Option Treatment for Fibromyalgia
NgoJanuwari 14, 2009, i-FDA yamukela Savella (i-milnacipran HCl) yokuphathwa kwe- fibromyalgia . I-Savella ihlukaniswa njenge-serotonin ekhethiwe futhi i-norepinephrine inhibithali ye-reuptake kabili. Isidakamizwa sisetshenziswe iminyaka eminingana eYurophu nase-Asia ukuphatha ukucindezeleka.
Iyini i-Serotonin ekhethiwe ne-Norepinephrine Dual Reuptake Inhibitor?
Njenge-serotonin ekhethiwe kanye ne-norepinephrin in-reuptake inhibitor, eyaziwa nangokuthi i-SSNRI, i-Savella ikwandisa i-norepinephrine nomsebenzi we-serotonin ebuchosheni.
Emgodini wokuhlola, i-Savella ibonakala inomthelela omkhulu kumsebenzi we-norepinephrine. Lokhu kubalulekile ezigulini ze-fibromyalgia ngoba izilinganiso eziphansi ze-brain norepinephrin zicatshangelwa ukuthi zihlobene nobuhlungu obuningi nokukhula kwengqondo ("ubuchopho buchopho").
I-Savella ihlinzekwa kanjani?
I-Savella ilawulwa ngezidakamizwa ezimbili ezihlukanisiwe ngosuku. Izinga liye landa kancane kancane phakathi neviki lokuqala ukuze uthole umthamo ophakanyisiwe we-100 mg / ngosuku.
I-Savella iyatholakala njenge-12.5 mg, 25 mg, 50 mg, namaphilisi angu-100 mg. Ngosuku lokuqala, uthatha u-12.5 mg kanye. Ezinsukwini ezimbili kuya kwezingu-3, uthatha u-12.5 mg / kabili nsuku zonke. Ezinsukwini ezine kuya ku-7, uthatha u-25 mg / kabili nsuku zonke. Ngemuva kwezinsuku ezingu-7, umthamo ovamile u-50 mg / kabili nsuku zonke. Ezinye iziguli zingadinga 200 mg / ngosuku - kanti ezinye zingadinga umthamo ophansi uma zinezinkinga zokukhubazeka (izinso).
I-Savella Yenziwe Kanjani Emilenzeni Yomtholampilo?
Ukuphepha nokusebenza kuka-Savella kunqunywe emiphumeleni yokuhlolwa kwamagciwane amabili kwesigaba III e-US Kwakukhona iziguli ezingaphezu kuka-2 000 ezine-fibromyalgia ezithintekayo kulezi zifundo.
Ukungafani kwe-Savella
I-Savella inqatshelwe (akufanele isetshenziswe) kuziguli ezine-glaucoma encane engalawuleki. I-Savella akufanele futhi isetshenziswe iziguli ezithatha i-MAOIs (i-monoamine oxidase inhibitors), evame ukusetshenziswa ukucindezeleka. I-Savella ayivunyelwe ukusetshenziswa ezinganeni.
Izixwayiso Ezihlobene No-Savella
Iziguli ezinqunyelwe u-Savella kufanele ziqaphele lezi zixwayiso nezixwayiso ezilandelayo:
- Ukwehlisa izimpawu zokucindezeleka nokubeka ingozi yokuzibulala kungenzeka nge-Savella
- I-Serotonin syndrome (ukusabela kwezidakamizwa ezisongela ukuphila okubangela ukuba umzimba ube ne-serotonin kakhulu) kungenzeka.
- Ukuphakama kwengcindezi yegazi nokushaya kwenhliziyo kungenzeka nge-Savella.
- Ukuzizwa kuye kwabikwa ezigulini ezithatha i-Savella.
- I-hepatotoxicity ibike (iziguli ezinokuphuza utshwala ngokweqile noma isifo esingenasifo esibindile kufanele zigweme i-Savella).
- Izimpawu zokukhipha zingase zenzeke uma i-Savella ingayeki kancane kancane.
- I-Savella ingakhuphula ingozi yokugaya ikakhulukazi ezigulini ezithatha ama-NSAID , i- aspirin , noma ezinye izidakamizwa ezithinta ukuphuma kwegazi.
- Kungase kube namanani aphakeme ezenzakalweni ezimbi ze-genitourinary nokusetshenziswa kwe-Savella.
U-Savella ukhethwe njenge-agent ye-Pregnancy Category C, okusho ukuthi izingozi ze-fetal ezitholakala ezifundweni zesilwane. Umkhiqizi wase-Savella uthi akukho ukuhlolwa okwanele noma okulawulwe kahle okubikiwe kwabesifazane abakhulelwe, ngakho-ke kumele kusetshenziswe ngesikhathi sokukhulelwa kuphela uma izinzuzo ezingase zikwazi ukufakazela izingozi ezingase zibe khona kumntwana.
Ucwaningo olulawulwayo lwe-Savella alukwenziwe kumama abahlengikazi.
Imiphumela Ejwayelekile Yomphakathi kanye Nemicimbi Ebizayo
I-nausea, ikhanda, ukuqothulwa, isizungu, ukuleleka, ukuhlanza, ukujula okukhulu, ukuhlanza, ukuphuza, nomlomo omile kuyisenzo esibi esihlobene no-Savella.
Imithombo:
Ulwazi lwe-Savella Prescribing. Savella.com. 01/08/2009.
http://www.allergan.com/assets/pdf/savella_pi
I-Milnacipran (Savella), i-Treatment Option ye-Fibromyalgia. I-P & T (Pharmacy & Therapeutics) P T. 2010 Meyi; 35 (5): 261-266.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873711/