Izidakamizwa ze-statin zingase zisebenze i-Gene Yokudambisa Ubuhlungu Bamasipha
Izitatimende zingamaqembu e-cholesterol-ukwehlisa imithi esebenza ngokuvimbela amaprotheni ayisihluthulelo, i-HMG-CoA reductase, okuyinto enesibopho sokwenza i-cholesterol esibindi. Lezi zidakamizwa ziyasebenza ekunciphiseni imivimbo kanye nokuhlasela kwenhliziyo.
Izigidi zaseMelika zithatha iziqu ngoba ziqondisa kahle zonke izici zephrofayili yakho ye- lipid ngokunciphisa i- LDL cholesterol kanye ne- triglycerides ngenkathi iphakamisa i- HDL cholesterol.
Nokho, njengemithi eminingi, kunezimo ezimbi ezingase zibe khona.
Imiphumela emibi yesimiso ihlanganisa:
- ubuhlungu besisu njengethonya elivame kakhulu
- ukwandisa ekukhiqizeni ama-enzyme esibindi njengempembelelo yangezinye izikhathi
- ukulimala kwemisipha nesibindi njengomphumela ongavamile wecala
- izinkinga zokugaya ukudla, kuhlanganise negesi, isifo sohudo noma isicanucanu, njengomphumela ongavamile
- ukwanda kwe-ushukela wegazi, okungaholela ekuthuthukiseni isifo sikashukela sohlobo lwesibili, kuyingozi encane, kodwa kungenzeka
- imiphumela eguquguqukayo ye-neurological effects, kuhlanganise nokulahleka kwenkumbulo nokudideka, yisixwayiso esivela e-US Ukudla Nezidakamizwa Zokuphatha ezivela emalebula esitetimenti
Umphumela Ohlangothini Wezitatimende I-Muscle Pain
Amaphesenti angaba ngu-5 kuya kwezingu-10 eziguli ezithatha izitho zomzimba zithola imiphumela emibi emibi emitholampilo, ephakeme kunemibiko yasekuqaleni. Izimpawu zingase zivele ezinyangeni eziyisithupha zokuqala zokwelashwa noma zivele emva kweminyaka eminingana.
Uma kuziwa ebuhlungu besisindo, imiphumela emibi ingase ibangele ubuthakathaka obuthakathaka obuthakathaka kuze kube yi- rhabdomyolysis esongela ukuphila, engavamile.
Ingozi yakho yokulimala kwemisipha ngenkathi uthatha iziqu zixhomeke ezinhlobonhlobo zezici, kubandakanya:
- ube ngaphezu kuka-80, owesifazane, noma omncane
- ukuphuza ijusi lamagilebhisi
- ukuphuza amanzi noma ukuphuza utshwala ngokweqile
Ucwaningo olushicilelwe enkampanini ka-2016 yeNew England Medical Journal lubonisa ukuthi ama-myopathies ahlobene nesimo se-statin nawo anemiphumela emibi yesimiso.
Lesi sici esibi kakhulu sokuchitha isimo asivamile futhi sibonakala ngengxenyana yeziguli.
Isizathu Sokuthi Kungani Izitatimende Zomsundu Wezinhlungu Zezinhlungu
Ucwaningo lwangaphambili lubonisa ukuthi i-gene atrogin-1 ivuleka ezinyathelweni zokuqala zokuphazamiseka kwemisipha (ukuchitheka kwemisipha), ehlobene nezifo ezifana nomdlavuza , isifo se-sepsis , ne- AIDS . Uma isakhi se-atrogin-1 singasebenzi, ukushaywa kwemisipha akukwenzeka.
Ososayensi e-Beth Israel Deaconess Medical Centre eBoston, eMassachusetts babecabanga ukuthi i-atrogin-1 ingase ibe neqhaza ekuthuthukiseni ama- myopathies kulabo abathatha izitembu. Ukuhlola lokhu, abaphenyi banikeza isimo se-statin, iMevacor (lovastatin) , emaseleni omzimba akhulayo, inhlanzi ye-zebra nabantu.
Abacwaningi bathola ukuthi abantu abasebenzisa i-lovastin babe namazinga aphezulu e-atrogin-1 kunalabo abangathathi izidakamizwa. Uma i-Mevacor eyengeziwe inikezwa ngamaseli kanye nenhlanzi ye-zebra, cishe kungenzeka ukuthi ukulimala kwemisipha kuzokwenzeka. Lapho i-atrogin-1 isusiwe kumaseli, isidakamizwa asizange sibangele ukulimala kwemisipha.
Lolu lwazi luyisandulela, kodwa lusinikeza ukuqonda ukuthi yini engabangela ubuhlungu be-muscle kubasebenzisi be-statin, nokuthi kungani abanye abantu bethatha izitho zomzimba bangase babe nengozi kulokhu kunabanye.
Esikhathini esizayo, lokhu kungavumela umhlinzeki wakho wokunakekelwa kwezempilo ukuthi abone ukuthi usesengozini ye- myopathies ehambisana nesimo se-statin, kusukela ebuhlungu obukhulu bomzimba obuyisifo somzimba kuya ku- rhabdomyolysis esongela ukuphila.
Ukwengeza, ososayensi bangakwazi ukusebenzisa lolu gesi, noma abanye ababandakanyekile, ukuvimbela ukulimala kwemisipha okubangelwa iziqu.
Imithombo:
I-Hanai JI, i-Cao P, i-Tanksale P, et al. I-ubiquitin ethize ye-muscle igxile i-atrogin-1 / MAFbx isebenzelana nobuthi obubangelwa yisimiso esenziwe ngumzimba. J Clin Invest. 117 (12): 3940-3951.
Amammen, Andrew. I-New England Medical Journal of Medicine: I-Statin-Associated Autoimmune Myopathies (2016)
I-Mayo Clinic: Imiphumela ye-Statin Side Effects - Weight Benefits and Risks (2013)