Ama-neutrophils amhlophe amaseli egazi abalulekile ekulwa nokutheleleka. I-ANC imele inani le-neutrophil eliphelele, futhi ukubalwa kwe-neutrophil kungase kube ngaphansi kwavamile ngenxa yezizathu eziningi, kuhlanganise kokubili izifo kanye nokwelashwa. Ukuwa kwe-ANC kungahle kwenzeke ngenxa yomdlavuza we-chemotherapy, isibonelo.
Umuntu onempilo une-ANC phakathi kuka-2 500 no-6,000.
Ukubalwa kwakho kwe-neutrophil ngokuphelele kungabalwa ngokusebenzisa ukuhlolwa kwegazi okuvamile okubizwa ngokuthi inani eliphelele legazi, noma i-CBC. I-CBC inikeza udokotela wakho wonke amanani akho amangqamuzana egazi abomvu, amangqamuzana amhlophe egazi (ama-WBCs) namaplatelet - izinto ezincane zamaselula ezisiza ukulawula ukuphuma kwegazi. I-ANC itholakala ngokuphindaphinda inani eliphelele lamangqamuzana egazi ngamaphesenti angama-neutrophils.
Isibonelo sokubalwa:
Uma inani lakho le-WBC elingu-8,000 leukocyte namaphesenti angu-50 ama-WBC angama-neutrophils, i-ANC yakho i-neutrophils engama-4,000, ngoba u-8,000 × 0.50 = 4,000.
Ngokuvamile, i-ANC izobalwa ngokuzenzakalelayo njengengxenye yombiko webhu. Uma kungenjalo, ungase ube nezimo lapho i-neutrophils ibikwa khona ngamabhakede amabili ahlukene: "amaqembu" kanye "nezigxobo." Lezi zinganezela ndawonye, futhi kungaba kuhle ukufaka ndawonye inani lamathole nabantu abadala ukuze uthole izinhloko zezinkomo - okungukuthi, "ama-bands" yiyona ndlela engapheliyo ye-neutrophils noma izingodo.
Okuningi ku-ANC
Kungenzeka ukuthi inani lakho le-WBC liphelele kodwa inani lakho le-neutrophil liphansi. Kodwa-ke, njengoba i-neutrophils ivame ukuba nengxenye enkulu kunazo zonke, ngokwemigqa yamhlophe yegazi eliphelele, inani le-WBC livame futhi liphansi uma inani le-neutrophil liphansi.
I-neutrophils yi-WBCs eningi egazini labantu abanempilo futhi ebalulekile ekulwa nokutheleleka.
Empeleni yi-WBC ebaluleke kakhulu ekulwa nokutheleleka. Zivame ukwenza amaphesenti angaba ngu-50 ama-WBC wakho wonke uma uphilile. Ukuba khona kwezinombolo ezincane ze-neutrophils egazini elijikelezayo kuthiwa i- neutropenia . Kunamazinga ahlukene we-neutropenia, kuye ngokuthi i-ANC yakho ihamba kangakanani.
Ngokusho kwe-American Cancer Society, umuntu onempilo une-ANC phakathi kuka-2 500 no-6 000. Uma i-ANC yehla ngaphansi kwe-1 000, kungase kube nengozi enkulu yokutheleleka, ngakho-ke udokotela wakho uzogcina amehlo akho ngokubheka kakhulu; unengozi enkulu yokutheleleka lapho i-ANC ingaphansi kuka-500 .
Ngokuvamile umnkantsha wenza amangqamuzana egazi lakho , kuhlanganise neutrophils. Imithi yokwelapha yomdlavuza yokuphila okubandakanya i-chemotherapy kanye nemisebe ingase ihlose amaseli akhula ngokushesha futhi ithinte kabi ukukhiqizwa kwe-neutrophils - ngakho-ke ukwehla kwe-ANC ngezinye izikhathi kuyilindelekile. Kwezinye izimo, lapho i-ANC ilindeleke ukuba ihle, noma uma isivele iphansi, imithi elwa namagciwane kanye / noma izici zokukhula - imithi esiza ekukhuliseni ukukhiqizwa kwe-neutrophil yakho - ingahle isetshenziswe.
Izimpawu Nezibonakaliso Zokutheleleka
Ukuba nesibalo esincane semhlophe segazi noma ngisho nokubalwa okuphansi kwe-neutrophil akukhiqizi izimpawu ezibonakalayo.
