Akukhona nje Ukucindezeleka
Kuzo zonke izifo zokwelapha i- fibromyalgia (i-FMS) nesifo esingapheliyo sokukhathala ( ME / CFS ), izidakamizwa zokucindezeleka zingase zibe nzima kakhulu kubantu ukuyiqonda. Kuvame ukuba abantu badideke ngokuthi kungani le mithi ihlelwe ngezimo ngaphandle kokucindezeleka.
Kodwa-ke, ubufakazi obusayo obukhombisa ukuthi izidakamizwa zokulwa nokucindezeleka ziyindlela yokwelapha ephumelelayo ye-FMS, futhi ngezinga eliphansi, ME / CFS.
Ama-anti-depressants ashintsha indlela ezinye ze-neurotransmitters ezisebenza ngayo ebuchosheni bakho, futhi ama-neurotransmitter afanayo abandakanyeka ku-FMS, ME / CFS, nokucindezeleka okukhulu okucindezelekayo.
Izinhlobo ezimbili ze-antidepressants eziboniswa ukuthi ziphumelela ngokumelene nezimpawu ze-FMS yizi:
- I-Serotonin Reuptake Inhibitors Ekhethiwe (SSRIs)
- I-Serotonin Norepinephrine Reuptake Inhibitors (i-SNRIs)
Yiziphi SSRIs & SNRIs
I-Serotonin ne-norepinephrine yizibili ze-neurotransmitter-amakhemikhali ebuchosheni obuthela imiyalezo evela kwinye i-neuron (ubuchopho beselli) kuya kwenye. Ngamunye usebenza ngemisebenzi eminingi.
Imisebenzi kaSerotonin ihlanganisa ukucubungula ubuhlungu kanye nengxenye evulekile yomjikelezo wokulala. Ubuchopho bakho busebenzisa i-serotonin ukwakha i-melatonin, okusiza ukuthi ulale.
I-Norephinephrin ihileleke ekuphenduleni komzimba, ukuqapha nokukhumbula. Ubuchopho bakho busebenzisa i-norepinephrin ukudala i-neurotransmitter dopamine ephethe ukugxila kwengqondo, ukugqugquzela, kanye nokusebenzisana.
Ukungahambi kahle kwe-serotonin ne-norepinephrin kukholelwa ukuthi kuhlobene namanye amacala we-FMS ne-ME / CFS. I-SSRIs / i-SNRI yenza okuningi kutholakale ngokunciphisa ukuphindwa kabusha, okuyilapho bexhunyiwe ngemuva kokusetshenziswa ukuze bakwazi ukuphinda bavuselelwe. (Thola ulwazi oluthe xaxa: Ukuqonda ukubuyisela kabusha .)
Kwezidakamizwa ezigunyaziwe ze-FDA ze-FMS, amabili kulaba abathathu yi-SNRIs.
(Azikho izidakamizwa ezivunyelwe i-FDA ye-ME / CFS.) Ziyizi:
Amanye ama-SNRIs ayesemakethe futhi angahle anqunywe ngaphandle kwelebula ngenxa yalezi zifo. Zihlanganisa:
- I-Effexor (i-venlafaxine)
- I-Pristiq (desvenlafaxine)
I-SSRI, ebuye ngezinye izikhathi ibhalwe ngaphandle-ilebuli, faka:
- Celexa (citalopram)
- I-Lexapro (i-escitalopram)
- I-Luvox (i-fluvoxamine)
- I-Paxil / Pexeva (i-paroxetine)
- I-Prozac / Sarafem / Selfemra / Rapiflux (i-fluoxetine)
- I-Zoloft (sertraline)
Izingozi: i-Serotonin Syndrome
I-SSRIs, i-SNRIs, neminye imithi ekhulisa i-serotonin ingaholela esimweni esingase sibulale esibizwa nge-serotonin syndrome. Ingozi iyanda uma uthatha izidakamizwa ezingaphezu kweyodwa ze-serotonin, ezingabandakanya imithi yokwelashwa, izidakamizwa zokuzijabulisa kanye nezithako ezithile.
