Umbuzo othize uvame ukuvela emtholampilo wami wansuku zonke. Iziguli zibuza, "Nginomlando wesifo somdlavuza wesisu kodwa amazinga ami e- testosterone aphansi. Ngingayithola yini i-testosterone? "Impendulo yep pat enikezwa odokotela abaningi" akunjalo neze "-i-testosterone izokwenza njengokushisa emlilweni futhi ijubane nokukhula komdlavuza.
Kodwa ingabe lokhu kuyiqiniso? Impendulo iwukuba "yebo," kodwa kukhona okungenani izimo ezine ezihlukile ezizobhekwa ngezansi.
Kodwa-ke, ngaphambi kokuba sichaze izimo lapho abantu abanomdlavuza we-prostate bangacabanga ukuthatha u-testosterone, kudingeka sixoxe ngokuthi ukuhlolwa kwegazi okulinganisa i-testosterone kuhunyushwa kanjani. Iyini imbangela eqondile echaza ukuthi izinga le-testosterone egazini liphansi kakhulu?
Ukuhlolwa Kwegazi Le-Testosterone
Kunezinkinga eziningi ezihlobene nokuhlolwa kwe-testosterone egazini. Okokuqala, amazinga egazi we-testosterone aphakeme ekuseni futhi aphansi kusihlwa. Isivivinywa esathathwa ngo-4 ntambama ukuthi "siphansi" singase sibe nje ngaphandle kobubanzi obuvamile ngenxa yesikhathi sosuku igazi lithathwe.
Okwesibili, zikhona izinhlobo ezimbili zobuhloli be-testosterone: testosterone esiphelele kanye ne-testosterone yamahhala. Ukuhlolwa okuningi kwesimiso kuphela kulinganisa ubufakazi be-testosterone. Noma kunjalo, i-testosterone yamahhala iyinani elinembile kakhulu lomsebenzi we-physiologic we-testosterone. Lokho kusho ukuthi izazi ziqaphela ngokucacile ukuthi ukuhlobana phakathi kwamazinga alinganiselwe we testosterone mahhala kanye nemizwa yokuziphendulela abantu abalandisa ngayo amandla abo kanye ne-libido ngokuvamile kuvame ukungqubuzana.
Amanye amadoda ane testosterone ephansi kakhulu azivale kahle.
Ukunquma isimo somuntu we-testosterone nokwenza isinqumo mayelana nesidingo se-testosterone therapy akumele sisekelwe kuphela ezingeni le-testosterone egazini. Kubalulekile ukusekela isinqumo sokusebenzisa i-testosterone kumpawu zomuntu.
Iyini iphuzu lokunikeza u-testosterone kumuntu omane ukulungisa imiphumela ephansi ehlonishwayo ekuhlolweni kwegazi uma isiguli sesivele sikhulule?
I-Testosterone Therapy ne-Cancer Prostate
Manje ake sixoxe ngezimo lapho ukunikeza ukwelashwa kwe-testosterone kungase kwamukeleke kumuntu onomdlavuza owaziwayo wesifo sofuba.
Isimo sokuqala sinikeza u-testosterone kumadoda anezinga eliphansi noma izifo ezinzima. Izinhlobo ezithile zomdlavuza wesifo sofuba zingaphansi kwezinga eliphansi kakhulu. Lezi zinhlobo zomdlavuza we-prostate azange zisakazeke futhi kufanele zibizwa ngokuthi izicubu ezinobuthi. Ngeshwa, igama elithi "umdlavuza" linikezwa ngokungafanele kulezi zinhlobo ezibucayi zomdlavuza wesifo sofuba emashumini eminyaka adlule futhi le nqubomgomo yokubiza ngokuthi umdlavuza usinda kuze kube yilolu suku.
Isimo sesibili lapho ukuhlinzeka nge-testosterone kungase kuphephe khona lapho abantu beke behola ukwelashwa noma ukushiswa komzimba futhi babonakala belashwa. Ngemuva kwesikhathi sokulinda esifanele phakathi kweminyaka emibili kuya kwemihlanu, ingozi yokuphindaphinda umdlavuza ngokuvamile iphansi kakhulu. Ukwesaba ukusebenzisa i-testosterone kulesi simo kubonakala kungenasisekelo.
