Eyaziwa ngokujwayelekile ngokuthi i-linaclotide, le mithi iphumelela ku-IBS-C no-CIC
Ukuqothulwa kungaba lula ukuhleka usulu, kodwa ngokungaqiniseki ukudlulela kahle ukuhamba komzimba akuyona into ehlekayo. Futhi nakuba kunezimbangela eziningi ezingabangela ukuzunywa (ukudla i-fiber encane kakhulu, ukuthatha imithi ethile, ukuhlinzwa okwamanje), ezimweni eziningi isimo sesikhashana futhi kulula ukubhekana nokuguqula ukudla, ukuqeqeshwa okwengeziwe, noma ukuthatha -the-counter laxatives noma izithambile zokunciphisa.
Kodwa kwabanye abantu, ukuqothulwa kungaba yinkinga enkulu-okudinga ukwelashwa okunamandla. Yilapho imithi yokwelashwa i-Linzess (i-linofftide) ingena. (EYurophu, i-linoclotide ithengiswa ngaphansi kwegama elithi Costella.) Lisetshenziselwa ukuphatha abantu abane-subtype ye-bowel syndrome ecasulayo (IBS) abanokuqothulwa kanye nobuhlungu besisu, ama-cramps , nokubhuqa. Kuvame ukubizwa ngokuthi ukuqothulwa-isifo esiyingozi kakhulu esiswini (IBS-C).
I-Linzess nayo isetshenziselwa ukwelapha ukuxilongwa okungapheli kwe-idiopathic (i-CIC), okuyinto iZiko Likazwelonke Zempilo elichaza ngokuthi "ukuhamba okunzima noma okungavamile kwezihlalo ezithatha izinyanga ezintathu noma ngaphezulu ngaphandle kwesizathu esibonakalayo sezokwelapha zesimo."
Uma ubhekene ne-IBS-C noma i-CIC futhi udokotela wakho ubeka i-Linzess kuwe, yilokho okudingayo ukwazi ukuthi isidakamizwa sisiza kanjani ukukhulula ukuqotshwa nokuningi.
Indlela i-Linzess isebenza ngayo
I-Linzess ibhekwa njenge "peptide agonist yama-guanylate-cyclase-C receptors." Lokhu kusho ukuthi imithi ivuselela amangqamuzana athile e-receptor ngaphakathi kwendlela yokugaya ukuze ukwandise ukugeleza kohlobo lwamanzi emathunjini.
Lesi sinyathelo kucatshangwa ukuthi siphuthumise izinga lapho ikontoni ivumelana khona futhi ukunciphisa inani lobuhlungu umuntu azizwa ngaphakathi kwesisu nesisu sokugaya, okwaziwa ngokuthi "i- visceral hypersensitivity ." Ngenxa yokuthi iLinzess ikholelwa ukuthi isebenza "endaweni yangakini," ngaphakathi emathunjini amancane namakhulu, kunengozi encane kuyokwenza imiphumela emibi engadingekile, njengesifo sohudo esincane.
Ingabe Iphumelela?
Ucwaningo lubonisa ukuthi i-Linzess isebenza kahle. Isibonelo, ezimfundweni zomtholampilo, uma kuqhathaniswa nabantu abathwala i-placebo, labo abathatha i-Linzess cishe banokuzwa:
- Ukwanda kwenani lezimpawu zokuhamba
- Ukwenza ngcono kwesimo se-stool
- Ukunciphisa kancane
- Ubuhlungu obungaphansi kwesisu nokungahambi kahle
- Nciphisa ekubhubheni
Ngaphezu kwalokho, izidakamizwa zisebenza masinyane uma umuntu eqala ukuthatha, futhi usebenza kahle uma nje ekhona.
Indlela Yokuthatha Linzess
I-Linzess iza njenge-capsule. Kulula ukuthatha: Sula yonke i-capsule (ungayiqedi, isibonelo, ngoba lokhu kuzothinta izinga lapho umzimba wakho uyithatha khona) futhi ngaphandle kokuthi udokotela wakho akutshele ngenye indlela, thatha ngesikhathi esisodwa nsuku zonke , esithombeni esingenalutho, kungaphansi kwesigamu sehora ngaphambi kokudla kokuqala kosuku. Ngakho-ke, uma udla isidlo sasekuseni ngo-8 ekuseni, thatha i-Linzess capsule ngaphambi kuka-7: 30.
Ukuqapha okunye: Ngisho noma i-Linzess imithi ephephile futhi ephumelelayo kubantu abaningi, kungase kungabi umbono omuhle kwabesifazane abakhulelwe noma ababeletha ingane ukuba bayithathe. Qinisekisa ukuthi udokotela wakho uyazi uma ulindele noma uncelisa uma ethi ufuna ukubeka i-Linzess kuwe. Uma kungenjalo, yazi ukuthi uma uqala ukuthatha lesi sidakamizwa, ungaqala ukuzizwa ungcono phakathi nesonto noma kunjalo.
> Imithombo:
I-Ford, A., etal. "I- American College of Gastroenterology Monograph ekuphathweni kwe-Irritable Bowel Syndrome ne-Chronic Idiopathic Constipation " I- American Journal of Gastroenterology 2014 109: S2-S26.
Gaman, A., Bucur, M. & Kuo, B. Ukuthuthukiswa kwezinsizakalo ezenzweni zesisu zomzimba ezinomzimba: ukucasula isifo sofuba isifo sofuba Ukuthuthukiswa kwezifo ku-Gastroenterology 2009 2: 169-181.
Lee, N. & Wald, A. "I-Linaclotide: ubufakazi bokusetshenziswa kwayo okungahle kusetshenziswe isifo sofuba nesifo esingenasifo esibuhlungu" Ubufakazi obuningi 2012 7: 39-47.
I-Maneerattanaporn, M., Chang, L., & Chey, W. "Imithi Ephuthumayo Yezokwelapha Ze-Irritable Bowel Syndrome" Imitholampilo Ye-Gastroenterology eNyakatho Melika 2011 40: 22-243.