Ngasekupheleni kweminyaka yama-1990, isidakamizwa sokuqala se-biologic sahamba emakethe ukuze siphathe isifo samathambo esifubeni . I-Enbrel (etanercept) yayiqala, kodwa akuzange kuthathe isikhathi eside ukuthi ezinye izidakamizwa ze-biologic zithuthukiswe futhi zithengiswe.
Ngokusho kwe- UpToDate ( irekhodi elithembekile le-elektroniki elisetshenziswe odokotela abaningi neziguli abafuna imininingwane ejulile yezokwelapha echazwe kahle):
"I-Biologic response modifiers, eyaziwa nangokuthi yi-biologics, imithi eyenzelwe ukuvimbela noma ukunciphisa ukuvuvukala okulimaza amalunga. I-Biologics ihlose ama-molecule emangqamuzaneni omzimba, okuhlangene, nemikhiqizo efihliwe ngokuhlanganyela, konke okuyiyo kungabangela ukuvuvukala kanye nokubhujiswa okuhlangene. Kunezinhlobo eziningana zezinto eziphilayo, okuyilowo nalowo ohlose uhlobo oluthile lwe-molecule ehilelekile kule nqubo (i-tumor necrosis factor, interleukin-1, nama-cell molecules on the T and B-lymphocyte). "
Izidakamizwa ze-biologic kanye nezinjongo zazo
- Enbrel (etanercept), Remicade (infliximab), i- Humira (adalimumab), i- Simponi (golimumab) ne- Cimzia (i-certolizumab pegol) yizidakamizwa ze-biologic ezikhomba i-necrosis factor factor (TNF). Zivame ukubizwa ngokuthi yi- TNF blockers futhi, ngokuvamile, esinye sezivimbela ze-TNF yisilingo sokuqala se-biologic esalinga.
- I-Kineret (anakinra) inhibits i-interleukin-1. Ngokuvamile kubhekwa njenge-biologic engasebenzi kangcono kunama-blockers we-TNF futhi ngokuvamile ayinqunyelwe.
- I-Orencia (abatacept) iphazamisa ukusebenza kwamaseli T. Ngokuvamile, i-Orencia igcinwe iziguli ezinomqondo ohambelana nesifo samathambo esibi kakhulu esingakwazi ukuphatha isifo sabo nge-methotrexate ne-blocker ye-TNF.
- I-Rituxan (rituximab) idonsa amaseli B. Futhi, lesi sidakamizwa ngokuvamile sigcinelwe iziguli ezinomphumela ongathandeki nge-methotrexate ne-blocker ye-TNF.
- I-Actemra (tocilizumab) isebenza ngokuvimbela i-interleukin-6 receptor, ngaleyo ndlela ivimbele i-interleukin-6.
Ubani Okufanele Aphathwe Ngeziphilayo?
Iziguli eziye zathola impendulo enganelisekile kuma- DMARD (izifo eziguqula izifo ezibulala i-antirheumatic), noma zodwa noma ezihlangene nezinye izidakamizwa zamathambo, zivame ukhetho oluhle lwezinto eziphilayo. Uma kuqhathaniswa ne-DMARD, i-biologics isebenza ngokushesha. Kufanele wazi ukuthi uyaphendula yini phakathi kwamasonto ukuqala isidakamizwa se-biologic.
Ubani Okungafanele Asetshenziswe Ngama-Biologics?
Ngeshwa, zikhona iziguli ezingekho ukhetho olufanele ukwelashwa ngezidakamizwa ze-biologic. Kunezimo ezithile lapho izingozi zingase zibe khona kakhulu izinzuzo zokwelashwa nezidakamizwa ze-biologic.
Isibonelo, iziguli ezinomlando wangaphambili we- multiple sclerosis noma i-lymphoma angeke zibe yizikhethelo ezinhle. Iziguli ezinezinkinga ze-heart congestive heart failure nazo azizona ezikhethiwe. Kubuye kube yingozi kakhulu ukusebenzisa izidakamizwa ze-biologic lapho isiguli sinomlando wezifo ezinzima noma eziphindaphindiwe.
Yiziphi zezinto eziphilayo okufanele uzisebenzise?
Udokotela wakho uzokusiza ukhethe i-biologic engcono kakhulu kuwe. Izindleko ngokuqinisekile zicatshangelwa. Wena nodokotela wakho kufanele nithole ukuthi umshuwalense wakho wezempilo uzothola yini izidakamizwa ozikhethayo-noma ukuthi yiziphi izindleko zakho ezingaphandle kwe-pocket.
Qinisekisa ukuthi kungabizi kakhulu kuwe.
Okunye okucatshangelwayo kulula. Isidakamizwa senziwa kanjani? Ingabe kufanele uhambe ehhovisi likadokotela ukwelashwa noma ngabe kungcono kuwe ukuthi ukhethe omunye wezidakamizwa ze-biologic ezenziwa njenge-self-injection? Isikhathi esingakanani umuthi olawulwayo-kanye ngesonto, kabili ngesonto, njalo amasonto amabili, noma ngenyanga? Yini oyithandayo?
Futhi, kubalulekile ukuthi ukhethe umuthi onomlando omuhle wethrekhi, ngamanye amazwi, omunye wabantu abadala, kunokuba omusha, biologics? Lezi zonke izinto okufanele uzicabangele ngoba uma ukhetha ukuthi yini okufanelana nayo, cishe uzohlala uvumelana nemithi yakho.
Umthombo:
I-Maini RN ne-Venables PJW. Ukwaziswa kwesineke: Ukwelashwa kwamathambo e-Rheumatoid "UpToDate.