Isimo sesithathu senzeke emadodeni anomdlavuza we-prostate abaye baphinde baphinde bahlinzwa ngemuva kokuhlinzwa noma imisebe. Lesi simo sibonakaliswa ukuthuthukiswa kwezinga elikhulayo le-PSA egazini.
Ngokwesiko, la madoda alawulwa izidakamizwa ezilahlayo ze-testosterone-ehlisa i-Lupron noma i-Firmagon. Ucwaningo lubonisa ukuthi ukulawulwa komdlavuza wesikhathi eside kuyalingana ngokusebenzisa i-Lupron noma i-Lupron eqhubekayo.
Yebo, lokhu kuzwakala kungavamile, kodwa empeleni kuphephile ukuyeka ukwelashwa kwe-anticancer futhi uthathe iholidi. Uma ukwelashwa kumisiwe, ukukhiqizwa kwemvelo ka testosterone kusuka kwamagundane kuvuselela amazinga ajwayelekile e-testosterone egazini. Nokho, ngezinye izikhathi i-testosterone ihlala iphansi, ikakhulukazi kubantu abadala. I-Lupron yangaphambili ibeke izigulane zalawo unomphela.
Uma ukukhiqizwa okuvamile kwe-testosterone kuhluleka ukuqhubeka, kunengqondo ukucabangela ukuphatha i-testosterone. Ngemuva kwalokho, njengoba kuqinisekiswe ukuthi ukuvumela ukubuya okuvela kwamathambo e-testosterone kuphephile, bekungeke kanjani kube nokuphepha ukunikeza ubufakazi obunama-testosterone emazingeni oklanyelwe ukuthola amazinga egazi efana ne-testosterone evame ukutholakala ngamathambo?
Isimo sesine okufanele sicatshangelwe yilapho kunamazinga aphansi e-testosterone kumuntu onomdlavuza owaziwayo wesandulela ngculazi onomzimba obuthakathaka obukhulu noma ukulahleka kwemisipha ephezulu kakhulu ehlobene nokubuthakathaka okuphawulekayo nokuzikhandla. Lesi simo singenzeka emadodeni aneminyaka yobudala obukhulu kakhulu noma ngenxa yesifo esibi kakhulu. Uma abantu bebuthakathaka kakhulu (ngenxa yenqubo ethile ehlobene nomdlavuza ongewona isifo sofuba) kungase kube yingozi kakhulu ukuvimba isifo se-testosterone kunokuba sinikeze, nakuba umdlavuza we-prostate ungacabanga ukuthi ukhula ngokushesha ngenxa yokungena kwe-testosterone. Kubalulekile ukukhumbula ukuthi ngisho "izinhlobo ezimbi" zomdlavuza we-prostate zibonakala zilukhuni ekukhuleni kwabo. Uma kuthathwa isinqumo sokuqala i-testosterone, izinga lokukhula kwesifo lingalandelwa ngokucophelela nge-PSA ukuhlolwa kwegazi nokuhlola komzimba. Uma lezi zivivinyo zibonisa ukuthi umdlavuza uqhubeka ngokungazelelwe ngokushesha, ukwelashwa kwe-testosterone kungamiswa ngokulindela ukuthi umdlavuza uzoyeka ukuqhubekela phambili noma ngisho nokugudluka ngemva kokuba isifo se-testosterone simisiwe.
Kungani Ukudideka?
Ukudideka mayelana nokusebenzisa ukwelashwa kwe-testosterone kumadoda ane-cancer yomzimba wesifo sofuba ivela ngenxa yokuthi umdlavuza wesifo sofuba awuyona isifo esisodwa. Kunamafomu aphansi, aphakathi, futhi aphezulu; izifo zendawo kanye nomdlavuza we-metastatic ; izinhlobo ze-hormonally sensitive kanye nezinhlobo ezingenakuthinta ukwelashwa kwe-hormone. I-protocol eyodwa ayifaneleke yonke indawo kuyo yonke uhlobo lomdlavuza wesicathulo.