Ukunciphisa ingozi yakho ye-serotonin syndrome, kubalulekile ukuthi utshele udokotela wakho kanye nemithi mayelana nakho konke okuthathayo.
Ungafunda kabanzi mayelana nesifo se-serotonin, kufaka phakathi iziphi izidakamizwa nezithako ezithinta i-serotonin nokuthi yiziphi izimpawu okufanele zibuke, lapha: I-Serotonin Syndrome
Izingozi: ukuzibulala
Ama-SSRIs, ama-SNRIs, nawo wonke amanye ama-anti-depressants anikezwe amandla yi-FDA ukuba athathe isilumkiso se-black-box - isilingo esiqaphile kakhulu - ngesingozi sokuzibulala noma imicabango yokuzibulala kanye nokuziphatha.
Kubalulekile ukuthi noma ubani othatha lezi zidakamizwa azi ukuthi ubungozi, futhi kubalulekile ukuthi abangane namalungu omndeni bakwazi ngakho. Kungenzeka ukuthi yibo ababona izimpawu zokuxwayisa.
Uma uzithola usuphethe imicabango yokuzibulala, thola usizo ngokushesha. Kusukela kuphi e-United States, ungabiza ngo-1-800-273-8255.
Lokho kuyi-hotline ye-VA, kodwa noma ubani wamukelekile ukushayela. Kumele ukhulume nodokotela wakho ngalezi zinkinga nokuthi ngabe kufanele uyeke ukuthatha imithi.
Nazi izinsiza zokuvimbela ukuzibulala:
- Ulwazi lwe-FDA lwaBasebenzi bezeMpilo
- I-Hot Crisis Hotlines (US): 1-800-784-2433 noma 1-800-273-8255
- Izimpawu Zokuxwayisa Ukuzibulala
- Indlela Yokusiza Umuntu Wokuzibulala
Izingozi: Ukuyeka
Ukuhamba kwe-SSRIs / SNRIs kunezingozi zayo siqu. Ukuyeka ngokushesha kungabangela ukuthi yini ebizwa ngokuthi i-discontinuation syndrome, ngakho-ke kufanele ukhulume nodokotela wakho ngezindlela ezifanele zokuzincipha kancane kancane kulo muthi.
Izimpawu ze-discontinu syndrome zifaka:
- Ukukhathala
- Ubuhlungu besisu
- I-nausea
- Ubuhlungu besisu
- Ukungalali
- Ukukhathazeka nokukhathazeka
- Isizungu
- Ama-hallucinations
- Umbono ophundlekile
- Ukuthukuthela
- Ukuzizwa kokulinganisa
- Amaphupho ajwayelekile
- Ukujuluka ngokweqile
- Ukukhathazeka kwamandla kagesi
Izimpawu zokuqeda kungenziwa kusukela ezincane kuya ekudambiseni. Ngenxa yokuthi eziningi zalezo zimpawu nazo zivame ku-FMS naku-ME / CFS, ungabenze iphutha ngezibonakaliso zesifo sakho esiyanda njengoba uncika emithini. Xhumana nodokotela wakho uma unendaba.
Ezinye izinto zingasiza ukunciphisa izimpawu zokuyeka. Ungafunda ngabo kulesi sihloko kusuka kusayithi Lokucindezeleka: Amathiphu Okunciphisa Izimpawu Zokuyeka
Izingozi: Imiphumela Yecala nokusebenzisana
Lezi zidakamizwa zihambisana nohlu olude lwemiphumela emibi. Ezinye zezinto eziyingozi kakhulu zibandakanya ukuthunjwa, ukucubungula kanye nezenzo zangaphandle zokulawula.
