I-Angioimmunoblastic T-cell lymphoma (AITL) uhlobo olungavamile lwe-non-Hodgkin lymphoma (NHL ) . Ivela ku- T-amangqamuzana , okuyinto uhlobo lweseli elimhlophe legazi elibhekele ukuvikela umzimba kusuka ezifweni. Kungase kube okufingqiwe i-ATCL futhi ngaphambili yayibizwa nge-angioimmunoblastic lymphadenopathy.
Kuyini Okushiwo I-Angioimmunoblastic?
Igama elithi 'angio' libhekisela emithanjeni yegazi.
Le lymphoma inezici ezithile ezingavamile ezihlanganisa ukwanda kwenani lemithambo engavamile yegazi ezingxenyeni zomzimba ezithintekayo. 'I-Immunoblast' yigama elisetshenziselwa isilonda esincane esingamasosha omzimba (noma i-lymph cell). Amaseli avame ukuvuthwa ngama-lymphocyte, kepha inamba ethile ehlala emnothweni we-bone, ukulungele ukwanda uma kudingeka ezinye i-lymphocytes. Uma kunalokho bakhula ngendlela yabo engafanga futhi abavuthiwe, banomdlavuza. I-T-cells engumdlavuza e-AITL yi-immunoblasts.
Ubani Ongathinta?
I-Angioimmunoblastic T-cell lymphoma yenza kuphela u-1% wabo bonke abangenalo i-Hodgkin lymphoma. Lithinta abantu asebekhulile, abaneminyaka yobudala lapho behlushwa khona eminyakeni engaba ngu-60. Kuyinto evamile kakhulu emadodeni kunabesifazane.
Izimpawu
Ku-AITL, kunezibonakaliso ezivamile zelmphoma ezibandakanya ukwandiswa kwama-lymph nodes (ngokuvamile ezwa entanyeni, emagqumeni, nase-groin), kanye nomkhuhlane, ukulahlekelwa isisindo noma ukujula ebusuku.
Ngaphezu kwalokho, i-angioimmunoblastic T-cell lymphoma inezimpawu eziningi ezingavamile. Lezi zihlanganisa ukuhlukunyezwa kwesikhumba, ubuhlungu obuhlangene, kanye nokunye okungavamile kwegazi. Lezi zimpawu zihlobene nalokho okubizwa ngokuthi i-immune reaction in the body, ihlukaniswe ngamaprotheni angavamile akhiqizwa amangqamuzana omdlavuza.Konke ukutheleleka kubonakala ngoba lesi sifo sibuthakathaka amasosha omzimba.
Le-lymphoma nayo inenkinga enonya kakhulu kunezinye eziningi ze-non-Hodgkin's lymphomas. Ukubandakanya kwesibindi, ubhedu, kanye nomnyobo wethambo kuvame kakhulu. Izimpawu ze-B nazo zibonakala njalo. Lezi zici, ngeshwa, zingase zisho umphumela ompofu ngemuva kokwelashwa.
Ukuxilongwa nokuvivinya
Njengamanye ama-lymphomas, ukuxilongwa kwe-AITL kusekelwe ku- lymph node biopsy . Ukulandela ukuxilongwa, kudingeka ukuhlolwa okuningi ukuze ubone ukuthi i-lymphoma isakaze kangakanani. Lokhu kufaka phakathi ukuhlolwa kwe-CT noma ukuhlolwa kwe- PET , ukuhlolwa komnyofu wamathambo kanye nokuhlolwa kwegazi okwengeziwe.
Uma kunezinsalela zesikhumba, i-biopsy ingathathwa futhi esikhumbeni ukuthola ezinye izici ezibonakalayo ezisiza ukukhomba lesi sifo.
Ukwelapha
Ukwelashwa kokuqala kule lymphoma ngokuvamile kuqondiswa izimpawu zokuzivikela-ukuqhuma, ubuhlungu obuhlangene, kanye nokungafani kwegazi. I-Steroids nezinye izithunywa eziningana zitholakale ziwusizo ekunciphiseni lezi zimpawu.
Uma ukuxilongwa kuqinisekisiwe futhi uphenyo lwesiteleka luqediwe, i-chemotherapy iqalile. I-CHOP iyimithi ejwayelekile kakhulu ye-chemotherapy esetshenzisiwe. Kodwa-ke, isifo sibuyele futhi singenzeka ezinyangeni zokulawula isifo sokuqala. Ukwelashwa okuqhubekayo kwalolu lymphoma kunzima.
Kunezinyathelo eziningana eziye zavivinywa, kuhlanganise nomnkantsha wamathambo noma ukuguqulwa kwe-stem cell. Izifo zezinkinga ziye zaqhubeka zibi kakhulu kunezinhlobo ezivame kakhulu ze-high-grade lymphoma.
Imithombo:
I-Cancer: Izimiso Nokusebenza Kwe-Oncology 7th Edition. Abahleli: VT DeVita, S Hellman noSA Rosenberg. Ishicilelwe nguLippincott Williams noWilkins, ngo-2005.
Ukwelashwa Kwama-T / NK Neoplasms E-Peripheral. Umbhali JP Greer. Ishicilelwe encwadini ye-Hematology ngo-2006.
I-Adult Non-Hodgkin Treatment Lymphoma-yezokwelapha (PDQ®) National Cancer Institute. Ibuyekezwe ngoJanuwari 15, 2016.