Isinqumo sokuqala i-testosterone, ngakho-ke, sibhekene nezinkinga ezimbili. Ngifake kancani ukucatshangelwa kokuqala ngencazelo engenhla yezimo ezine ezikhona ezingamadoda ane-cancer eyaziwayo yesifo sofuba esine-testosterone ephansi futhi angase azuze ngokusebenzisa i-testosterone eyengeziwe. Inkinga yesibili ihlobene nezingozi zokusebenzisa i-testosterone ngendoda engavamile enempilo engenawo umdlavuza wesicathulo. Ucwaningo luye lwabonisa ukuthi ukunikeza testosterone akuphephile ngokuphelele-ngisho nasemadodeni angenayo umdlavuza wesicathulo noma yini.
Amazinga e-Testosterone egazini athambekele ekuncipheni ngeminyaka. Amadoda amaningi afana nalokhu kunciphisa okuthobekile ku-testosterone ngaphandle kokubhekana nobunzima obungadingekile. Kodwa-ke, kunezimpendulo ezithile, okungenzeka kube nomphumela wokuba nomthelela ophansi we-testosterone, ikakhulukazi uma isifo se-testosterone sicacisiwe. Le miphumela ye-testosterone ephansi ihlanganisa amazinga aphansi aphansi, i-sex low drive, ukukhathazeka, izinkumbulo zememori, inzuzo yesisindo, ukukhuliswa kwesifuba, futhi ngezinye izikhathi, ukusheshiswa kwe-calcium ukulahlekelwa emathanjeni-okusho ukuthi i-osteoporosis. Yonke le mibi emibi ye-testosterone ephansi ingalinganiswa ngokubuyisela izinga elijwayelekile le-testosterone egazini.
I-Testosterone Therapy Administration and Risks?
Ukunikeza ukwelashwa kwe-testosterone kungahle kutholakale emafomethi ahlukene ahlukahlukene, kuhlanganise nokusetshenziswa kwezigxobo ezincane noma ezinde, ama-creams, ama-gel, nama-patchermal patches. Ukusetshenziswa kokwelashwa kulula. Nokho, njengoba kuphawuliwe ngenhla, ukwelashwa kwe-testosterone akuyona ingozi (ngaphandle kwezingozi zokuyisebenzisa emadodeni anomdlavuza wesifo sofuba). Ukukhathazeka okukhulu kwe-testosterone ukuguqula ukwelashwa okuwukuthi ukuthuthukiswa kwezibalo ezibomvu zamangqamuzana egazi eziphakeme kunezinye ezijwayelekile-igama lobuchwepheshe liyi-hematocrit ephezulu. I-hematocrit, evame ukufinyezwa njenge-Hct, iyingxenye yephaneli legazi, i-CBC noma inani eliphelele legazi. Elinye igama lobuchwepheshe ongase lihlangabezane nalo elidlulisela incazelo efanayo ne-hematocrit ephezulu "i- polycythemia ."
Ukubala okubomvu okuphezulu kusho ukuthi igazi liba yi-viscous more (ukuqina kwegazi), okungahle kwenzeke ezinkingeni ezinzulu ezifana nokuhlaselwa yinhliziyo nokushaya. Ukuqapha ngokucophelela kwe-hematocrit kuyadingeka, ngakho-ke, kuwo wonke umuntu ohlela ukufaka esikhundleni se-testosterone. Kufanele i-hematocrit ephakeme ithuthuke ngenkathi i-testosterone therapy, okungukuthi, uma i-hematocrit iphakama ngaphezu kwamaphesenti angu-50, kufanele kusetshenziswe uhlobo oluthile lokuqapha. Izindlela ezinjalo zingase zihlanganise nokususwa ngezikhathi ezithile kweyunithi yegazi kumkhuba we-hematologist noma mhlawumbe ukunciphisa umthamo we-testosterone.
Ukuphathwa kwe-testosterone yokwelashwa esikhundleni sekuye kwaba ngendlela efanele, futhi emadodeni ngaphandle komdlavuza we-prostate, ukusetshenziswa kwayo sekuthandwa kakhulu. Njengoba kuphawuliwe ngenhla, akuwona wonke umuntu owelashwa nge-testosterone othola uhlobo lwezinzuzo ezingalindelwa-izinzuzo ezifana nokwanda kwe- libido noma amazinga wezamandla akhulayo.
