Ukungena-gluten-mahhala kungenzeka ukuthi okwamanje kungabi yisici
Njengoba kutholakala ukuvivinya kwezidakamizwa ezithuthukisiwe, odokotela manje kunanini ngaphambili bakwazi ukubona izifo ze-chromosomal ngokuqondile noma ngokungaqondile kuxhunywe nesifo. Enye yalezi zifo eziyi- celiac .
Ngokungafani neminye imibandela lapho umphumela omuhle uhambelana ngokuqondile nezibonakaliso zesifo, umphumela omuhle wokuhlolwa kofuzo lwe- celiac ukhombisa amathuba-kunokuba aqiniseke-ngesifo.
Ezimweni eziningi, amathuba azoba amancane.
Ukuqaphela i-Genetic Celiac
Izinguquko ezimbili ze-chromosomal, ezaziwa njenge- HLA-DQ2 ne- HLA-DQ8 , zivame ukuhlotshaniswa nesifo se-celiac.
Ngencazelo, i-HLA (i-leukocyte antigen yomuntu) iyi-protein yamaselula edala ukuphendula komzimba. Ngesifo se-celiac, ukuphazamiseka kwe-HLA ukufaka ikhodi kungenza ukuba isimiso somzimba sokuzivikela singene haywire phambi kwe-gluten nokuhlasela amangqamuzana emathumbu amancane .
Naphezu kokuthi i-HLA-DQ2 ne-HLA-DQ8 bobabili bahlanganiswe nalomphumela, ukuguqulwa komzimba akusho ukuthi uzothola lesi sifo. Eqinisweni, abantu abangamaphesenti angama-40 abantu base-United States banezakhi zinguquko, ikakhulukazi kubantu baseYurophu.
Kulabo abathwala ukuguqulwa komzimba, kuphela amaphesenti ayisishiyagalolunye kuya kwamaphesenti amane azoqhubeka nokuthuthukisa lesi sifo eminyakeni yabo emdala. Konke okukhulunywe ngakho, cishe abantu abangu-100 base-US bayothola isifo se-celiac ngesimo esisodwa noma esinye ngesimpawu esivela esiyinkimbinkimbi kuya cishe engekho .
Kwenzekani Uma Uhlola Okuhle
Ukuhlolwa okuhle kwe-HLA-DQ2 noma i-HLA-DQ8 akusho ukuthi kufanele ushintshe imikhuba yakho yokudla ngaphandle kokuba unezibonakaliso zesifo (kufaka phakathi umonakalo we-villi obeka emathunjini amancane). Ukuhlolwa kuzokutshela ukuthi unesisindo se-sifo, akukho lutho.
Ngalokho kuthiwa, ochwepheshe abaningi be-celiac bazokwazisa wena nomndeni wakho ukuba uhlolwe njalo lapho kwenzeka ukuthi eyodwa noma ngaphezulu kwakho ekugcineni ibe uphawu.
Lokhu kungenxa yokuthi ukuguqulwa kwe-HLA kudluliselwa kumzali kuya komntwana, kanti ezinye izingane zizuze amakhophi amabili okuguqulwa (okuvela kumzali ngamunye) ngenkathi abanye bebodwa kuphela. Ngokusobala, labo abazuza ifa elibili babesengozini enkulu.
Ngakolunye uhlangothi, uma unayo izimpawu nazo zonke ezinye iziphumo zokuhlolwa zingalungile, ukuhlola okuhle kwe-HLA kungase kulungise isikhathi sokulinda lapho uvimba khona i-gluten ukuze ubone ukuthi izimpawu zakho ziyathuthuka.
Izwi elivela
Abantu abasolwa ukuthi banesifo se-celiac bavame ukuqala ukudla okungenalutho kwe-gluten ukuze babone uma isimo sabo sithuthuka. Nakuba lokhu kuhle kakhulu futhi ngeke kubangele noma yikuphi ukulimala, ukuqala kwangaphambili kungalimaza ikhono lakho lokuthola i-diagnostic enembile uma unquma ukuhlolwa.
Lokhu kungenxa yokuthi iphaneli legazi le-celiac elijwayelekile lizobheka ama-antibodies ethize ukuba agwebe egazini lakho, kanti ukuhlolwa kokuphela kwesikhathi kuzosesha ubufakazi obonakalayo bomonakalo emathunjini amancane. Ngaphandle kokuba kutholakale i-gluten, ukuhlolwa akukwazi ukukhomba izici zesifo futhi kungaqeda ukubuyisela umphumela omubi wamanga .
Uma ufuna ukuxilongwa okunembile, kumele uvezwe ku-gluten. Ukuhlolwa kofuzo kungasikisela kuphela ukuthi kungenzeka yini isifo kunokunikeza ukuxilongwa okucacile.
> Umthombo:
> Wessels, M .; Vriezinga, S .; UKoletzko, S. et al. "Impumelelo kubazali be-genotyping ye-HLA-DQ2 / DQ8 ezingane ezinempilo ezivela emindenini yama-celiac." I-Eur J Hum Genet. 2015; 23, 405-88. I-DOI: 10.1038 / ejhg.2014.113.