Ukuqonda i-Fibromyalgia ne-ME / CFS Izidakamizwa
Uma ufunda ngezinketho zokwelashwa kwe- fibromyalgia nesifo esingapheliyo sokukhathala , cishe uthola igama elithi "reubptake inhibitors." Ichaza uhlobo lwe-anti-depressant esivame ukushiwo, kuhlanganise nemithi ye-fibromyalgia evunyelwe yi-FDA Cymbalta (duloxetine) no- Savella (milnacipran) .
Kodwa uqonda ukuthi yini i-reuptake eshoyo?
Uma uqala ukufunda mayelana nama-inhibitors okuphindwa kabusha, kungahle kudideke-siyazi ukuthi lezi zimo zikholelwa ukuthi zibandakanya amazinga aphansi amakhemikhali ebuchopho e-serotonin ne-norepinephrin, ngakho ukuthatha okuthile okukuvimbelayo kuyazwakala okungafani.
Incazelo yalokhu kuhilela isichazamazwi esiyinkimbinkimbi yezokwelapha abaningi bethu abasoze bawaqonda. Ngezansi, uzothola ukuphazamiseka kwalolu hlelo ngolimi olulula ukuluqonda.
Kuyini ukubuyiswa kabusha?
Okokuqala, kancane mayelana nokuthi ubuchopho bakho busebenza kanjani:
Amaseli akho obuchopho (neurons) ahlukaniswa izikhala ezincane. Uma ubuchopho bakho buhambisa imilayezo kusuka kwesinye i-neuron kuya kwesinye, bubopha lezi zikhala ngokukhipha amakhemikhali akhethekile okuthiwa ama-neurotransmitters ukuze athathe umlayezo.
Ngemva kwesikhashana, isikhala esiphakathi kwamaseli ngokuyinhloko sithinteka ngama-neurotransmitter amaningi asetshenzisiwe. Kuyinto efana nokuvula i-imeyili yakho nokuphetha ngezingqimba ze-envelope ezingenalutho-lezi zivilophu zazibalulekile ekukuthumelele i-imeyili, kodwa awusayidingi.
Ubuchopho bakho buhlanza ubuhlungu ngokubuyisela kabusha ama-neurotransmitters ukuze bakwazi ukuvuselelwa kabusha. Ithimba lezokwelapha kulokho liphinda lifakwe kabusha.
Manje ake senze lula futhi senze isinyathelo esengeziwe:
Cabanga ngesicabucabu esikhishwe ngemuva kwesitulo sokudlela. Ufuna ukufika etafuleni, ngakho-ke ususa i-web strand ngaphesheya kwegebe.
Akufanele abe nenkinga eya lapho eya khona, kodwa u-fan oscillating egumbini ulokhu ejika leyo nsizwa futhi ephululela iwebhu ngaphambi kokuba isi-spider sigcwalise uhambo.
Manje, ake ucabange ukuthi othile uguqulela ijubane kumshayeli ukuze aqhube kancane kancane. Lokho kunikeza isikhunta isikhathi esanele sokuwela igebe ngaphambi kokuba iwebhu ibhujiswe.
I-spider isigijimi, iwebhu iyinhlangano ye-neurotransmitter, futhi umshayeli uyaphinda aphinde abuyele. Uma uphinde uqale kabusha, umlayezo unomphetho we-neurotransmitter okwanele ukuthola ukuthi uya kuphi. I-inhibitors yokuphinda i-reuptake ayikhulise inani le-neurotransmitter ebuchosheni bakho, kodwa yandisa isikhathi esitholakalayo. Lokho kusiza imiyalezo ukuthola lapho ihamba khona.
Ukuthi i-Reuptake isebenza kanjani kithi
Abacwaningi bacabanga ukuthi ubuchopho babantu abane-fibromyalgia, isifo esingapheliyo ukukhathala, nezinye izifo eziningi zezinzwa zinezibalo eziphansi zama-neurotransmitter ezithile noma abasebenzisi kahle ama-neurotransmitters. Lokho kubizwa ngokuthi i-neurotransmitter dysregulation, futhi kukholelwa ukuthi yiyona eyabangela izimpawu eziningi zethu, kufaka phakathi ubuchopho bubuchopho nokukhulisa ubuhlungu .
Ukucwaninga kubonisa ukuthi ukunciphisa i-reuptake kusiza ukunciphisa izimpawu eziningana zabantu abaningi abanezifo.
Ama-inhibitors asebekhulile aselekhulile agxilise inqubo yawo wonke ama-neurotransmitters, okwaholela emiphumeleni eminingi engadingeki. I-reuptake yesimiso se-inhibitors yanamuhla ikhetha izinqubo ezithile ze-neurotransmitters-ikakhulukazi i-serotonin ne-norepinephrin. Babizwa ngokuthi:
- I-serotonin reuptake inhibitors ekhethiwe (SSRIs)
- I-Serotonin-norepinephrine reuptake inhibitors (i-SNRIs)
Nakuba lezi zidakamizwa zibangela izinkinga ezimbalwa kunemithi endala, zisenalo uhlu olude lwemiphumela emibi. Ingxenye yenkinga yukuthi asinayo i-neurotransmitter ukuphuleka kuzo zonke izindawo zobuchopho, ngakho-ke imithi ingathuthukisa ukudluliselwa endaweni eyodwa ngenkathi iphazamisa kwenye.
Kodwa-ke, uhlobo olusha lwe-SSRI lukhuphuka olungahlinzeka ngokukhululeka ngemiphumela emibi ngokubhekisisa iseli lobuchopho elithola umyalezo we-neurotransmitter. Lelo seli libizwa ngokuthi i-receptor, futhi i-receptor ngayinye iklanyelwe ukwamukela kuphela imilayezo ethunyelwe yizinzwa ezithile ze-neurotransmitter. Empeleni, i-receptor iyisikhiye. Kuphela okhiye bamakhemikhali abafanele ukuwavula.
Lesi sidakamizwa esisha sisebenzisa izinkomba zamakhemikhali ezifanelwe ukukhohlisa izinsiza ezithile ze-serotonin ekuvulekeni, okwenza kube lula ukuthi imiyalezo igeleza ukusuka kuseli kuya esitokisini. Okungenani umuthi owodwa walolu hlobo-i-Viibryd (i-vilazodone) -yamukelwa manje ukucindezeleka e-United States. (Nokho, akuzange kucwaningwe nganoma iyiphi i-fibromyalgia noma isifo esingapheliyo sokukhathala.)
Funda kabanzi mayelana nokuthi lezi zidakamizwa zisebenza kanjani izimo zethu:
Ukuze ubone izimpawu ezihlobene nokuntuleka kwe-neurotransmitter, kanye nezinketho zokwelashwa, funda:
Imithombo:
Fields, R. Douglas, Ph.D. (2009) I-Other Brain. I-New York: USimon & Schuster.
Goldstein, J. Alasbimn Journal2 (7): April 2000. AJ07-5. "I-Pathophysiology and Treatment of Chronic Chronic Fatigue Syndrome kanye Nezinye Izifo Ze-Neurosomatic Disorders: Ukwelashwa Kokuqonda KuPhilisi."
Smith AK, et al. I-Psychoneuroendocrinology. 2008 Feb; 33 (2): 188-97. Ukuhlolwa kwe-Genetic kwesistimu ye-serotonergic e-syndrome engapheliyo yokukhathala. "
2008 Isikhungo sezokwelapha sase-University of Maryland. Wonke Amalungelo Agodliwe. "Isifo Sokuphela Kwesifo"