I-SSRIs / i-SNRI ingaxhumana kabi nezidakamizwa ngaphandle kwalezo ezandisa i-serotonin. Lezi zingase zihlanganise anti-inflammatories (ama-NSAID), abaxhasi begazi, nabanye abaningi.
Imiphumela emibi kanye nokusebenzisana kuyahlukahluka ngezidakamizwa. Ukuhlola izidakamizwa ezithile, ungabheka ku-Drugs.com noma ku-RxList.com. Zivame futhi zitholakale kulwazi lokupakisha.
Ukunciphisa Ingozi Yakho
Indlela engcono kakhulu yokunciphisa izingozi ezihlobene ne-SSRIs / SNRIs ukulandela ngokucophelela imiyalelo yakho kadokotela kanye nemithi yezokwelapha kokubili umthamo nokulonda. Uma kwenzeka ukuphuthumayo, ungase ufune nokugcina uhlu lwemithi yakho esikhwameni sakho.
Kungasiza ukunyathelisa uhlu lwemiphumela emibi futhi ugcine endaweni ethile ebonakalayo, ikakhulukazi uma uqala imithi emisha. Ngaleyo ndlela, uzokwazi ukubona masinyane ukuthi izimpawu ezintsha ohlangabezana nazo zingase ziboshwe kwisidakamizwa.
Ingabe i-SSRIs / i-SNRIs ikufanele kuwe?
Isinqumo sokuthatha ama-SSRIs noma ama-SNRI senziwa kahle wena nodokotela wakho, ngenkathi ucabangela ukuxilongwa kwakho, izimpawu, impilo yonke, nezindlela zokuphila.
Kungase kudingeke uzame izidakamizwa eziningana kuleli klasi ngaphambi kokuthola okusebenza kahle kuwe nokuthi ungabekezelela. Lokhu kungathatha isikhathi esiningi. Qiniseka ukuthi ugcine imigqa yokuxhumana nodokotela wakho evulekile ngale nqubo.
Imithombo:
U-Arnold LM, et al. Umagazini wezobuchopho wezinhlungu. 2009 Jul-Aug; 25 (6): 461-8. Ukuqhathaniswa kokusebenza nokuphepha kwe-duloxetine yokwelapha i-fibromyalgia kwiziguli ezinokuphikisana ngaphandle kokucindezeleka okukhulu okucindezelekayo.
Choy EH, et al. I-rheumatology yemitholampilo. 2009 Sep; 28 (9): 1035-44. Ukuphepha nokubekezelelana kwe-duloxetine ekwelapheni iziguli ezine-fibromyalgia: ukuhlaziywa okuhlanganisiwe kwedatha kusuka kuvivinyo ezinhlanu zemitholampilo.
Derry S, et al. Idatha yeCochrane yokubuyekeza okuhlelekile. 2012 Mar 14; 3: CD008244. I-Milnacipran ubuhlungu be-neuropathic ne-fibromyalgia kubantu abadala.
I-NIH Publication CHA. 04-5326.
Nishiyori M, et al. Ubuhlungu be-molecular. 2011 Sep 21; 7: 69. Ukukhululeka okuhlala njalo kusuka ekutheni ukucindezeleka okubangelwa ukucindezeleka okubangelwa ukushisa-fibromyalgia-okufana nobuhlungu obungavamile ngokuphathwa ngokuphindaphindiwe kwe-intrathecal kwama-anti-depressants.
I-Saxe PA, et al. Ucwaningo lwamanje lwezokwelapha nemibono. 2012 Mar 19. Isikhathi esifushane (2-Iviki) Imiphumela yokuyeka iMilnacipran kwiziguli ezine-Fibromyalgia.
Ukuphathwa kwe-US nokuDrug. "Ukuphila nge-Fibromyalgia" Kufinyeleleke ngoMashi 2012.
UWarner, uChristopher H, et al. I-American Family Physician. 2006 Aug 1; 74 (3): 449-56. I-Anti-depressant Discontinuation Syndrome.