Imiphumela yesikhuphukako isanda ku-tandem nesikhathi sokusebenzisa
I-Prednisone iyisidakamizwa esinamandla kakhulu se- corticosteroid esetshenziselwa ukuphatha izinhlobo zokuvuvukala kwe-arthritis kanye nezinye izinhlobo zomdlavuza kanye nesifo esizimele . Itholakala kuthebhulethi kanye nokwakhiwa kwamakhemikhali kanye nemisebenzi njenge- immunosuppressant , ukuvuvukala ukufutheka ngokuphazamisa impendulo yomzimba.
Indlela i-Prednisone isebenza ngayo
Ukuvuvukala impendulo yemvelo yomzimba kunoma yini engacabanga ukuthi iyingozi.
Uma isimiso somzimba sokuzivikela ngculazi sibonisa i-agent eyingozi, ikhulula amakhemikhali egazini elidala izicubu ukuba zikhule, ngokwengxenye ukwandisa ubukhulu bemithanjeni yegazi futhi kuvumela ukuthi amangqamuzana omzimba omzimba amancane afinyelele esiteshini sokulimala noma ukutheleleka.
Ngezinye izifo ezizimele, impendulo yegciwane lengculazi ayijwayelekile futhi ikhululekile. Kunjalo nge- arthritis ye-rheumatoid (RA) lapho isimiso somzimba samasosha omzimba sizohlasela ngamalungu angempilo ngokungafanele. Izimpawu ze-RA ezivame ukuvutha ngaphandle kwesaziso, kubangela ubuhlungu obukhulu, ukuvuvukala, nokulimala kokuhlangene okuthintekile.
I-Prednisone inamandla okulawula lezi zithwala ngokushesha ngokunciphisa ukuvuvukala kwaze kwaba yilapho ezinye izidakamizwa zokulwa nezifo ezithathelwanayo (DMARD) zingasebenza. Ngesikhathi i-DMARD efana ne- Plaquenil (i-hydroxychloroquine) ne- Arava (i-leflunomide) ihloselwe kakhulu ekulawuleni amasosha omzimba, asebenza kancane kancane.
Ngokuphambene, i-prednisone iyashesha ekuhlinzekeni impumuzo kodwa inemiphumela emibi eminingi eyehlisa umgomo wayo, ikakhulukazi esikhathini eside.
Ngokungafani ne-DMARD, i-prednisone ayihlosi iseli ethize noma umsebenzi wezinto eziphilayo. Esikhundleni salokho, isebenza ngokuhlelekile, ikhukhumeza umzimba futhi ifaka izinhlobo eziningi ezahlukene zamaseli nemisebenzi. Kungenxa yalesi sizathu ukuthi i-prednisone ingahlinzeka ukukhululeka ngakolunye uhlangothi futhi ibangele izinkinga kwenye.
Okuqhamuka uma udla imishanguzo
Imithelela emibi ye-prednisone ingaba kusukela emnene kuze kube nzima.
Zenzeka ngokuphindaphindiwe ezinyangeni eziphakeme noma ngokusetshenziswa kwesikhathi eside.
Imiphumela emibi yesikhathi esifushane ifana nezinye izidakamizwa ze-corticosteroid futhi ingafaka ukugcinwa okunesisindo, ukukhushulwa kwesisu, nokwanda kweglucose yegazi.
Kodwa-ke, izinkinga ziphakama uma ukwelashwa kuqhubeka isikhathi eside, ukwanda ngamandla njengoba isikhathi noma umthamo ukwanda. Imiphumela emibi ingafaka:
- Umfutho wegazi ophezulu
- Ukukhathala okuqhubekayo
- Imodi iyashintsha, kuhlanganise nentukuthelo engazelelwe
- Ukulahlekelwa kokuhlushwa noma ukudideka
- Ukucindezeleka nokukhathazeka
- Ukungalali
- Inzuzo yesisindo
- Ukuvuvukala komzimba obukhulu
- Ukuya esikhathini okungavamile
- Isilonda se-Peptic
- Umbono ophukile, i- glaucoma , noma i- cataracts
- Ubuthakathaka besisindo kanye ne-atrophy
- Ukuthinta noma isikhumba
- Ukulimala kalula
- Ukwandisa ingozi yokutheleleka ngenxa yokunciphisa umzimba
- I-osteoporosis kanye nengozi eyengeziwe yokwehlukana
- I-bone ukufa (i- osteonecrosis )
- Izifo zesibindi ezinamafutha (i- hepatic steatosis )
- I-Psychosis
- Ukukhula okunamandla ezinganeni
Ukubeka imininingwane
I-Prednisone itholakale kokubili ukwakheka ngokushesha kokukhululwa nokulibala. Ukuze ukwelashwa kwe-RA kubantu abadala, lesi sidakamizwa sinqunywe kanje:
- I-prednisone yokukhululwa ngokushesha inqunywe kumthamo wansuku zonke wamagremu angaphansi kuka-10 ngosuku othathwe nge-DMARD.