Yingakho kubaluleke kangaka ukuba uqaphele ukuthi kungenzeka ukuthi izimpawu zokutheleleka kungenzeka uma ama-neutrophils akho esephelile. Ngeshwa, njengoba i-ANC iyancipha, eziningi zalezi zibonakaliso zingase zingabonakali uma kutholakala isifo.
Nazi ezinye zezibonakaliso nezimpawu zokutheleleka ukuthi ungaqaphela:
- Fever
- Ama-Chills
- Isikhukhula
- Ukuphefumula okunenkinga
- Uhudo
- Ubuhlungu
Uma kukhona idivaysi yokufinyelela enezinambuzane eziphakathi (umugqa ophakathi noma ichweba), hlola ukubomvu, ukuvuvukala, ubuhlungu noma ukuqhuma esiteshini, lapho ithubhu ingena khona emzimbeni. Umuntu onenkampani ye-ANC ephansi angeke abe nokubomvu noma i-pus, kodwa angase abe nokutheleleka.
Uma i-ANC yakho ihlaselwa ku-1 000 noma iphansi futhi unomkhuhlane, odokotela abaningi bathatha ukukhwabanisa kokholo ukuthi kukhona ukutheleleka, futhi ukwelashwa kwama-antibiotic kuvame ukuqala ngokushesha, ngokuvamile ngaphambi kokuba umthombo wokutheleleka uvezwe.
Bese kuba inqubo yokunciphisa labo abasolwa phakathi kwezifo eziphilayo ezithathelwanayo ngenkathi beqhubeka nokuphatha ngezinqubo zokwelapha ezibandakanya kakhulu. Njengoba izinkomba ezithile zivela, odokotela bangakwazi ukuthola indawo ngqo kanye nezimbangela zokutheleleka nokuthi yiziphi izifo eziphilayo ezingabandakanyeka. Ngale ndlela, bangakhetha ukwelashwa okungenzeka ukuthi basebenze - futhi lokhu kungase kusho ukuthi imishanguzo eyanikezwa okokuqala izoshintshwa komunye owenziwe ngokwengeziwe ngenxa yezigciwane ezibuhlungu.
Izwi elivela
Ukucindezeleka kwama-WBCs, kuhlanganise ikakhulukazi ama-neutrophils, kuyingozi yezokwelapha eziningi zokulwa nomdlavuza. I-ANC ephansi ingabuye ibe isibonakaliso noma isibonakaliso sesifo esiyisisekelo, njengoba kunjalo kwezinye izinhlobo zemdlavuza wegazi.
Ukwengeza, i-ANC ephansi ingase isenze ekwelapheni ezinye izifo ezingapheli, ezifana nezifo zokuzivikela ngokuzivikela njenge-rheumatoid arthritis. Isibonelo, enye yezokwelapha nge-arthritis ye-rheumatoid, tocilizumab, ivimbela isignali yeseli eyaziwa njenge-IL-6 futhi ixhunywe nama-ANC aphansi, nakuba iyancipha ekubalweni kwe-neutrophil kuziguli ezithatha i -cilizumab azibonakali zihlotshaniswa nezifo ezimbi futhi iqondiswe izinyathelo ezithathwe ukunciphisa ingozi yokutheleleka.
Okokugcina, kunqabile kakhulu, kungenzeka ukuthi abantu bangabi nalokhu okuthiwa i-neutropenia eyimvelo engapheli. Lesi sifo asiqondakali kahle, kodwa sinomthelela wesifazane, futhi kubonakala sengathi naphezu kwe-ANC ephansi, izifo ezinzima azivamile, futhi iziguli zinomphumela omuhle kakhulu.
> Imithombo:
> I-American Cancer Society. Ukuqonda Imiphumela Yakho Lab.
> Ama-Moots RJ, Sebba A, uRigby W, et al. Umphumela we-tocilizumab kwi-neutrophils kwiziguli ezikhulile ezine-arthritis ye-rheumatoid: ukuhlaziywa okuhlanganisiwe kwedatha kusuka kwesigaba sesi-3 no-4 ukuhlolwa kwemitholampilo. I-Rheumatology (i-Oxford, eNgilandi) . 2017; 56 (4): 541-549.
> INational Comprehensive Cancer Network (NCCN). Izimo zokukhula zeMyeloid.