Esinye sezici eziyingqayizivele yomdlavuza wesi-prostate ukuphendula kwayo ekuhoxisweni kwe- testosterone . Le "Achilles Heel" yesifo somdlavuza we-prostate itholakale ngawo-1940 lapho kukhishwa ukwelashwa kwezicathulo ukuze kukhishwe imishanguzo yomdlavuza. Ngo-1985, i-Lupron, imishanguzo ejoqayo eyafeza into efanayo yavunyelwa yi-FDA.
I-Lupron isebenza ngokukhohlisa amathemikhali ukuvala ukukhiqizwa kwe testosterone.
Ukuphumelela
I-Lupron ilawula umdlavuza wesifo sofuba ngokweminyaka ephakathi kweminyaka emibili kuya kweyisithupha kumadoda anesifo se-metastatic, futhi iminyaka engaphezu kwengu-10 lapho ukwelashwa kuqala ngaphambi kokuba isifo se-metastatic sitholakale ngokuskena. Lapho uLupron eyeka ukusebenza, amanye ama-hormonal efana neCasodex noma iNilandron anganikeza ukulawula okwesikhashana, kodwa isikhathi sabo sokusebenza (ukugcina i-PSA phansi) kuvame ukuhlala ngaphansi konyaka.
Ukuphikisana kuye kwaqhuma emfundweni yokuthi ukwehla okulula kumazinga e- PSA kubonisa ngokunembile ukuthi ukusinda kwesiguli kuyodluliselwa. Ngakho-ke lezi zinsuku, i-FDA izovuma kuphela isidakamizwa esisha uma amadokhumenti womkhiqizi wezokwelapha ethuthukisa ukuqhubeka nokuhlolwa kweso lengqondo elilawulwa yi-placebo. Ukuqinisekisa ukusinda okuthuthukisiwe kuyinselelo enkulu kunokuba nje kubonise ukuthi imithi ibangela ukwehla okwesikhashana emazingeni e-PSA.
I-Zytiga (i-abiraterone) eyayifundwa emadodeni anezifo zemetastatic esebenze ukumelana noLupron yabonisa lezi zisebenzi zokuvolontiya ezine-metastatic, i-Lupron-resistant-resistant prostate umdlavuza owathola i-abiraterone yaboniswa ukuthi aphile iminyaka engu-33% kunamadoda athola indawo ye-placebo.
U-Zytiga ungumuthi wemiklamo osebenza ngokuxhaphaza ukutholakala okusheshayo ukuthi ukuphikisana noLupron (okuchazwa ngokuthi umdlavuza ukukhula naphezu kwesifo se-testosterone egazini) akuwona umphumela wamangqamuzana omdlavuza afunde ukukhula ngaphandle kwe-testosterone.
Kunalokho, ukumelana ne-Lupron kubangelwa amangqamuzana omdlavuza we-prostate esefunde indlela yokukhiqiza u-testosterone wabo ngaphakathi.
Impumelelo yayo yokuzibulala isebenza ngokuvimbela i-enzyme ebalulekile ephakathi kwesikhumba somdlavuza, i-enzyme engxenyeni ebalulekile endleleni yokwenziwa kwe testosterone. Umphumela wenetha wukuthi iseli lomdlavuza uvinjelwe ekukhiqizeni u-testosterone wayo.
Okuqhamuka uma udla imishanguzo
Imiphumela emibi ye-Zytiga ingafaka izinguquko emazingeni e-potassium egazini, futhi ezimweni ezingavamile, ukungasebenzi kwesibindi. I-Zytiga iphinde ithuthukise isenzo sepilisi ye-cholesterol efana ne-Lipitor ne-Crestor ngakho umthamo wabo udinga ukunciphisa ukukhokhela.
Ukugcina amazinga e-potassium ku-range evamile iZytiga ilawulwa ngokuhlanganyela ne- prednisone , uhlobo lwe-cortisone. I-Cortisone ingaba nemiphumela emibi futhi. Ngezinye izikhathi kuhlotshaniswa nokucasula esiswini kanye nezilonda zesisu. Amazinga ashukela ephezulu aphezulu angatholakala nakwabantu abanesifo sikashukela.