I-CHOP yigama elifingqiwe ngenhlanganisela yemithi ehlukene. I-CHOP ingenye yezinhlanganisela ezivame kakhulu zemithi esetshenziselwa i- non-Hodgkin lymphoma, noma i-NHL . I-CHOP isetshenziselwa izinhlobo ezithile ezivame ukuhlukumezeka kanye ne-NHL indolent . Iqukethe imithi emine ehlukene: i-cyclophosphamide (i-Cytoxan), i-doxorubicin (i-Adriamycin), i-vincristine (i-Oncovin) ne-prednisone.
I-CHOP ivame ukuhlanganiswa ne-rituximab emthethweni we- R-CHOP .
Izidakamizwa zokuqala ezintathu ze-CHOP chemotherapy regimen zivame ukunikezwa njengezijova noma izifo zemithanjeni ngosuku olulodwa, kanti i-prednisone ithathwa njengepilisi izinsuku ezinhlanu. Ngokuvamile, irejista eyaziwa ngokuthi i-R-CHOP inikezwa ngemijikelezo amaviki amathathu ngaphandle kwamasonto ama-6-8.
Izidakamizwa zinikezwa ukulwa kwe-CHOP ngamaseli omdlavuza ngezindlela ezahlukene. Lapho i-cyclophosphamide isetshenziselwa ukwelapha i-chemotherapy e-CHOP, isebenza ngokunciphisa noma ukuvimbela ukukhula kwamangqamuzana omdlavuza emzimbeni wakho. Kungaba nokulimala okunye kokubambisana ngoba kuthinta futhi ukwehlukanisa ngokushesha amangqamuzana emzimbeni onempilo, njengalezo ezikhiqiza izinwele kanye nalabo abasendlini ye-gut-kanjalo ukulahlekelwa izinwele kanye nezimpawu zamathumbu kungenzeka imiphumela emibi.
U-Doxorubicin useklasini lemithi ebizwa ngokuthi i-anthracyclines, futhi isebenza ngokunciphisa noma ukuvimbela ukukhula kwamangqamuzana omdlavuza.
UVincristine usebenza ukuvimbela umdlavuza wamangqamuzana ukuba awuphindaphindiwe, ngokuyingxenye ngokuhlaselwa kwe-tubyssing of tubes ukuthi amangqamuzana eseli asetshenziselwe ukuhlukanisa nokuhlukanisa. Amaseli e-Cancer aphethwe yi-chemotherapy kunama cell ajwayelekile, kodwa i-chemotherapy nayo inomthelela emangqamuzaneni ajwayelekile, okwenza kube khona amaphrofayili omphumela ocacile.
Ama-Lymphomas Aphathwa Ngesi-CHOP + Rituximab
I-Cyclophosphamide, i-doxorubicin, i-vincristine, ne-prednisone (CHOP), yilokhu okuyisigqila sokwelapha amashumi ambalwa eminyaka ngeziguli ezine-B-cell lymphoma enkulu (DLBCL) ehlukumeza kakhulu. Iningi leziguli ezine-DLBCL zingelashwa nge-standard rituximab + cyclophosphamide, doxorubicin, vincristine, ne-prednisone (R-CHOP), noma kunjalo, imiphumela ayihambisani nalabo abangenzi kahle kulolu hlobo.
I-CHOP chemotherapy isetshenziselwa izinhlobo eziningi ezivamile ze-non-Hodgkin lymphomas, okubandakanya i-angioimmunoblastic T-cell Lymphoma, kanye ne-T-cell lymphoma ye-peripheral. I-R-CHOP protocol isibe yindinganiso yokwelashwa kobudlova, I-Stage I ne-Contiguous Stage II Adult Adult NHL kanye ne-NHL yabantu abahlukumezayo, abangenakuqhathaniswa nesiteleka se-Stage II / III / IV.
Ukuphatha nokuqapha
I-Adriamycin ivame ukunikezwa kuqala ngoba ingayicasula imithwalo yegazi. Kubalulekile ukuthi utshele umhlengikazi we-infusion uma uzizwa uvutha noma ubuhlungu kusayithi lokungenisa . Ngosuku olufanayo, uzophinde unikezwe izidakamizwa ezimbili ezilandelayo, i-Cytoxan ne-Vincristine.
Umtholampilo uzotusa ukuba umshayeli akuyise ekhaya ngemuva kokwelashwa ngalunye. Ungabona ushintsho embala womchamo wakho kusuka kumbala obomvu we-Adriamycin izinsuku ezimbalwa ngemva kokwelashwa.
Imiphumela Ejwayelekile Ejwayelekile
- Ukulahlekelwa izinwele: Uzoba nokulahlekelwa izinwele ngokuphelele, kufaka phakathi izinwele ekhanda lakho kanye namashiya, i-eyelashes, nezinwele zomzimba. Ngokuvamile, lokhu kuqala amasonto amabili kuya kwamathathu ngemuva kokwelashwa, kodwa kungokwesikhashana futhi izinwele zakho kufanele zibuyele ngemuva kokwelashwa.
- I-nausea nokuhlanza kuvamile, kusukela ngokushesha ngemva kokwelapha ezinsukwini ezintathu emva kokwelashwa.
- Ukuqothulwa kuvamile ngoba i-vincristine kanye neminye imithi ivame ukuhlinzekwa nge-nausea nobuhlungu.
- Izilonda zomlomo zingase zivele ngesonto ukuya emavikini amabili ngemuva kokwelashwa.
- Izinkinga zokuzala: Abesifazane bavame ukuphazanyiswa kwemijikelezo yabo yokuya esikhathini futhi bangase bangene ngokuya esikhathini sokuhlala. Amadoda angayeka ukukhiqiza isidoda, ukunciphisa ukuzala. Lezi zimo zingase zibe unomphela, ngakho kufanele uxoxe ngokukhetha ukwelashwa nodokotela wakho ngaphambi kokuqala ukwelashwa. Ngakolunye uhlangothi, ungacabangi ukuthi uzobe ungenasifo ngenkathi ukwelashwa, sebenzisa ukuvimbela ukuvimbela ukukhulelwa.
- Ungase ulungele ukutheleleka ngesikhathi ukwelashwa kwe-CHOP njengoba kuzokwehlisa okwesikhashana amaseli akho amhlophe egazi namaseli abomvu, okwehlisa isimiso sakho somzimba omzimba. Kuwukuhlakanipha ukugwema ukuthintana nabantu abashisayo noma umkhuhlane kanye nokugeza izandla njalo ukuvimbela ukuthola igciwane noma ukutheleleka.
- I-Prednisone iyi-steroid futhi inemiphumela emibi eminingi engaba khona, kufaka phakathi ukushintsha kwemizwa, ukuzuza kwesisindo, nokuvuvukala.
> Imithombo:
> Sehn LH, Gascoyne RD. Ukusakaza i-B-cell lymphoma enkulu: ukwandisa umphumela kumongo we-heterogeneity yomtholampilo kanye ne-biologic. Igazi. 2015; 125 (1): 22-32.
> Imiphumela engase ibe khona yeCyclophosphamide, i-Doxorubicin, i-Vincristine, ne-Prednisone (CHOP), iNational Cancer Institute, ngoNovemba 27, 2013.
> I-Adult Non-Hodgkin Lymphoma Treatment-yezokwelapha (PDQ®), National Cancer Institute, ngoJanuwari 15, 2016.