Umbuzo: Ingabe Kufanele Uthathe CoQ10 ngeSitatimende?
Udokotela wami ungifake nge-simvastatin generic ukuze nginciphise i-cholesterol yami. Ngibonakala ngibekezelela kahle, kodwa ngizwile ukuthi uma uthatha isidakamizwa se-statin, kufanele uthathe i-CoQ10 ukuvimbela izinkinga zomzimba. Ingabe lokho kuyiqiniso? Ingabe kufanele ngithathe i-CoQ10?
Impendulo: Ngeshwa, ayikho impendulo ecacile yalo mbuzo.
Kodwa-ke, ubufakazi obumtholampilo okufanele sibhekane nabo buveza ukuthi i-CoQ10 ayinakusiza kakhulu, uma kunjalo, ukuvimbela noma ukuphatha izinkinga zemisipha eneziqu.
Kuyini i-CoQ10?
I-CoQ10 - eyaziwa ngokuthi ubiquinone - i-coenzyme esiza imisipha ukukhiqiza amandla abayidingayo ukwenza umsebenzi wabo. Ngenkathi ezinye izifundo ziphakamisa ukuthi izitembu zinganciphisa inani le-CoQ10 kumzimba wesisu, ezinye izifundo azitholanga ukwehla kwamazinga we-CoQ10 nama-statins. Ngakho ngisho nombuzo wokuthi ama-statins angathinta amazinga we-CoQ10 nhlobo akucaci ngokuphelele. Kunoma yikuphi, abaningi baye bacabanga ukuthi amazinga aphansi weCoQ10 angase abe nomthelela ekwenzeni i- myopathy (ukulimala kwemisipha) okungenzeka ngezimo zesimiso . Ngakho-ke, abanye odokotela batusa ukwesekwa kwe-CoQ10 ne-statin therapy.
Uyini Ubufakazi On CoQ10 kanye Statins?
Izincwadi zezokwelapha zixubene nombuzo weCoQ10, futhi ngezizathu ezimbili.
Okokuqala, njengoba kukhonjisiwe, akuzona zonke izifundo ezibonisa ukuthi izitembu zithinta amazinga we-CoQ10 kumzimba wesisindo ngokwawo.
Futhi okwesibili, izifundo noCoQ10 kubantu abathatha izitembu ziye zincane kakhulu. Izifundo ezimbalwa, ezincane, ezincane zesikhathi esifushane seziphelile, futhi imiphumela yalezi zifundo ezimbalwa ziye zadumaza.
Ucwaningo lwezokwelapha oluye lwaqhutshwa kuze kube manje luye lwahlola ikhono le-CoQ10 ukuphatha ubuhlungu besisu obubangelwa yi-statin.
Inhloso yalezi zifundo kwakuwukucacisa ukuthi ukuthatha i-CoQ10 kungavumela iziguli ezinezinhlungu zomzimba ezenziwe ngomzimba ukuthi ziqhubeke nokuthatha izitembu. Lokhu kuyindaba ebalulekile, ngoba uma kuziwa ekunciphiseni ubungozi benhliziyo ngenxa yamazinga e-cholesterol, akusekho okwakumele kufakwe esikhundleni sesimiso .
Lezi zifundo zenze imiphumela ephikisanayo. Ukuhlolwa kwesilingo esingahleliwe ngeziguli ezingu-32 ezinezinhlungu zomzimba ezinama-statically showed that, emva kwezinsuku ezingu-30, labo abathola i-CoQ10 banciphise kakhulu ubuhlungu besisindo uma kuqhathaniswa nalabo abangenayo i-vitamin E. engaphenduki. inkinga, noma kunjalo, ngoba kuthatha izinsuku ezingaphezu kwezingu-30 ze-CoQ10 ukwengezwa ukuthi kuthinte inani le-CoQ10 emisipha ngokwabo. Ngaphezu kwalokho, izinyathelo eziningana ezifanayo, ezinde isikhathi eside ne-CoQ10 azibonanga ukuthuthukiswa kobuhlungu besisu kuma-statins.