Emva kweminyaka eminingi yokuhlangenwe nakho enikeza ukwelapha kwe-testosterone kumadoda amaningi, ngiye ngafunda ukuthi kukhona ukuhluka okukhulu ngendlela abantu abazoyiphendula ngayo. Ngezinye izikhathi umthelela we-testosterone uyashesha futhi uyamangalisa. Kwamanye amadoda, ngisho nangemva kokulinda okwanele kwezinyanga eziyisithupha, inzuzo ebonakalayo ingase ilahleke.
Indlela kuphela yokuthola ukuthi umuntu othize uzozuza yini ku-testosterone ukuqala uvivinyo futhi aqaphele lokho okuphelelwa yisikhathi ezinyangeni eziyisithupha noma ngaphezulu. Kunesidingo esanele sokweluleka ukuze kutholakale ukuthi umphumela ozuzayo uzokwenzeka. I-testosterone ayibangeli imiphumela yesikhashana njengamanye ama-hormone, njenge-adrenaline, isibonelo.
Thola i-Cancer yakho yomdlavuza
Kuze kube yilapho okuningi okukhulunywe ngakho sekuyizinga elijwayelekile futhi abaningi be-endocrinologists kanye nodokotela jikelele bayazazi ukulethwa kwe-testosterone ukwelashwa kwamadoda ngaphandle komdlavuza we-prostate. Isimo esicindezelayo, njengoba kuboniswe ngenhla, singamadoda asebenza kaningi noma aphethwe isifo somdlavuza we-prostate ngaphambili. Phela, ukwelashwa kwe-testosterone ukunciphisa enye yezindlela ezithandwa kakhulu ukulwa nomdlavuza wesifo sofuba. Ngakho-ke, ukuphathwa kwe-testosterone eyengeziwe emadodeni anomdlavuza wesibeletho kungabi yingozi kanjani? Impendulo yukuthi uhlobo lomdlavuza wesifo sofuba kufanele luchazwe ngokucacile.
Umdlavuza we-prostate osebenzayo ungahlukaniswa ngezigaba ezimbili ezibanzi-izinhlobo ezingenabungozi (ikakhulukazi, lezo ezizimisele ukuba zebanga lesithupha noma ngaphansi njengoba kunqunywe nge-biopsy yenaliti noma ngokuhlinzwa), kanye nezinhlobo eziningi ezilandelanayo, zihlanganiswa kusukela eziyisikhombisa kuya kweziyishumi. Izici ezengeziwe ezifana ne- PSA nemiphumela yezingcingo ezihlukahlukene zingathinta nokuthatha izinqumo. Ezimweni eziningi, ukuhlolwa komculi wesifo somdlavuza we-prostate kuyodingeka ukuthi wenze isinqumo sokugcina mayelana nokuphepha kokunikeza ukwelashwa kwe-testosterone kumuntu onomlando womdlavuza wesifo sofuba.
> Imithombo:
> AVEED ® (Ukubhala Ulwazi). Malvern, PA: Endo Pharmaceuticals Inc.
> U-Edelstein D, no-Basaria S. "I-testosterone engadingeki ekwelapheni kwe-hypogonadism yamadoda." Umbono wophiko lwe-pharmacotherapy 11.12 (2010): 2095-2106.
> Eisenberg, ML. "I-Testosterone Alternative Therapy futhi Incidence Cancer Incidence." I-World Journal of Men's Health 33.3 (2015): 125-129. PMC . Iwebhu. 28 Mashi 2017.
> Pickles, T, et al. "Ukuphulukiswa kwe-testosterone kulandela i-adjuvant androgen ablation ye-prostate carcinoma." I-Cancer 94.2 (2002): 362-367.
> Izinga le-testosterone ziyizinto ezibalulekile. Ingxoxo noDkt Laurence Klotz ngeProstatepedia. http://pcri.org/insights-blog/2016/4/6/testosterone-levels-are-yingqayizivele-.