I-Juxtapid (i-lomitapide) imithi esetshenziselwa amazinga amaningi e-cholesterol, ama-LDL, nama- apolipoprothein B amazinga-kanye nokudla nezinye izifo - kubantu abane- hypercholesterolemia yomndeni ongavamile , okuyizinto ezingavamile, ezithatha njengefa ezibangelwa kakhulu amazinga e-LDL ama-cholesterol nesifo senhliziyo isifo ekuqaleni kokuphila. I-Juxtapid yavunyelwa ukusetshenziswa e-United States yi-Food and Drug Administration ngoDisemba 2012.
I-Juxtapid isifunde ngokucophelela kubantu abaxilongwa nge-homopergous family hypercholesterolemia - hhayi kubantu abanezinye izimo ezibangele amazinga aphezulu e-cholesterol. Kwesinye isifundo, uJuxtapid 5 kuya ku-60 mg nsuku zonke wanikezwa abantu abavele bathatha ezinye izindlela zokwelapha ze-cholesterol ezingeni eliphezulu kakhulu ze-LDL cholesterol. Lolu cwaningo luveze ukuthi ukungeza ama-Juxtapid kwezinye izindlela zokwelapha kwehlisa amazinga e-LDL ngo-50%. Amazinga e-Triglyceride, ama-apolipoprotein B, ama-VLDL namazinga e-cholesterol aphelele nawo anciphisa kakhulu.
Olunye ucwaningo luhlolisise ukuphumelela nokuphepha kubantu abanesimo esifanayo sezokwelapha esithatha uJuxtapid yedwa ekunciphiseni amazinga e-cholesterol. Ekuphetheni kwalolu cwaningo, ngomthamo we-1 mg / kg / usuku, amazinga e-LDL nama-apolipoprothein B aphinde ancishiswe ngama-50%.
Nakuba lezi zithole zasiza kakhulu i-cholesterol kule ndawo yesiguli, ziye zaveza ukuthi i-Juxtapid ingabangela imiphumela emibi kakhulu - kuhlanganise nemiphumela emibi yesisu kanye nesifo sebindi.
Ukwengeza, njengoba lezi zifundo zithatha amasonto angu-78 kuphela, ezinye izifundo ziqhutshwa okwamanje ukuze zithole ukuphepha nokusebenza kwesikhathi eside kweJuxtapid.
Isebenza kanjani?
I-Juxtapid inciphisa i-cholesterol ye-LDL ngokuvimbela amaprotheni wokudlulisa i-microsomal triglyceride (MTTP), i-molecule emzimbeni ovimbela i-VLDL namakhelomu- chyloni ukuba zenziwe esibindi.
Ngenxa yokuthi i-VLDL iguqulwa ibe yi-LDL, lokhu kuzokwehlisa izinga lamaLDL egazini.
Kufanele Ngithathe Kanjani Le Mithi?
I-Juxtapid kufanele ithathwe ngomlomo, ngilazi yamanzi, esiswini esingenalutho. Kunconywa ukuthi imithi ithathwe okungenani amahora amabili emva kokudla. Umhlinzeki wakho wezempilo uzothatha ukuhlolwa kwegazi - kuhlanganise nokuhlola ama-enzyme yesibindi namazinga we-cholesterol - ngaphambi kokubeka i-Juxtapid kuwe.
Imiphumela Ezingenakwenzeka
Ama-enzyme ephakeme wesibindi nokuqoqwa kwamafutha esibindi kuye kwahlotshaniswa kakhulu ngokuthatha i-Juxtapid. Ngakho-ke, udokotela wakho kuzodingeka athathe ukuhlola kwegazi njalo ukuze anqume amazinga e-enzyme yesibindi, afaka ama-alanine aminotransferases, ama-aspinate aminotransferases, ne-alkaline phosphatase, ngaphezu kokuqapha amazinga akho e-cholesterol. Ngenxa yale miphumela emibi, i-Juxtapid ithatha "isixwayiso sebhokisi elimnyama" socwaningo lwe-hepatotoxicity, esiyisixwayiso esinamandla esikhishwe yi-Food and Drug Administration ngenxa yokuthi le mpumelelo yecala ibonwe ekuhloleni kokuhlola ukuphepha kwezidakamizwa. Ngenxa yomphumela onobungozi u-Juxtapid unesibindi, udokotela wakho uzokubhalisa ohlelweni oluvinjiwe, olubizwa ngokuthi uhlelo lwe-Juxtapid REMS.
Ngaphansi kwalolu hlelo, odokotela kanye nama-pharmacy kuphela abaqinisekisiwe ekuqondeni imithi kanye nezingozi zayo bangabhala futhi basakaze uJuxtapid.
Imiphumela emibi yemithanjeni, njenge-nausea, ukuhlanza, ukushaya inhliziyo, isifo sohudo, ukuqothulwa nobuhlungu besisu, kube yimiphumela emibi kakhulu ebikiwe kubantu abathatha i-Juxtapid. Abanye abantu baye babika nokubhekana nokulahlekelwa isisindo, ubuhlungu besifuba nokukhathala ngenkathi bethatha imithi.
Ngubani Okungafanele Awuthathe?