- I-prednisone ekhishwe isikhathi esinqunyiwe inqunywe umthamo wansuku zonke wamamililogramu amahlanu ukuqala, ilandelwa umthamo wokugcina ongasetshenziswa kakhulu ukugcina umphumela omtholampilo omuhle.
I-Prednisone ivame ukuthathwa njengomthamo owodwa ngesikhathi sasekuseni ukuze kuvinjelwe kangcono isisu esiswini.
Kubantu abane-arthritis enesifo esibi kakhulu, ukubunjwa kokukhululwa okubambezeleka kungathathwa ngesikhathi sokulala ukuze kunciphise ukuqina kwesimanje nobuhlungu.
Isikhathi sokwelashwa kufanele senziwe ngesinye isinye, silinganise izinzuzo kanye nezingozi bese sinquma ukuthi ukwelashwa kwansuku zonke noma okuphakathi kungcono kakhulu.
Ukusebenzisana kwezidakamizwa
I-Prednisone yaziwa ukuthi inokuxhumana okuningi kwezidakamizwa nezidakamizwa. Kwezinye izimo, izidakamizwa zesibili zingandisa ukwanda kwe-prednisone futhi, kanye nayo, ubukhulu bemiphumela emibi.
Kwezinye izimo, i-prednisone ingaphazamisa umsebenzi wesidakamizwa sesibili.
Ukusebenzisana okwenziwe izidakamizwa-izidakamizwa kufaka:
- Ama-antibiotics afana ne-clarithromycin noma i-rifampin
- Ama-antidepressants afana ne-Zoloft (sertraline) ne-Prozac (i-fluoxetine)
- Izidakamizwa zokuhlukunyezwa ezifana ne-carbamazepine ne-phenytoin
- Izidakamizwa ezifana ne-Diflucan (fluconazole) ne-Sporanox (itraconazole)
- Izidakamizwa ezivimbela isisulu ezifana ne-Emend (aprepitant)
- Imithi ye-asthma njenge-Accolate (zafirlukast)
- Aspirin
- Abambalwa begazi abanjengoCoumadin (warfarin)
- I-Diuretics ("amaphilisi amanzi")
- Imithi yenhliziyo efana ne-verapamil, diltiazem, ne-amiodarone
- Imithi yokuphuza inhliziyo njengeTagamet (cimetidine)
- Imithi ye-HIV njengoReyataz (atazanavir), i-Crixivan (indinavir), ne-Kaletra (lopinavir / ritonavir)
- Ukwelashwa kwe-Hormonal
- Izidakamizwa ze-Immunosuppressant
- Amanye ama-corticosteroids
- Wort St. John's Wort
Ukwengeza, isilinganiso esiphezulu noma ukusetshenziswa isikhathi eside kwe-prednisone kunganciphisa impendulo yomzimba emithonjeni ethile futhi ibenze kangcono. Uma uye waphathwa kabi nge-prednisone, kufanele ulinde okungenani izinyanga ezintathu ngemva kokuyeka ngaphambi kokuthola umgomo wokuphila .
Njalo qinisekisa ukuthi unxusa udokotela wakho nganoma yikuphi noma zonke izidakamizwa noma izithako ongase uthathe, kungakhathaliseki ukuthi ziyimithi kadokotela, ongekho odokotela, imithi, ukudla okunomsoco, noma yendabuko.
Okunye okucatshangwayo
Ngesikhathi sokukhulelwa, i-prednisone kufanele isetshenziswe kuphela uma kudingeka. Akubonwanga ukuthi kubangele ubungozi emfundweni yesilwane. Isidakamizwa singadluliselwa kusana olusanda kubisi lwebele kodwa asiyazi ukuthi senza noma yimuphi umonakalo. Nciphisa njalo izinzuzo kanye nobungozi nodokotela wakho ngaphambi kokuqala ukwelashwa.
Yeluleka ukuthi ukwakhiwa kwamanzi kuqukethe kokubili ushukela nophuzo. Kungase kudingeke usebenzise ukubunjwa kwethebhulethi uma enye yalezi zinto ihlasela kabi isimo sezokwelapha ezifana nesifo sikashukela noma isifo sobindi.
Okokugcina, uma ngabe uthatha i-prednisone okwesikhashana, akufanele uyeke ukwelashwa ngokuzumayo. Ukwehlisa kancane kancane izidakamizwa kuzokusiza ukugwema noma ukunciphisa imiphumela emibi eyenziwa ngokuqeda ukwelashwa okungazelelwe.
> Umthombo:
> Firestein, G .; I-Budd, R .; UGabriel, S. et al. (2017) Kelley and Firestein's Textbook of Rheumatology (10th ed .). Philadelphia, Pennsylvania: Elsevier: ISBN: 9780323316965.