Ukuze uzame ukuxazulula le nkinga, ukuhlaziywa kwe-meta kwenziwa ngo-2015, ukuhlaziya ukuhlolwa okukhona okungahleliwe. Lokhu kuhlaziywa akutholakalanga inzuzo ephawulekayo uma i-CoQ10 isetshenziselwa ukuphatha ukuphika komuntu okwenziwa yi-statin. Noma kunjalo, ikhwalithi yezifundo ezitholakalayo isalokhu inkinga, ngakho imiphumela yalokhu kuhlaziywa kwemeta ayikwazi ukubhekwa njengokucacile.
Izivivinyo ezinkulu, ezinde isikhathi eside kungadingeka ukuthola isibambiso kulo mbuzo.
Akekho kulokhu, kodwa, uthola ngempela embuzweni wakho, okungukuthi, uma umuntu ethatha izitegimenti futhi ethatha i-CoQ10 ukuvimbela i- statin myopathy? Isizathu engikhulume ngaso kuphela ngokusebenzisa i-CoQ10 ukuphatha ubuhlungu besisu esisemthethweni ukuthi kukhona okungenani idatha etholakalayo eyakhela lo mbuzo (njengokungathi kube sengathi leyo datha ingaba).
Kodwa uma kuziwa ekusebenziseni i-CoQ10 njengesilinganiso sokuvimbela, ubufakazi obukhona kuphela bukhona ngokuphelele. Azikho izilingo ezilawulwa ngokungahleliwe ezilawulwe ngokungaphenduliyo ezibhekana nale mbuzo.
I-CoQ10 ne-Statins - I-Bottom
Okubalulekile ukuthi akukho bufakazi obuhle, obunomgomo obuvela ezivivinyweni zomtholampilo bukhona ukuze kuboniswe ukuthi i-CoQ10 ivimbela noma isebenzise ngokuphumelelayo ubuhlungu besisu obubangelwa yisimiso. Ngesikhathi esifanayo, inkolelo yokuthi CoQ10 ingase isize ihlale ihlaba umxhwele, futhi izifundo ezenziwe zincane kakhulu emkhakheni wabo kanye nobude bawo. Ngaphezu kwalokho, ukuthatha izithako ze-CoQ10 (njengokuthi ubani owaziyo) akulimazi.
Ngakho uma unesithakazelo ekuzameni, futhi ungakwazi ukuyikhokhela, odokotela abaningi abazwakalise ukuphikiswa okunamandla kulo mbono.
Uma unesifo sensizwa ngenkathi usesimweni esifanele, kufanele ukhulume nodokotela wakho mayelana nokuzama esinye sezidakamizwa ze-statin esaziwa ukuthi akunakwenzeka ukukhiqiza izinkinga zomzimba, okungukuthi, i-Lescol (fluvastatin) noma iPravachol (pravastatin). Futhi, qiniseka ukuthi udokotela wakho uhlola umsebenzi wakho we-thyroid kanye namazinga akho e-vitamin D, ngoba i- hypothyroidism noma i-vitamin D ephansi izokwenza isimo se-statin myopathy.
> Imithombo:
> Banach M, uSerban C, uSahebkar A, et al. Imiphumela ye-Coenzyme Q10 kwi-Myopathy eyenziwe yi-Statin: ukuhlaziywa kwe-Meta yemizamo elawulwa ngokungahleliwe. I-Mayo Clin Proc 2015; 90:24.
> Bookstaver DA, Burkhalter NA, Hatzigeorgiou C. Umphumela weCoenzyme Q10 Ukwengezwa kwi-Myalgias eyangenelwa yi-Statin. Am J Cardiol 2012; 110: 526.
> Caso G, Kelly P, McNurlan MA, Lawson WE. Umphumela weCoenzyme q10 kwizimpawu zeMyopathic eziguli eziphathwe ngeSitatimende. Am J Cardiol 2007; 99: 1409.
> Taylor BA, Lorson L, White CM, Thompson PD. Isivivinyo Esingahleliwe seCoenzyme Q10 ezigulini ezineStatin Myopathy eqinisekisiwe. I-antherosclerosis 2015; 238: 329.