Izinselelo zokwelapha uhlobo olungavamile lomdlavuza wekoloni
Umdlavuza we-Colorectal igama elisetshenziselwa ukuchaza izinhlobo eziningi zokuhlukunyezwa komdlavuza okuthinta ikoloni kanye / noma i-rectum.
Kulezi zinhlobonhlobo , kukhona enye ebonakala sengathi ifomu eliyinhloko elichaphazela abantu abangaphezu kuka-125 000 baseMelika ngonyaka. Ibizwa ngokuthi i-adenocarcinoma nama-akhawunti amaphesenti angama-95 azo zonke izinhlobo zomdlavuza we-colorectal e-US Ngokungeziwe ku-adenocarcinoma ye-classic (AC), kukhona ama-subtypes amabili ajwayelekile awaziwa ngokuthi:
- i-mucinous adenocarcinoma (i-MAC)
- i-signet-ring cell carcinoma (i-SRCC)
Kulawa ma-subtypes, i-MAC ibonakala njalo futhi ibhalwa ngamaphesenti angu-10 no-15 kuwo wonke ama-cancer angama-colorectal.
Ukuqonda i-Adenocarcinoma
I-Adenocarcinoma ibhekisela ngqo kumagciwane angathinta amangqamuzana anomvelo obumnyama. "I-Adeno-" yisiqalo noma "gland" kanti "i-carcinoma" yigama elisetshenziselwa ukuchaza amakhemikhali aqala esikhumbeni noma emathisini afaka izitho.
I-Adenocarcinomas ithuthuka ngoba ikholoni yenziwe inethiwekhi enkulu yezinhlayiya ezikhonza imisebenzi emibili ebalulekile:
- ukuthola amanzi emanzini abuyele egazini
- ukufaka isikhala emgodini ukuze ubhontshe izidakamizwa njengoba bexoshwa emzimbeni
Uma lawa maseli engakwazi ukukhiqiza i-mucus egcwele, ubunikazi bekolon lungonakaliswa njengezikhuni ezingabonakali futhi uzilimaze. Ngokuhamba kwesikhathi, lokhu kungabangela umonakalo ezingeni lezakhi zofuzo, okwenza amangqamuzana aphindwe ngokungavamile ngaphandle kwanoma iyiphi indlela yokuvimbela noma ukuphindaphindiwe.
Yilokho okubangela ukubunjwa kwe-adenocarcinoma.
Yeka indlela i-Adenocarcinoma enobuthi ehluke ngayo
I-adenocarcinoma emnandi (i-MAC) ihluke ku-adenocarcinoma (AC) njengoba kungenzeka ukuthi ivela ezifweni ezifanayo zofuzo kodwa, esikhundleni sokukhiqiza i-mucus encane, iveza okuningi.
I-MAC ibonakala ngokubunjwa kwe-tumor okungenani ama-50% we-mucin.
I-Mucin ayiyona inambuzane ngayinye kodwa kunalokho i-glycoprotein ingxenye ye-mucus nezinye izikhukhula zomzimba (njengamathe kanye nobisi lwebele). Yilokho okuyingxenye ye-mucinous ukuthi abaningi bakholelwa ukuthi kusiza isisu sikwazi ukusabalalisa kakhulu njengoba sibheka ngaphesheya kwezindonga zesisu kuya ezicubu eziseduze.
Ngenxa yalokho, i-MAC sekuye kwacatshangwa ukuthi ifomu le-AC enobudlova futhi ingaba ukwelashwa okuncane kakhulu. Zombili lezi zinkolelo ziphikisana kakhulu phakathi kwabacwaningi, abanye babo abaxoshwa ukuthi akusiyo ijubane lentuthuko kodwa kunesiteji lapho kutholakala isisu esiholela emiphumeleni empofu.
Kukhona ubufakazi bokusekela lokhu. Ngokuvamile, i-MAC itholakale ngezigaba ezithuthukisiwe zesifo. Lokhu kungenxa yokuthi, ngokwengxenye, ukuthi izicubu ze-mucinous zinezinga elide kakhulu lokuthi izicubu "ezijwayelekile" futhi azivame ukutholakala kuze kube yilapho zikhudlwana futhi zizwakala kakhulu.
Ngisho nalapho kutholakala kusenesikhathi, ukuma nesimo esingenalutho emzimbeni kwenza kube nzima ngisho nakubantu abanokuhlangenwe nakho kwempilo ukuthi bafunde kahle .
Ngakolunye uhlangothi, i-MAC inesignesha "isignesha" ngokuphelele kune-AC. Ngenkathi singakakwazi ukuthi lokhu kuhlobene kanjani nokukhula kwesifo - kungenzeka noma cha - siyazi ukuthi umdlavuza we-mucinous uvame ukuba ngaphansi kokusimama kwezakhi zofuzo (isimo esibhekisela ekusimeni kwe-microsatellite ) kunomdlavuza ongenawo umuthi.
Lezi zifo ezincane zibangelwa ukukhiqiza ngokweqile noma i-mucin. I-mucin, futhi, yakha umgoqo okungase, empeleni, uvimbele imithi yokwelapha i-chemotherapy kusuka emangqamuzaneni asemdlavuza aphumelelayo. Ngamafuphi, i-chemo ingase ingakwazi ukuthola ukuthi idinga kuphi.
Izwi elivela
Nakuba kucacile ukuthi i-adenocarcinoma ye-mucinous inezici ezihlukile ezenza kube nzima ukuthola ukuhlolwa (futhi kungaholela esikhathini esifushane sokusinda), kunezici esazi ukuthi zihlobene eduze nentuthuko yayo:
- ubudala
- ngokuba owesifazane
- umlando wezifo ezibangelwa ukuvuvukala (IBD), njenge-Crohn's disease noma i-ulcerative colitis
- umlando we-radivic or radiation therapy
Uma kunezibonakaliso zokuqala zomdlavuza wombala futhi unomlando womndeni wesifo, kubalulekile ukuthatha izinyathelo ezingeziwe uma uphenyo lungakapheli. I-MAC ivame ukuphoqeka kalula ngesikhathi se-biopsy futhi ingahle ibonakale kalula ngokusebenzisa i- imagery resonance imaging (MRI) .
Unganqikazi ukucela uphenyo olwengeziwe uma izimpawu ziqhubeka noma zimbi nakakhulu. Ngenye indlela, ungafuna umbono wesibili kumchwepheshe obala owaziwa yi-MAC no-SRCC.
> Imithombo
- > National Cancer Institute: Izikhungo Zikazwelonke Zempilo. "I-Cancer Stat Facts: I-Colon ne-Rectum Cancer." I-Bethesda, e-Maryland; 2017.
- > Numata, M .; Shiozawa, M .; I-Watanabe, T .; et al. "Izici ezivela emitholampilo ye-colorectal mucinous adenocarcinoma kanye nesimiso sokulwela lesi sifo." I-World Journal of Oncology Yokuhlinza. 2012; 10: DOI: 10.1186 / 1477-7819-10-109.