I-Prucalopride imithi eyenzelwe ukwelapha ukuqotshwa okungapheli - inkinga yezempilo evezwe yindawo engapheliyo futhi enzima yezihlalo ezinde isikhathi eside, kanye nezinye izinkinga ezicindezelayo ezifana nokuqeda kwesisu, ukuphuza isisu, nokuhlanza. Izinketho zokwelapha zendabuko zokuqotshwa okungapheli zibandakanya kakhulu ukuguquka nokuguquka kokuphila kanye / noma ukushiswa kwamakhemikhali.
I-Prucalopride okwamanje itholakala kuphela eYurophu, ngaphansi kwegama elithi brand "Resolor" naseCanada njenge "Resotran". I-European Medicines Agency (EMA) iye yavuma ukusetshenziswa kwe-prucalopride (Resolor) kuphela yokwelapha ukuqashwa okungapheli kwabesifazane abangazange basabele ekusebenziseni amakhemikhali . Izifundo zenziwa ukuze zithole imvume ngokusebenzisa i-EMA ukuze kusetshenziswe i-prucalopride emadodeni ahlupheka ngokuqashwa okungapheli.
I-Prucalopride Isebenza Kanjani?
I-Prucalopride ibonakala njenge-agonist engu-5-HT4. Lokhu kusho ukuthi kusebenze ama-receptors ama-5-HT4 we-serotonin ye-neurotransmitter. Lokhu kusebenza kucatshangwa ukuthi kwandise isimiso somzimba wamathumbu ngokukhula kwe-peristalsis, noma ukunyakaza kwemisipha emathunjini okhipha isisu emzimbeni, okwenza izihlalo zibe lula ukudlula futhi kubangele ukunyakaza okuphindaphindiwe kwamathumbu.
I-Prucalopride ingamakilasi afanayo emithi njengoZelnorm.
Kodwa-ke, i-prucalopride iklanyelwe ukuba ibe nesenzo esihlukile emzimbeni ukuze kuncishiswe amathuba okubonakaliswa okungavamile kepha okubi kakhulu okubangelwa yisifo senhliziyo okuholela kuZelnorm ukukhishwa emakethe.
Indlela Ephumelela Ngayo I-Prucalopride Ekuphatheni Ukuqothula Okungapheli?
Ezilingo zomtholampilo kuze kube yimanje, i-prucalopride iboniswe ukuthi iphakeme kune- placebo kulezi zindawo ezilandelayo:
- Ukwandisa imvamisa yokunyakaza okuzenzekelayo nokuphelelisa.
- Ukwenza ngcono ukuqonda kwesineke kwekhwalithi yokuphila.
- Ukuthola ekubonweni kwesiguli ukuthi ukuqotshwa akuyona inkinga encane.
Yimiphi imiphumela emibi yePrucalopride?
Ezicwaningweni kuze kube manje, imiphumela emibi elandelayo ibe nayo:
Ingabe Usizo lwe-Prucalopide IBS?
Ekubuyekezeni kwayo kwamuva kocwaningo, i-American College of Gastroenterology iphetha ngokuthi ucwaningo lusekela ukuphumelela kwe-prucalopride kokubili ukuqashwa okungapheli kanye ne-IBS-C. Abacwaningi be-ACG baqaphele ukuthi i-prucolopride ayithwali izingozi zikaZelnorm zezenzakalo ezinkulu zenhliziyo.
Ubani Okungafanele Athathe I-Prucalopide?
Abantu abathile basengozini enkulu yokuthuthukisa imiphumela emibi noma imiphumela ebuhlungu ekuthathweni kwe-prucalopride. Lezi zihlanganisa abantu:
- I-hypersensitivity eyaziwayo kumuthi noma noma yiziphi izithako zayo
- Ukukhubazeka okunomsoco okudinga i-dialysis
- Ukuphazamiseka kwamathumbu emathunjini noma ukuvinjelwa
- Ileus yokuvimbela
- Izimo ezivuthayo zokuvuvukala komuthi wamathumbu
- Izifo ezithinta izifo ezinomsoco ezingokomzimba, ikakhulukazi ama-arrhythmias noma ischemic isifo senhliziyo.
Imithombo:
I-Ford, A., etal. "I- American College of Gastroenterology Monograph ekuphathweni kwe-Irritable Bowel Syndrome ne-Chronic Idiopathic Constipation " I- American Journal of Gastroenterology 2014 109: S2-S26.
I-Ford, A. & Suares, N. "Umphumela wama-laxatives kanye nemithi yokwelapha ekuziqhenyweni okungapheli kwe-idiopathic: ukubuyekezwa okuhlelekile nokuhlaziywa kwe-meta" Gut 2011: 60: 209-218.
I-Maneerattanaporn, M., Chang, L., & Chey, W. "Imithi Ephuthumayo Yezokwelapha Ze-Irritable Bowel Syndrome" Imitholampilo Ye-Gastroenterology eNyakatho Melika 2011 40: 22-243.
"I-Movetis iqala isilingo sesiguli se-Phase III nge-prucalopride ezigulini zesilisa ezinokuqokwa okungapheli" UMovicesis NV Press Release, September 24, 2010.
"Ukuxazulula" I- European Medicines Agency yafinyelela ku-Mashi 17, 2011.
Quigley, E. "Prucalopride: ukuphepha, ukusebenza kanye nezinhlelo zokusebenza ezingase zibe khona Ukuthuthukiswa kwezinkinga ku-Gastroenterology 2012 5: 23-30.