 encane. Abantu abaningi abahlakulela isifo se-celiac bane-HLA-DQ2, kuyilapho amaphesenti amancani kakhulu ene-HLA-DQ8. Lezi zakhi zofuzo ezimbili zibonakala ziphendula cishe ngamaphesenti angu-96 kuwo wonke umuntu otholakala enesifo se-celiac.
Indlela i-HLA-DQ7 ifinyelela ngayo
Kukhona abanye abantu abangathwali i-HLA-DQ2 noma i-HLA-DQ8 futhi abasakhula isifo se-celiac.
Okungenani isifundo esisodwa sitholile ukuthi cishe ingxenye yalaba bantu (ngamanye amazwi, cishe 2% wabantu abanesifo se-celiac) empeleni baphathe i-HLA-DQ7.
Lokhu kubonisa ukuthi i-HLA-DQ7 ingaba isisindo esingakwazi ukubeka abanye abantu esimweni.
Noma kunjalo, lo mbono awusandelwanga kwezinye izifundo, futhi ucwaningo olwengeziwe luyadingeka ukuze kutholakale ukuthi i-HLA-DQ7-efana ne-HLA-DQ8-ngempela ingaholela esibhedlela se-celiac, noma ngabe awunayo kulabo "abakhulu" izifo zesifo se-celiac. Ngalesi sikhathi, odokotela abaningi abacabangi ukuthi i-HLA-DQ7 ibe isifo sofuzo se-celiac.
Kungenzeka futhi ukuthi i-HLA-DQ7 idlala indima ebuthakathakeni obungenayo i-celiac ye-gluten, isimo esicatshangwa ukuthi asifani nesifo se-celiac (nakuba izimpawu ze-gluten zokuzwela zifana nezibonakaliso zesifo se-celiac ).
UDkt. Kenneth Fine, owasungula indlela yokuhlola ukuzwela kwe - gluten esetshenziswe ku- Enterolab (isevisi ngqo kuya kubathengi), uqoqe idatha yegciwane le-HLA-DQ kuziguli eziningi ze-Enterolab. Uphelile, ngokusekelwe ocwaningweni lwakhe olungashicilelwe, ukuthi i-HLA-DQ7 ibeka phambili ekunakekeleni ukuzwela. Noma kunjalo, imithi ejwayelekile ngokuvamile iphuza lo cwaningo ngoba ayikashicilelwa futhi ihlolwe.
Konke okuqinisekile ukuthi kunezakhi eziningi zegciwane ezihilelekile ekuthuthukiseni isifo se-celiac, kodwa abacwaningi abakasazibona zonke. Ukucwaninga kokuzwela kwe-gluten kuqale nje, futhi ososayensi abazange baqume ukuthi ngabe yisimo esisekelwe ngokwezakhi zofuzo.
Imithombo:
Sacchetti L. et al. Ukubandlulula phakathi kwezimo ezibucayi ze-Celiac nezinye zezinsizwa ebuntwaneni nge-Rapid Human Lymphocyte Typing Typing. I-Chemistry Clinical. Agasti 1998, Umq. 44, No. 8, k. 1755-1757.
I-University of Maryland Centre for Research Celiac fact sheet. Izifo ze-Celiac Imibuzo Ebuzwa Ngokujwayelekile.