Njengamanje, i-Juxtapid iye yafundwa kuphela kubantu ababhekene ne-homopergous family hypercholesterolemia ngenxa yobungozi babo obukhulu besifo senhliziyo.
Ngakho-ke, aziwa ukuthi i-Juxtapid iyasebenza yini kubantu abanezinye izimo zezokwelapha ezibangelwa amazinga aphezulu e-cholesterol. Abanye abantu okufanele baxoxe nodokotela wabo ngaphambi kokuthatha i-Juxtapid kufaka phakathi:
- Abantu abanezifo zesibindi - i-Juxtapid ingaqhubeka nokwandisa ama-enzyme ebindi njengama-transaminases nokwandisa amafutha esibindi.
- Abantu abanesifo sezinso - amazinga kaJuxtapid angakhuphuka egazini.
- Abesifazane abakhulelwe - I-Juxtapid iboniswe ukuthi iyingozi kumntwana ekufundeni kwesilwane. Abesifazane abakwazi ukukhiqiza bazodinga ukuhlolwa kokukhulelwa okungakahlekile ngaphambi kokuqala iJuxtapid futhi kuzodingeka basebenzise uhlobo oluthile lokulawulwa kokuzalwa okuphumelelayo ngenkathi bethatha imithi.
- Abesifazane abahlengikazi - uJuxtapid akafundile kakhulu. Ngenxa yokuthi kungenzeka ukuthuthukiswa kwe-tumor kumagundane, kunconywa ukuthi uhlengikazi - noma umuthi - kufanele ususwe.
Ukusebenzisana kwezidakamizwa
Kukhona imithi ethile engase ixoxisane noJuxtapid, okungabangela ukuthi kuthinte ukuhlushwa kweJuxtapid noma iminye imithi emzimbeni. Okulandelayo luhlu oluncane lwemithi engaxhumana noJuxtapid ngakho uma uthatha eyodwa noma ngaphezulu yale mithi, kufanele uxhumane nodokotela wakho.
- Amavithamini ayenamafutha anamanzi nezakhi, njengevithamini A, D, E, ne-K, nama -fatty acids ama-omega-3 , angeke atholakale ngenkathi ethatha i-Juxtapid.
- I-Juxtapid ingakwandisa amazinga egazini egazini elithile elincane , njenge-warfarin, egazini. Lokhu kungabangela ukuthi uphephe noma ukhululeke kalula.
- Uma uthatha i-atorvastatin noma i-simvastatin, i-Juxtapid ingakhuphula amazinga wegazi lala mithi. Udokotela wakho angashintsha umthamo wakho wale mithi ngenkathi ethatha i-Juxtapid.
Ngenxa yokuthi i-Juxtapid isetshenzisiwe emzimbeni, ingakhuphula amazinga wegazi eminye imithi oyithathayo-ngakho-ke ukwenza imithi ibe yingozi kakhulu. Lezi zihlanganisa izidakamizwa ezithile eziphikisayo, ama-antibiotics, izidakamizwa ze-antiviral, imithi yomshoshaphansi wegazi, izidakamizwa ezisetshenziselwa ukwelashwa kwenhliziyo, nemikhiqizo yemvelo (njengegolide, i-grapefruit). Ngakho-ke, kufanele ugcine bonke abahlinzeki bakho bezempilo bekwaziswa nganoma yikuphi imithi oyithathayo ukuze bakwazi ukuhlola ngokwanele ukuxhumana okungenzeka noJuxtapid. Udokotela wakho anganquma ukushintsha umthamo wakho weJuxtapid noma iminye imithi uma kutholakala ukuxhumana.
Ngaphansi
I-Juxtapid yilapho i-cholesterol yokuqala-imithi ephansi evunyelwe ukuthi ivimbele i-MTTP. Nakuba ucwaningo luye lwabonisa ukuthi uJuxtapid unezela ikhono lokunciphisa i-LDL ekwenzeni abantu abanomdlavuza we-homozygous hypercholesterolemia, kunezinkinga eziningi zokuphepha ezihlobene neJuxtapid futhi ukusetshenziswa kwayo kuye kwaba kuphela kule ndawo yesifo ngenxa yalezi zingozi. Udokotela wakho uzohlola izinzuzo zokuthatha uJuxtapid, kanye nezingozi zokubhekana nemiphumela emibi nomuthi. Ngenxa yokuthi imiphumela yesikhathi eside yokuthatha i-Juxtapid ayiziwa - kubandakanya ikhono layo lokuvimbela isifo senhliziyo - kukhona izifundo okwamanje eziqhubekayo zokuhlola lokhu.
Imithombo:
I-Cuchel M, Meagher EA, i-HD HD, et al. Ukusebenza nokuphepha kwe-prophytical inhibitor yokudlulisa i-microsomal triglyceride ezigulini ezine-homopergous family hypercholesterolemia: ingalo eyodwa, i-label evulekile, isifundo sesi-3. Lancet 2013; 381 (9860): 40-6.
I-Cuchel M, i-Bloedon LT, i-Szapary PO, et al. Ukuvimbela amaprotheni wokudlulisa i-microsomal triglyceride e-hypercholesterolemia yomndeni. N Eng J Med 2007; 356: 148-156.
I-Juxtapid ® (i-lomitapide) Iphakheji Faka. Aegerion Pharmaceuticals. NgoMashi 2016.